Rasgef1b^tm1.1Sila
Targeted Allele Detail

Summary

• Symbol: Rasgef1b^tm1.1Sila
• Name: RasGEF domain family, member 1B; targeted mutation 1.1, Aristobolo Mendes da Silva
• MGI ID: MGI:7859528
• Synonyms: Rasgef1b^flox
• Gene: Rasgef1b Location: Chr5:99365279-99400786 bp, - strand Genetic Position: Chr5, 48.46 cM
• Alliance: Rasgef1b^tm1.1Sila page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 8 via homologous recombination. Flp-mediated recombination removed the neo cassette leaving exons 7 and 8 floxed. (J:342627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasgef1b Mutation: 41 strains or lines available

References

• Original: J:342627 Fernandes HB, et al., Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages. Sci Rep. 2023 Nov 10;13(1):19614
• All: 2 reference(s)