Phenotypes associated with this allele

• Allele Symbol: Notch1^tm1Rko
• Allele Name: targeted mutation 1, Raphael Kopan
• Allele ID: MGI:1913189
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch1^tm1Rko/Notch1^tm1Rko	involves: 129X1/SvJ	MGI:2175159

Genotype
MGI:2175159

hm1

• Allelic Composition: Notch1^tm1Rko/Notch1^tm1Rko
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:62882 )

• embryo absorption is seen between E10 and E12

embryo

absent vitelline blood vessels ( J:62882 )

• embryos lack vascular morphogenesis at E9.5 in the yolk sac

abnormal rostral-caudal axis patterning ( J:62882 )

• mutants exhibit a variable deficit in posterior development

embryonic growth arrest ( J:62882 )

• arrest at the 19 - 23 somite stage

embryonic growth retardation ( J:62882 )

• E9.5 embryos form 19-23 somites compared to 22-16 somites in controls

kinked neural tube ( J:62882 )

• 14 of 22 embryos show neural tube kinks anterior to the forelimb

abnormal somite development ( J:62882 )

• incomplete somite differentiation: metameric repeated pattern of anterior somites is poorly maintained

growth/size/body

embryonic growth retardation ( J:62882 )

• E9.5 embryos form 19-23 somites compared to 22-16 somites in controls

cardiovascular system

absent vitelline blood vessels ( J:62882 )

• embryos lack vascular morphogenesis at E9.5 in the yolk sac

distended pericardium ( J:62882 )

• at E10.5

nervous system

kinked neural tube ( J:62882 )

• 14 of 22 embryos show neural tube kinks anterior to the forelimb