Notch1tm1.1(cre/ERT2)Sat
Targeted Allele Detail
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Symbol: |
Notch1tm1.1(cre/ERT2)Sat |
Name: |
notch 1; targeted mutation 1.1, Spyros Artavanis-Tsakonas |
MGI ID: |
MGI:5304912 |
Synonyms: |
Ni-CreERT2SAT |
Gene: |
Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
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Alliance: |
Notch1tm1.1(cre/ERT2)Sat page
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Germline Transmission: |
Earliest citation of germline transmission:
J:179631
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intergenic deletion
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Notch1tm1.1(cre/ERT2)Sat expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Notch1 (MGI:97363) |
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Mutation details: A targeting vector was constructed to insert the cre/ERT2 coding sequence, a polyadenylation signal and an Frt-flanked neo selection cassette in-frame with the start codon of Notch 1, by homologous recombination in ES cells. This resulted in deletion of most of exon 1. Chimeric males were bred to Flpe-expressing females to remove the selection cassette. Mice homozygous for this allele die embryonically.
(J:179632)
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Generation of the various Notch knock-in mice |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Notch1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Notch1 Mutation: |
115 strains or lines available
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Original: |
J:179632 Fre S, et al., Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One. 2011;6(10):e25785 |
All: |
6 reference(s) |
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