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Albtm1(cre/ERT2)Mtz
Targeted Allele Detail
Summary
Symbol: Albtm1(cre/ERT2)Mtz
Name: albumin; targeted mutation 1, Daniel Metzger
MGI ID: MGI:3052812
Synonyms: Alb-CreERT2, AlbCre-ERT2ki, AlbICE, Albtm1(cre/ESR1)Mtz, Albumin-CreER, SACre-ERT2, SA-CRE-ERT2
Gene: Alb  Location: Chr5:90608756-90624461 bp, + strand  Genetic Position: Chr5, 44.7 cM
Alliance: Albtm1(cre/ERT2)Mtz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92298
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Albtm1(cre/ERT2)Mtz expression driven by 1 gene
 
Mutation detailsA vector was used to insert IRES-Cre-ERT2 downstream of the stop codon in exon 14. Transient FLP-recombinase excised a FRT-floxed neo 3' to the Cre. ES cell clone XF136.64 was injected into blastocysts to generated mice. Southern blot confirmed recombination. RT-PCR indicated bicistronic expression was only present in the liver of mutants. Immunohistochemical analysis of liver using an anti-Cre antibody showed that Cre is expressed in most, if not all, hepatocytes. (J:92298)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Alb (mouse)
Summary of all recombinase alleles driven by Alb.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Albtm1(cre/ERT2)Mtz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Alb Mutation:  94 strains or lines available
References
Original:  J:92298 Schuler M, et al., Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis. 2004 Jul;39(3):167-72
All:  101 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory