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Nhlh2 Gene Detail
Summary
  • Symbol
    Nhlh2
  • Name
    nescient helix loop helix 2
  • Synonyms
    6230401I09Rik, bHLHa34, Hen2, Nscl-2, NSCL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97324
    NCBI Gene: 18072
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:101917425-101922808 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 44.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    198 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97324
 protein coding gene Chr3:101917392-101922808 (+)
129S1/SvImJ ENSMUSG00200042573
 protein coding gene Chr3:98523120-98528556 (+)
A/J ENSMUSG00195047649
 protein coding gene Chr3:98920893-98926320 (+)
AKR/J ENSMUSG00220034292
 protein coding gene Chr3:97283402-97288838 (+)
BALB/cJ ENSMUSG00180034396
 protein coding gene Chr3:98860522-98865949 (+)
C3H/HeJ ENSMUSG00175022984
 protein coding gene Chr3:98406642-98412066 (+)
C57BL/6NJ ENSMUSG00215015452
 protein coding gene Chr3:99180509-99185928 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025435
 protein coding gene Chr3:96130857-96136197 (+)
CAST/EiJ ENSTCUG00005019316
 protein coding gene Chr3:99138758-99144217 (+)
CBA/J ENSMUSG00210050781
 protein coding gene Chr3:99028749-99034173 (+)
DBA/2J ENSMUSG00185035973
 protein coding gene Chr3:99522959-99528378 (+)
FVB/NJ ENSMUSG00205018140
 protein coding gene Chr3:98100090-98105527 (+)
JF1/MsJ ENSUMUG00000034921
 protein coding gene Chr3:98238942-98244384 (+)
LP/J ENSMUSG00230043495
 protein coding gene Chr3:101451618-101457048 (+)
NOD/ShiLtJ ENSMUSG00190029462
 protein coding gene Chr3:99704272-99709687 (+)
NZO/HlLtJ ENSMUSG00225019905
 protein coding gene Chr3:103902552-103907967 (+)
PWK/PhJ ENSLUMG00010025214
 protein coding gene Chr3:98318160-98323604 (+)
SPRET/EiJ ENSMSPG00010038893
 protein coding gene Chr3:98562039-98565402 (+)
WSB/EiJ ENSIUOG00005028574
 protein coding gene Chr3:99046522-99051940 (+)



Homology
more
  • Human Ortholog
    NHLH2, nescient helix-loop-helix 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NHLH2, nescient helix-loop-helix 2
  • Synonyms
    bHLHa34, HEN2, HH27, NSCL2
  • Links
    NCBI Gene ID: 4808
    UniProt: Q02577

  • Chr Location
    1p13.1; chr1:115831344-115843917 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NHLH2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 5 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Loss of function results in adult-onset obesity and reproductive defects, including hypogonadism, due to disruption of the hypothalamic-pituitary axis. Mutant male mice are sterile, whereas female mice show variable fertility dependent on the presence orabsence of male mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    945
  • Tissues
    203
  • cDNA Data
    26
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18072 NCBI Gene Model | MGI Sequence Detail 5384 C57BL/6J ±  kb
    transcript NM_178777 RefSeq | MGI Sequence Detail 2568 C57BL/6  
    polypeptide Q64221 UniProt | EBI | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 2
      cDNA 29
      Primer pair 3
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12843, MGI:2443536
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 51
      Diseases 1
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:2496 Brown L, et al., HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8492-6
    • Latest
      J:369755 Perry CH, et al., TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions. Genes Dev. 2025 Jul 1;39(13-14):849-867
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory