Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1Nrd mutation
(1 available);
any
Ednrb mutation
(103 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
Tg(Tyr-cre/ERT2)13Bos mutation
(12 available)
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pigmentation
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• following TAM treatment immediately after wounding at 8 weeks of age, mice show a significantly reduced number of epidermal melanocytes in the wound area both at day 0 and day 8 after re- epithelialization relative to control mice
• however, no signs of apoptosis are observed, suggesting normal survival of epidermal melanocytes after wounding
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• following initial TAM treatment during 2nd anagen, the number of Dct-LacZ+ melanocyte stem cells (McSCs) in unpigmented hair follicles is significantly lower than that in control mice by the 2nd telogen; most unpigmented hair follicles completely lack McSCs by the 3rd and 4th telogen
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integument
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• following TAM treatment immediately after wounding at 8 weeks of age, mice show a significantly reduced number of epidermal melanocytes in the wound area both at day 0 and day 8 after re- epithelialization relative to control mice
• however, no signs of apoptosis are observed, suggesting normal survival of epidermal melanocytes after wounding
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
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pigmentation
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
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integument
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
Tg(Tyr-cre/ERT2)13Bos mutation
(12 available)
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pigmentation
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
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integument
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
|
|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation
(2 available)
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pigmentation
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N |
• following wounding, mice show no differences in the recruitment of epidermal melanocytes to the wound area relative to control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl27aSfa mutation
(0 available);
any
Rpl27a mutation
(52 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
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pigmentation
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• dramatic increase in epidermal melanocyte numbers with increased deposition of melanin granules in the foot pads and tail
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• dramatic increase in epidermal melanocyte numbers with increased deposition of melanin granules
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• hyperpigmentation of the tail
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integument
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• dramatic increase in epidermal melanocyte numbers with increased deposition of melanin granules in the foot pads and tail
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• hyperpigmentation of the tail
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limbs/digits/tail
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• hyperpigmentation of the tail
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Analysis Tools