Notch1^tm1Rko
Targeted Allele Detail

Summary

• Symbol: Notch1^tm1Rko
• Name: notch 1; targeted mutation 1, Raphael Kopan
• MGI ID: MGI:1913189
• Synonyms: N1V1744G, N1^V-Glox, Notch1^tm1Kop
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm1Rko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62882
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Introduction of a point mutation in codon 1744 converting GTG (valine) to GGG (glycine) in exon F. This mutation is predicted to eliminate proteolytic processing of Notch1. There is also a 42 bp pLox site insertion in the intron between exons E and F. (J:62882)

Expression

In Mice Carrying this Mutation:	18 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 115 strains or lines available

References

• Original: J:62882 Huppert SS, et al., Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 2000 Jun 22;405(6789):966-70
• All: 4 reference(s)