Tg(Notch1)A4Rko
Transgene Detail

Summary

• Symbol: Tg(Notch1)A4Rko
• Name: transgene insertion A4, Raphael Kopan
• MGI ID: MGI:1926629
• Synonyms: MHKA-Notch^deltaE
• Transgene: Tg(Notch1)A4Rko Location: unknown
• Alliance: Tg(Notch1)A4Rko page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Notch1)A4Rko expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch1 (MGI:97363)

• Mutation details: Overexpression of a truncated, activated form of Myc-tagged Notch1 in precursor and differentiating cells of the hair cortex, driven by the mouse hair keratin A1 (Krt1) gene. 40 copies of the gene were inserted, as estimated by southern blotting. (J:62217)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:62217 Lin MH, et al., Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development. 2000 Jun;127(11):2421-32
• All: 1 reference(s)