Molecular Image Detail

Image

Caption

Generation of the Notch1^{tm1.1(cre/ERT2)Sat}, Notch2^{tm1.1(cre/ERT2)Sat}, Notch3^{tm1.1(cre/ERT2)Sat} and Notch4^{tm1.1(cre/ERT2)Sat} alleles. A) Schematic representation of the knock-in strategy. The targeting allele contains the CreERT2 gene and a polyadenylation signal (pA) placed in frame with the start codon of each Notch gene, replacing much of the ORF. In each of the four N(1-4)-CreERT2SAT knock-in (KI) strains, one allele of the targeted locus expresses the CreERT2 fusion protein under the control of the corresponding Notch paralogue promoter. Blue boxes represent exons.

This image is from Fre S, PLoS One 2011;6(10):e25785, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179632

Associated
Alleles

Symbol	Name
Notch1^{tm1.1(cre/ERT2)Sat}	notch 1; targeted mutation 1.1, Spyros Artavanis-Tsakonas
Notch2^{tm1.1(cre/ERT2)Sat}	notch 2; targeted mutation 1.1, Spyros Artavanis-Tsakonas
Notch3^{tm1.1(cre/ERT2)Sat}	notch 3; targeted mutation 1.1, Spyros Artavanis-Tsakonas
Notch4^{tm1.1(cre/ERT2)Sat}	notch 4; targeted mutation 1.1, Spyros Artavanis-Tsakonas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23