Albtm1(cre/ERT2)Mtz/Alb+
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6
|
increased cholangiocarcinoma incidence |
J:192740
|
Cpa3tm3(icre)Hrr/Cpa3+
Notch1tm1Agt/Notch1tm1Agt
involves: 129 * C57BL/6
|
abnormal B cell differentiation |
J:143731
|
|
abnormal B cell morphology |
J:143731
|
|
abnormal T cell receptor beta chain V(D)J recombination |
J:143731
|
|
decreased double-negative T cell number |
J:143731
|
|
decreased double-positive T cell number |
J:143731
|
|
increased single-positive T cell number |
J:143731
|
|
thymus hypoplasia |
J:143731
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA
|
decreased B cell number |
J:167000
|
|
enlarged spleen |
J:167000
|
|
increased leukemia incidence |
J:167000
|
|
increased leukocyte cell number |
J:167000
|
|
premature death |
J:167000
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * ICR
|
abnormal endocrine pancreas morphology |
J:86975
|
|
abnormal exocrine pancreas morphology |
J:86975
|
|
abnormal pancreas development |
J:86975
|
|
decreased pancreatic alpha cell number |
J:86975
|
|
decreased pancreatic beta cell number |
J:86975
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA
|
abnormal pancreas development |
J:169830
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)35.10Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA
|
abnormal pancreas development |
J:86975
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/Esr1*)1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA
|
absent pancreatic alpha cells |
J:86975
|
|
embryonic lethality during organogenesis, complete penetrance |
J:86975
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Col1a1-cre)1Kry/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
|
abnormal bone marrow cavity morphology |
J:233131
|
|
abnormal skeleton morphology |
J:233131
|
|
abnormal trabecular bone morphology |
J:233131
|
|
decreased body weight |
J:233131
|
|
decreased bone trabecular spacing |
J:233131
|
|
increased bone mass |
J:233131
|
|
increased bone trabecula number |
J:233131
|
|
increased trabecular bone thickness |
J:233131
|
|
increased trabecular bone volume |
J:233131
|
|
kinked tail |
J:233131
|
|
osteosclerosis |
J:233131
|
|
postnatal growth retardation |
J:233131
|
|
thick neurocranium |
J:233131
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre)C1Able/0
involves: 129S4/SvJaeSor
|
abnormal pancreas development |
J:190530
|
|
abnormal pancreatic duct morphology |
J:190530
|
|
absent pancreatic islets |
J:190530
|
|
decreased body weight |
J:190530
|
|
normal
endocrine/exocrine gland phenotype |
J:190530
|
|
hyperglycemia |
J:190530
|
|
postnatal lethality, complete penetrance |
J:190530
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S4/SvJaeSor * 129S6/SvEvTac
|
normal
vision/eye phenotype |
J:118372
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129S4/SvJaeSor * C57BL/6J
|
abnormal renal tubule morphology |
J:185844
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Hes1tm1(cre/ERT2)Lcm/Hes1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
|
abnormal pancreas development |
J:169830
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
|
abnormal white fat cell differentation |
J:237232
|
|
absent epididymal fat pad |
J:237232
|
|
decreased susceptibility to diet-induced obesity |
J:237232
|
|
hepatic steatosis |
J:237232
|
|
hyperglycemia |
J:237232
|
|
increased circulating insulin level |
J:237232
|
|
increased liposarcoma incidence |
J:237232
|
|
increased liver weight |
J:237232
|
|
insulin resistance |
J:237232
|
|
lipodystrophy |
J:237232
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Wt1-cre)#Jbeb/0
involves: 129S4/SvJaeSor
|
abnormal epicardium morphology |
J:178290
|
|
hemopericardium |
J:178290
|
|
lethality throughout fetal growth and development |
J:178290
|
|
thin myocardium compact layer |
J:178290
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurod1-cre)1Able/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
