Analysis Tools
behavior/neurological
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• reduced latency to step down in a step-down inhibitory avoidance test at both1.5 h and 24 h after training
• however, Y-maze results indicate no defect in working memory
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• immobility times and frequency of immobility are reduced in a forced swim test compared to controls
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• in a sucrose preference test mice show a reduction in sucrose preference on day three unlike controls that show an increased sucrose preference at this time
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• spend more time in the light side in a light/dark test
• however, no difference in time spent in open arms or number of entries in the open arm in an elevated plus maze
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• spend more time in the center of an open field compared to controls
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• significant improvement in motor performance (longer latency to fall) on the 3rd day of an accelerating rotarod assay compared to wild-type controls that reach a plateau in performance by day 3
• however, no difference in the motor learning index is detected
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• increase in total distance traveled in an open field
• increased number of transitions in a light dark chamber assay and increase in total number of arm entrances in a Y-maze and in an elevated plus-maze
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• in a marble-burying test bury significantly more marbles compared to controls
• treatment with fluoxetine restores marble burying behavior to levels similar to wild-type
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nervous system
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• decrease in total branch length and total sum interactions in the prefrontal cortex
• in the hippocampus but not the prefrontal cortex there is a decreased cell body length to total cell ratio, increased total branch length, and increased total sum interactions
• no alterations in microglia are seen in the striatum
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homeostasis/metabolism
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• decreased TNF concentration in the hippocampus but increased in the prefrontal cortex
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cellular
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• decrease in total branch length and total sum interactions in the prefrontal cortex
• in the hippocampus but not the prefrontal cortex there is a decreased cell body length to total cell ratio, increased total branch length, and increased total sum interactions
• no alterations in microglia are seen in the striatum
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hematopoietic system
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• decrease in total branch length and total sum interactions in the prefrontal cortex
• in the hippocampus but not the prefrontal cortex there is a decreased cell body length to total cell ratio, increased total branch length, and increased total sum interactions
• no alterations in microglia are seen in the striatum
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immune system
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• decrease in total branch length and total sum interactions in the prefrontal cortex
• in the hippocampus but not the prefrontal cortex there is a decreased cell body length to total cell ratio, increased total branch length, and increased total sum interactions
• no alterations in microglia are seen in the striatum
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• decreased TNF concentration in the hippocampus but increased in the prefrontal cortex
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