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Targeted Allele Detail
Symbol: Albtm1(cre/ERT2)Mtz
Name: albumin; targeted mutation 1, Daniel Metzger
MGI ID: MGI:3052812
Synonyms: Alb-CreERT2, AlbCre-ERT2ki, AlbICE, Albtm1(cre/ESR1)Mtz, Albumin-CreER, SACre-ERT2, SA-CRE-ERT2
Gene: Alb  Location: Chr5:90608756-90624461 bp, + strand  Genetic Position: Chr5, 44.7 cM
Alliance: Albtm1(cre/ERT2)Mtz page
Germline Transmission:  Earliest citation of germline transmission: J:92298
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Albtm1(cre/ERT2)Mtz expression driven by 1 gene
Mutation detailsA vector was used to insert IRES-Cre-ERT2 downstream of the stop codon in exon 14. Transient FLP-recombinase excised a FRT-floxed neo 3' to the Cre. ES cell clone XF136.64 was injected into blastocysts to generated mice. Southern blot confirmed recombination. RT-PCR indicated bicistronic expression was only present in the liver of mutants. Immunohistochemical analysis of liver using an anti-Cre antibody showed that Cre is expressed in most, if not all, hepatocytes. (J:92298)
 Tissue activity of this recombinase allele
Driver: Alb (mouse)
Summary of all recombinase alleles driven by Alb.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Albtm1(cre/ERT2)Mtz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Alb Mutation:  94 strains or lines available
Original:  J:92298 Schuler M, et al., Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis. 2004 Jul;39(3):167-72
All:  101 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory