Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SHH
  • Mouse genes Shh
  • Rat genes Shh
  • Zfish genes shha,shhb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Shh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	SHH	IDA		Human	PMID:19561609
Molecular Function	GO:0140853	cholesterol-protein transferase activity	Shh	IDA		Mouse	MGI:MGI:7310369|PMID:8824192
Molecular Function	GO:0005539	glycosaminoglycan binding	Shh	IDA		Mouse	PMID:11476578
Molecular Function	GO:0043237	laminin-1 binding	Shh	IDA		Mouse	PMID:15056720
Molecular Function	GO:0005113	patched binding	SHH	IDA		Human	PMID:11472839
Molecular Function	GO:0005113	patched binding	SHH	IDA		Human	PMID:8906787
Molecular Function	GO:0005113	patched binding	Shh	IPI	UniProtKB:Q61115	Mouse	MGI:MGI:3687672|PMID:10500113
Molecular Function	GO:0005113	patched binding	Shh	IPI	UniProtKB:Q13635|UniProtKB:Q9Y6C5	Mouse	MGI:MGI:1313055|PMID:9811851
Molecular Function	GO:0008233	peptidase activity	Shh	IDA		Mouse	MGI:MGI:7310369|PMID:8824192
Molecular Function	GO:0005515	protein binding	SHH	IPI	UniProtKB:Q13635	Human	PMID:19561609
Molecular Function	GO:0005515	protein binding	SHH	IPI	UniProtKB:Q96QV1	Human	PMID:19561609
Molecular Function	GO:0005515	protein binding	SHH	IPI	UniProtKB:Q13635-1	Human	PMID:29954986
Molecular Function	GO:0005515	protein binding	SHH	IPI	UniProtKB:Q13635-1	Human	PMID:29995851
Molecular Function	GO:0005515	protein binding	SHH	IPI	UniProtKB:Q13635-1	Human	PMID:30139912
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:Q61115	Mouse	MGI:MGI:3687672|PMID:10500113
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:Q01721	Mouse	MGI:MGI:4357747|PMID:19478089
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:Q96QV1	Mouse	MGI:MGI:5285170|PMID:19561611
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:Q9D1G3	Mouse	MGI:MGI:3772109|PMID:18081866
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:Q4KMG0	Mouse	MGI:MGI:5915624|PMID:18794898
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:Q96QV1-1	Mouse	MGI:MGI:5285170|PMID:19561611
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:Q4KMG0	Mouse	MGI:MGI:6189388|PMID:20519495
Molecular Function	GO:0005515	protein binding	Shh	IPI	UniProtKB:C0HL13	Mouse	MGI:MGI:6094409|PMID:11964399
Molecular Function	GO:0005515	protein binding	Shh	IPI	PR:Q6AZB0	Mouse	PMID:17086203
Molecular Function	GO:0005515	protein binding	Shh	IPI	PR:Q8CFZ4	Mouse	PMID:18477453
Molecular Function	GO:0005515	protein binding	Shh	IPI	PR:Q61115	Mouse	PMID:29118110
Molecular Function	GO:0005515	protein binding	Shh	IPI	PR:Q32MD9	Mouse	PMID:17086203
Molecular Function	GO:0005515	protein binding	Shh	IPI	RGD:2280	Rat	PMID:19139721|RGD:2306293
Molecular Function	GO:0008270	zinc ion binding	SHH	IDA		Human	PMID:19561609
Cellular Component	GO:0030424	axon	Shh	IDA		Rat	PMID:21182949|RGD:5509862
Cellular Component	GO:0009986	cell surface	Shh	IDA		Mouse	PMID:15576403
Cellular Component	GO:0062023	collagen-containing extracellular matrix	SHH	HDA		Human	PMID:28344315
Cellular Component	GO:0030425	dendrite	Shh	IDA		Rat	PMID:21182949|RGD:5509862
Cellular Component	GO:0005783	endoplasmic reticulum	SHH	IDA		Human	PMID:18534984
Cellular Component	GO:0005783	endoplasmic reticulum	Shh	IDA		Rat	PMID:19139721|RGD:2306293
Cellular Component	GO:0031012	extracellular matrix	Shh	IDA		Mouse	PMID:11476578
Cellular Component	GO:0005615	extracellular space	SHH	IDA		Human	PMID:19561609
Cellular Component	GO:0005615	extracellular space	Shh	IDA		Mouse	PMID:25639508
Cellular Component	GO:0005615	extracellular space	Shh	IDA		Mouse	PMID:10027293
Cellular Component	GO:0005615	extracellular space	Shh	IDA		Mouse	PMID:7891723
Cellular Component	GO:0005615	extracellular space	Shh	IDA		Rat	PMID:19139721|RGD:2306293
Cellular Component	GO:0005615	extracellular space	Shh	IDA		Rat	PMID:21182949|RGD:5509862
Cellular Component	GO:0005794	Golgi apparatus	SHH	IDA		Human	PMID:18534984
Cellular Component	GO:0005794	Golgi apparatus	Shh	IDA		Rat	PMID:19139721|RGD:2306293
Cellular Component	GO:0016020	membrane	Shh	IDA		Mouse	PMID:18477453
Cellular Component	GO:0045121	membrane raft	Shh	IDA		Mouse	PMID:15075292
Cellular Component	GO:0045121	membrane raft	Shh	IDA		Rat	PMID:19139721|RGD:2306293
Cellular Component	GO:0043025	neuronal cell body	Shh	IDA		Rat	PMID:21182949|RGD:5509862
Cellular Component	GO:0005634	nucleus	Shh	IDA		Rat	PMID:26210874|RGD:12832755
Cellular Component	GO:0008021	synaptic vesicle	Shh	IDA		Rat	PMID:28262835|RGD:12880019
Cellular Component	GO:0030133	transport vesicle	Shh	IDA		Rat	PMID:19139721|RGD:2306293
Biological Process	GO:0021984	adenohypophysis development	shha	IDA		Zfish	PMID:12606279
Biological Process	GO:0021984	adenohypophysis development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:12606280
Biological Process	GO:0021984	adenohypophysis development	shha	IMP	ZFIN:ZDB-GENO-010427-4	Zfish	PMID:12606279
Biological Process	GO:0046632	alpha-beta T cell differentiation	Shh	IMP		Mouse	PMID:10981962
Biological Process	GO:0071929	alpha-tubulin acetylation	Shh	IDA		Mouse	PMID:27793670
Biological Process	GO:0048856	anatomical structure development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11485934
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:9768363
Biological Process	GO:0008209	androgen metabolic process	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15013801
Biological Process	GO:0001525	angiogenesis	Shh	IGI	MGI:MGI:95516	Mouse	PMID:17187775
Biological Process	GO:0001525	angiogenesis	Shh	IDA		Mouse	PMID:16778080
Biological Process	GO:0001525	angiogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:17187775
Biological Process	GO:0048645	animal organ formation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15013801
Biological Process	GO:0009952	anterior/posterior pattern specification	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11118883
Biological Process	GO:0009952	anterior/posterior pattern specification	shha	IGI	ZFIN:ZDB-GENO-010426-2,ZFIN:ZDB-GENO-980202-1194	Zfish	PMID:12588855
Biological Process	GO:0009952	anterior/posterior pattern specification	shha	IMP		Zfish	PMID:10518498
Biological Process	GO:0097190	apoptotic signaling pathway	Shh	IDA		Mouse	MGI:MGI:5559673|PMID:11044396
Biological Process	GO:0060840	artery development	Shh	IGI	MGI:MGI:95729	Mouse	PMID:16968815
Biological Process	GO:0060840	artery development	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:16968815
Biological Process	GO:0048708	astrocyte differentiation	Shh	IMP		Mouse	PMID:10357934
Biological Process	GO:0007411	axon guidance	Shh	IDA		Mouse	PMID:12679031
Biological Process	GO:0007411	axon guidance	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:15065125
Biological Process	GO:0007411	axon guidance	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:12756179
Biological Process	GO:0007411	axon guidance	shha	IMP	ZFIN:ZDB-GENO-091109-1	Zfish	PMID:19846707
Biological Process	GO:0060020	Bergmann glial cell differentiation	Shh	IDA		Mouse	PMID:10375501
Biological Process	GO:0008015	blood circulation	shha	IMP	ZFIN:ZDB-GENO-980410-268	Zfish	PMID:9007249
Biological Process	GO:0007596	blood coagulation	Shh	IMP	MGI:MGI:1860897	Mouse	PMID:8835524
Biological Process	GO:0007420	brain development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:12843251
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15936751
Biological Process	GO:0060442	branching involved in prostate gland morphogenesis	Shh	IDA		Mouse	PMID:10208740
Biological Process	GO:0060445	branching involved in salivary gland morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15042696
Biological Process	GO:0060445	branching involved in salivary gland morphogenesis	Shh	IGI	MGI:MGI:99604	Mouse	PMID:15042696
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16396903
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:9768363
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15042696
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Shh	IMP	MGI:MGI:1934268,MGI:MGI:2679524	Mouse	PMID:15305287
Biological Process	GO:0060447	bud outgrowth involved in lung branching	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0043010	camera-type eye development	Shh	IMP	MGI:MGI:1934268,MGI:MGI:3052661	Mouse	PMID:16236765
Biological Process	GO:0043010	camera-type eye development	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:12756179
Biological Process	GO:0043010	camera-type eye development	Shh	IGI	MGI:MGI:95729	Mouse	PMID:18582859
Biological Process	GO:0043010	camera-type eye development	Shh	IDA		Mouse	PMID:12195432
Biological Process	GO:0043010	camera-type eye development	shha	IDA		Zfish	PMID:15728669
Biological Process	GO:0060070	canonical Wnt signaling pathway	Shh	IMP		Mouse	PMID:17284610
Biological Process	GO:0010002	cardioblast differentiation	shha	IMP		Zfish	PMID:18842815
Biological Process	GO:0035143	caudal fin morphogenesis	shha	IMP	ZFIN:ZDB-GENO-080418-2	Zfish	PMID:17597528
Biological Process	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	SHH	IDA		Human	PMID:17227833
Biological Process	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	Shh	IMP		Mouse	MGI:MGI:3834308|PMID:17227833
Biological Process	GO:0048468	cell development	Shh	IMP	MGI:MGI:1934268,MGI:MGI:3052661	Mouse	PMID:16236765
Biological Process	GO:0048468	cell development	Shh	IMP	MGI:MGI:2387802	Mouse	PMID:15183722
Biological Process	GO:0048468	cell development	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:15183722
Biological Process	GO:0045165	cell fate commitment	Shh	IGI	MGI:MGI:95655	Mouse	PMID:17504941
Biological Process	GO:0001708	cell fate specification	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:12231626
Biological Process	GO:0001708	cell fate specification	Shh	IGI	MGI:MGI:1926387	Mouse	PMID:16647304
Biological Process	GO:0001708	cell fate specification	Shh	IDA		Mouse	PMID:18076286
Biological Process	GO:0001708	cell fate specification	shha	IMP		Zfish	PMID:15229178
Biological Process	GO:0016477	cell migration	Shh	IDA		Mouse	PMID:15337776
Biological Process	GO:0008283	cell population proliferation	Shh	IGI	MGI:MGI:95728	Mouse	PMID:15496441
Biological Process	GO:0008283	cell population proliferation	Shh	IMP	MGI:MGI:1934268,MGI:MGI:3052661	Mouse	PMID:16236765
Biological Process	GO:0008283	cell population proliferation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16396903
Biological Process	GO:0008283	cell population proliferation	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:15183722
Biological Process	GO:0008283	cell population proliferation	Shh	IMP	MGI:MGI:2387802	Mouse	PMID:15183722
Biological Process	GO:0008283	cell population proliferation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16054035
Biological Process	GO:0008283	cell population proliferation	Shh	IGI	MGI:MGI:95728	Mouse	PMID:16054035
Biological Process	GO:0008283	cell population proliferation	Shh	IGI	MGI:MGI:95728	Mouse	PMID:19056373
Biological Process	GO:0021924	cell proliferation in external granule layer	Shh	IDA		Mouse	PMID:10970885
Biological Process	GO:0007267	cell-cell signaling	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16492970
Biological Process	GO:0007267	cell-cell signaling	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:15199404
Biological Process	GO:0071285	cellular response to lithium ion	Shh	IDA		Mouse	PMID:17284610
Biological Process	GO:0007417	central nervous system development	Shh	IMP		Mouse	PMID:12435628
Biological Process	GO:0007417	central nervous system development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:13129844
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	Shh	IGI	UniProtKB:P51448	Mouse	MGI:MGI:2683830|PMID:14687547
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	Shh	IDA		Mouse	MGI:MGI:5689090|PMID:22095825
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	Shh	IDA		Mouse	PMID:10027293
Biological Process	GO:0071679	commissural neuron axon guidance	Shh	IMP		Rat	PMID:19946319|RGD:12879429
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	Shh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0007368	determination of left/right symmetry	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10411502
Biological Process	GO:0007368	determination of left/right symmetry	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10385121
Biological Process	GO:0007368	determination of left/right symmetry	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10500184
Biological Process	GO:0007368	determination of left/right symmetry	shha	IDA		Zfish	PMID:9334285
