Tg(Dct-lacZ)#Ove
Transgene Detail

Summary

• Symbol: Tg(Dct-lacZ)#Ove
• Name: transgene insertion, Paul A Overbeek
• MGI ID: MGI:5140350
• Synonyms: Dct^lacZ, TRP2-lacZ
• Transgene: Tg(Dct-lacZ)#Ove Location: unknown
• Alliance: Tg(Dct-lacZ)#Ove page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: A 3.7 kb fragment of the upstream region of the mouse Dct gene drives expression a lacZ gene. Four founders expressing the transgene were generated. All lines show a similar pattern of expression. Transgene expression is detected in early retinal pigment epithelium (RPE), early neural crest cells, optic nerve, and neural crest-derived neuronal cells. This transgene can be used to study melanocyte development. (J:134392)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134392 Zhao S, et al., Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues. Dev Biol. 1999 Dec 1;216(1):154-63
• All: 6 reference(s)