|
abnormal pancreas morphology |
J:190530
|
|
abnormal pancreatic islet morphology |
J:190530
|
|
normal
homeostasis/metabolism phenotype |
J:190530
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/ERT2)1Able/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
|
normal
endocrine/exocrine gland phenotype |
J:190530
|
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
involves: 129S4/SvJae * C57BL/6
|
no abnormal phenotype detected |
J:86975
|
Notch1sot/Notch1sot
involves: 129S1/Sv * C57BL/6 * FVB/NJ
|
abnormal nervous system development |
J:171522
|
|
abnormal trigeminal ganglion morphology |
J:171522
|
|
abnormal vascular development |
J:171522
|
|
decreased embryo size |
J:171522
|
|
embryonic lethality during organogenesis, complete penetrance |
J:171522
|
|
small pharyngeal arch |
J:171522
|
Notch1tm1.1(cre/ERT2)Sat/Notch1+
C57BL/6-Notch1tm1.1(cre/ERT2)Sat
|
no abnormal phenotype detected |
J:179632
|
Notch1tm1.1(cre/ERT2)Sat/Notch1tm1.1(cre/ERT2)Sat
C57BL/6-Notch1tm1.1(cre/ERT2)Sat
|
embryonic lethality |
J:179632
|
Notch1tm1Agt/Notch1tm1Agt
involves: 129
|
no abnormal phenotype detected |
J:55400
|
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA
|
abnormal B cell differentiation |
J:125373
|
|
abnormal T cell differentiation |
J:55400,
J:125373
|
|
abnormal thymus cell ratio |
J:55400,
J:143472
|
|
abnormal thymus morphology |
J:55400
|
|
decreased body weight |
J:55400
|
|
decreased CD4-positive, alpha-beta T cell number |
J:55400
|
|
decreased CD8-positive, alpha-beta T cell number |
J:55400
|
|
decreased double-negative T cell number |
J:55400
|
|
decreased double-positive T cell number |
J:55400
|
|
decreased single-positive T cell number |
J:55400
|
|
decreased thymocyte number |
J:55400
|
|
normal
hematopoietic system phenotype |
J:98129
|
|
increased immature B cell number |
J:143472
|
|
postnatal growth retardation |
J:55400
|
|
premature death |
J:55400
|
|
small thymus |
J:55400
|
Notch1tm1Agt/Notch1tm1Agt
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL
|
abnormal angiogenesis |
J:100449
|
|
abnormal anterior cardinal vein morphology |
J:100449
|
|
abnormal intersomitic vessel morphology |
J:100449
|
|
abnormal placental labyrinth vasculature morphology |
J:100449
|
|
abnormal somite development |
J:100449
|
|
abnormal vascular branching morphogenesis |
J:100449
|
|
abnormal vitelline vascular remodeling |
J:100449
|
|
delayed heart looping |
J:100449
|
|
embryonic growth arrest |
J:100449
|
|
embryonic growth retardation |
J:100449
|
|
embryonic lethality during organogenesis, complete penetrance |
J:100449
|
|
hemopericardium |
J:100449
|
|
hemorrhage |
J:100449
|
|
incomplete embryo turning |
J:100449
|
|
increased apoptosis |
J:100449
|
|
neural tube degeneration |
J:100449
|
|
pericardial effusion |
J:100449
|
|
thin myocardium |
J:100449
|
Notch1tm1Agt/Notch1tm1Agt
Tg(Tek-cre)12Flv/0
involves: 129 * C3H * C57BL/6
|
abnormal angiogenesis |
J:100449
|
|
abnormal anterior cardinal vein morphology |
J:100449
|
|
abnormal intersomitic vessel morphology |
J:100449
|
|
abnormal placental labyrinth vasculature morphology |
J:100449
|
|
abnormal somite development |
J:100449
|
|
abnormal vascular branching morphogenesis |
J:100449
|
|
abnormal vitelline vascular remodeling |
J:100449
|
|
delayed heart looping |
J:100449
|
|
embryonic growth arrest |
J:100449
|
|
embryonic growth retardation |
J:100449
|
|
embryonic lethality during organogenesis, complete penetrance |
J:100449
|
|
hemopericardium |
J:100449
|
|
hemorrhage |
J:100449
|
|
incomplete embryo turning |
J:100449
|
|
increased apoptosis |
J:100449
|
|
neural tube degeneration |
J:100449
|
|
pericardial effusion |
J:100449
|
|
thin myocardium |
J:100449
|
Notch1tm1Agt/Notch1tm1Agt
Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2
|
diluted coat color |
J:116658
|
Notch1tm1Agt/Notch1tm1Agt
Tg(Wt1-cre)#Jbeb/0
involves: 129
|
abnormal coronary vessel morphology |
J:178290
|
|
absent coronary vessels |
J:178290
|
|
embryonic lethality during organogenesis |
J:178290
|
|
hemopericardium |
J:178290
|
|
hemorrhage |
J:178290
|
|
myocardium hypoplasia |
J:178290
|
|
thin myocardium compact layer |
J:178290
|
Notch1tm1b(EUCOMM)Hmgu/Notch1+
C57BL/6N-Notch1tm1b(EUCOMM)Hmgu/H
|
abnormal vertebrae morphology |
J:211773
|
|
increased grip strength |
J:211773
|
|
increased startle reflex |
J:211773
|
Notch1tm1b(EUCOMM)Hmgu/Notch1tm1b(EUCOMM)Hmgu
C57BL/6N-Notch1tm1b(EUCOMM)Hmgu/H
|
preweaning lethality, complete penetrance |
J:211773
|
Notch1tm1Con/Notch1+
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
aortic valve inflammation |
J:187551
|
|
calcified aortic valve cusp |
J:187551
|
|
normal
cardiovascular system phenotype |
J:187551
|
|
thick aortic valve cusps |
J:187551
|
Notch1tm1Con/Notch1tm1Con
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
abnormal cell death |
J:25248
|
|
abnormal left-right axis symmetry of the somites |
J:25248
|
|
abnormal rostral-caudal axis patterning |
J:25248
|
|
abnormal somite development |
J:25248,
J:62882
|
|
abnormal somite size |
J:25248
|
|
decreased embryo size |
J:25248
|
|
delayed somite formation |
J:25248
|
|
distended pericardium |
J:25248,
J:62882
|
|
embryonic growth arrest |
J:25248,
J:62882
|
|
embryonic lethality during organogenesis, complete penetrance |
J:25248
|
|
kinked neural tube |
J:62882
|
|
notochord degeneration |
J:25248
|
Notch1tm1Con/Notch1tm1Con
involves: 129S1/Sv * 129X1/SvJ
|
abnormal myocardium layer morphology |
J:119151
|
|
disorganized myocardium |
J:119151
|
|
trabecula carnea hypoplasia |
J:119151
|
Notch1tm1Con/Notch1tm1Grid
Tg(Pax2-cre)1Akg/0
involves: 129S1/Sv * 129X1/SvJ
|
abnormal vascular development |
J:119907
|
|
embryonic lethality during organogenesis, complete penetrance |
J:119907
|
|
internal hemorrhage |
J:119907
|
|
normal
renal/urinary system phenotype |
J:119907
|
Notch1tm1Grid/Notch1+
involves: 129S1/Sv * C57BL/6
|
abnormal retina blood vessel morphology |
J:227333
|
|
increased cochlear outer hair cell number |
J:62727
|
Notch1tm1Grid/Notch1tm1Grid
involves: 129S1/Sv * C57BL/6
|
abnormal dorsal aorta morphology |
J:62571
|
|
abnormal placenta vasculature |
J:62571
|
|
absent vitelline blood vessels |
J:62571
|
|
decreased angiogenesis |
J:62571
|
|
embryonic growth retardation |
J:17509
|
|
embryonic lethality during organogenesis, complete penetrance |
J:17509
|
|
pale yolk sac |
J:62571
|
Notch1tm1Grid/Notch1tm2Rko
Foxg1tm1(cre)Skm/Foxg1+
involves: 129 * C57BL/6J * Swiss Webster
|
decreased organ of Corti supporting cell number |
J:132241
|
|
increased cochlear inner hair cell number |
J:132241
|
Notch1tm1Pst/Notch1tm1Pst
involves: 129/Sv * C57BL/6 * SJL
|
abnormal embryonic tissue morphology |
J:112097
|
|
embryonic growth retardation |
J:112097
|
|
embryonic lethality during organogenesis, complete penetrance |
J:112097
|
Notch1tm1Rko/Notch1tm1Rko
involves: 129X1/SvJ
|
abnormal rostral-caudal axis patterning |
J:62882
|
|
abnormal somite development |
J:62882
|
|
absent vitelline blood vessels |
J:62882
|
|
distended pericardium |
J:62882
|
|
embryonic growth arrest |
J:62882
|
|
embryonic growth retardation |
J:62882
|
|
embryonic lethality, complete penetrance |
J:62882
|
|
kinked neural tube |
J:62882
|
Notch1tm2.1Rko/Notch1+
Not Specified
|
abnormal vertebrae morphology |
J:186213
|
Notch1tm2Agt/Notch1tm2Agt
involves: 129
|
abnormal artery morphology |
J:89444
|
|
abnormal cardiac epithelial to mesenchymal transition |
J:133699
|
Notch1tm2Agt/Notch1tm2Agt
involves: 129/Sv * C57BL/6
|
embryonic lethality during organogenesis, complete penetrance |
J:55400
|
Notch1tm2Pst/Notch1tm2.1Pst
B6.Cg-Notch1tm2.1Pst
|
embryonic growth retardation |
J:131563
|
|
embryonic lethality during organogenesis, complete penetrance |
J:131563
|
Notch1tm2Pst/Notch1tm2.1Pst
involves: 129/Sv * C57BL/6 * SJL
|
abnormal embryonic neuroepithelium morphology |
J:131563
|
|
abnormal heart development |
J:131563
|
|
abnormal vasculogenesis |
J:131563
|
|
anemia |
J:131563
|
|
decreased embryo size |
J:131563
|
|
embryonic growth retardation |
J:131563
|
|
embryonic lethality during organogenesis, complete penetrance |
J:131563
|
Notch1tm2Pst/Notch1tm2Pst
B6.Cg-Notch1tm2Pst
|
abnormal T cell differentiation |
J:131563
|
|
decreased double-negative T cell number |
J:131563
|
|
decreased T cell number |
J:131563
|
|
decreased thymocyte number |
J:131563
|
|
increased T cell apoptosis |
J:131563
|
|
postnatal growth retardation |
J:131563
|
Notch1tm2Rko/Notch1tm2Rko
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129X1/SvJ * C57BL/6 * CBA
|
normal
craniofacial phenotype |
J:181120
|
|
perinatal lethality, complete penetrance |
J:181120
|
Notch1tm2Rko/Notch1tm2Rko
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N
|
alopecia |
J:194073
|
|
decreased conjunctiva goblet cell number |
J:194073
|
|
dry eyes |
J:194073
|
|
lacrimal gland degeneration |
J:194073
|
|
Meibomian gland degeneration |
J:194073
|
Notch1tm2Rko/Notch1tm2Rko
Tg(Msx2-cre)5Rem/0
Not Specified
|
abnormal hair follicle morphology |
J:94517
|
|
abnormal hair growth |
J:94517
|
|
abnormal hair shaft morphology |
J:94517
|
|
disorganized inner root sheath cells |
J:94517
|
|
short hair |
J:94517
|
|
small sebaceous gland |
J:94517
|
|
waved hair |
J:94517
|
Notch1tm2Rko/Notch1tm2Rko
Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6J * SJL
|
abnormal apoptosis |
J:90392
|
|
increased neuron number |
J:90392
|
Notch1tm2Rko/Notch1tm3(cre)Rko
involves: 129X1/SvJ * C57BL/6
|
abnormal cornea morphology |
J:171829
|
|
abnormal hepatic cord morphology |
J:171829
|
|
abnormal liver lobule morphology |
J:171829
|
|
abnormal liver morphology |
J:171829
|
|
abnormal liver parenchyma morphology |
J:171829
|
|
abnormal spleen morphology |
J:171829
|
|
chronic liver inflammation |
J:171829
|
|
cornea deposits |
J:171829
|
|
cornea vascularization |
J:171829
|
|
dilated liver sinusoidal space |
J:171829
|
|
enlarged spleen |
J:171829
|
|
extramedullary hematopoiesis |
J:171829
|
|
hemoperitoneum |
J:171829
|
|
increased angiogenesis |
J:171829
|
|
increased hemangioma incidence |
J:171829
|
|
pale liver |
J:171829
|
|
premature death |
J:171829
|
Notch1tm2Rko/Notch1tm4(cre)Rko
involves: 129X1/SvJ * C57BL/6
|
abnormal vitelline vasculature morphology |
J:171829
|
|
embryonic lethality during organogenesis, complete penetrance |
J:171829
|
Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
involves: 129X1/SvJ * C57BL/6J * SJL
|
embryonic lethality during organogenesis, complete penetrance |
J:119910
|
Notch1tm5(cre/ERT2)Rko/Notch1tm5(cre/ERT2)Rko
involves: C57BL/6NTac
|
embryonic lethality during organogenesis |
J:101977
|
Tg(LckNotch1)9Erob/?
involves: C57BL/6 * CBA/J
|
abnormal CD8-positive, alpha-beta T cell differentiation |
J:93005
|
|
abnormal thymus cell ratio |
J:93005
|
|
decreased CD4-positive, alpha-beta T cell number |
J:93005
|
|
increased CD8-positive, alpha-beta T cell number |
J:93005
|
|
increased T cell derived lymphoma incidence |
J:93005
|
Tg(Notch1)1Anc/0
Not Specified
|
curly vibrissae |
J:65042
|
|
focal hair loss |
J:65042
|
|
short vibrissae |
J:65042
|
|
waved hair |
J:65042
|
Tg(Notch1)A3Rko/0
involves: FVB/N
|
no abnormal phenotype detected |
J:62217
|
Tg(Notch1)A4Rko/0
involves: FVB/N
|
no abnormal phenotype detected |
J:62217
|
Tg(Notch1)A5Rko/0
involves: FVB/N
|
alopecia |
J:62217
|
|
curly vibrissae |
J:62217
|
|
decreased curvature of zigzag hairs |
J:62217
|
|
deformed nails |
J:62217
|
|
waved hair |
J:62217
|
Tg(Notch1)A7Rko/0
involves: FVB/N
|
alopecia |
J:62217
|
|
curly vibrissae |
J:62217
|
|
decreased curvature of zigzag hairs |
J:62217
|
|
deformed nails |
J:62217
|
|
waved hair |
J:62217
|
Excel File
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