Biological Process	GO:0048589	developmental growth	Shh	IMP	MGI:MGI:1934268,MGI:MGI:2445832	Mouse	PMID:11044393
Biological Process	GO:0021536	diencephalon development	shha	IGI	ZFIN:ZDB-GENO-070406-1,ZFIN:ZDB-MRPHLNO-070522-3	Zfish	PMID:18358464
Biological Process	GO:0007502	digestive tract mesoderm development	Shh	IDA		Rat	PMID:9368764|RGD:2306312
Biological Process	GO:0048546	digestive tract morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Shh	IMP		Mouse	MGI:MGI:4888042|PMID:21209331
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Shh	IDA		Mouse	PMID:18590716
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Shh	IDA		Mouse	PMID:17442700
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Shh	IGI	MGI:MGI:95655	Mouse	PMID:17504941
Biological Process	GO:0009953	dorsal/ventral pattern formation	Shh	IGI	MGI:MGI:1932386	Mouse	PMID:21552265
Biological Process	GO:0009953	dorsal/ventral pattern formation	Shh	IGI	MGI:MGI:1916147	Mouse	PMID:15269168
Biological Process	GO:0009953	dorsal/ventral pattern formation	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15539490
Biological Process	GO:0007398	ectoderm development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11118883
Biological Process	GO:0009790	embryo development	Shh	IGI	MGI:MGI:104719	Mouse	PMID:16020517
Biological Process	GO:0009790	embryo development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:17881493
Biological Process	GO:0031076	embryonic camera-type eye development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15857917
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:10821773
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:19123126
Biological Process	GO:0042733	embryonic digit morphogenesis	Shh	IMP		Mouse	MGI:MGI:5559673|PMID:11044396
Biological Process	GO:0042733	embryonic digit morphogenesis	Shh	IGI	MGI:MGI:95655	Mouse	PMID:17504941
Biological Process	GO:0042733	embryonic digit morphogenesis	Shh	IGI	MGI:MGI:98715	Mouse	PMID:15930098
Biological Process	GO:0042733	embryonic digit morphogenesis	Shh	IGI	MGI:MGI:95655	Mouse	PMID:17504940
Biological Process	GO:0042733	embryonic digit morphogenesis	Shh	IMP		Mouse	PMID:20660756
Biological Process	GO:0048617	embryonic foregut morphogenesis	Shh	IMP		Mouse	PMID:9731532
Biological Process	GO:0048617	embryonic foregut morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11476582
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11118883
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11118883
Biological Process	GO:0030326	embryonic limb morphogenesis	Shh	IGI	MGI:MGI:95729	Mouse	PMID:19422820
Biological Process	GO:0030326	embryonic limb morphogenesis	Shh	IGI	MGI:MGI:97169	Mouse	PMID:19422820
Biological Process	GO:0030326	embryonic limb morphogenesis	Shh	IGI	MGI:MGI:105373	Mouse	PMID:11389830
Biological Process	GO:0030326	embryonic limb morphogenesis	Shh	IMP	MGI:MGI:3053959,MGI:MGI:3053960	Mouse	PMID:15315763
Biological Process	GO:0030326	embryonic limb morphogenesis	Shh	IGI	MGI:MGI:97168	Mouse	PMID:19422820
Biological Process	GO:0048598	embryonic morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16492970
Biological Process	GO:0048598	embryonic morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:17881493
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	shha	IMP	ZFIN:ZDB-GENO-980410-268	Zfish	PMID:16049113
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	shha	IGI	ZFIN:ZDB-MRPHLNO-041129-2,ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:16049113
Biological Process	GO:0048702	embryonic neurocranium morphogenesis	shhb	IGI	ZFIN:ZDB-MRPHLNO-041129-2,ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:16049113
Biological Process	GO:0048568	embryonic organ development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15680353
Biological Process	GO:0048706	embryonic skeletal system development	Shh	IGI	MGI:MGI:95655	Mouse	PMID:17504941
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	shha	IMP	ZFIN:ZDB-GENO-010427-4	Zfish	PMID:16580747
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	shha	IGI	ZFIN:ZDB-MRPHLNO-041129-2,ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:16481351
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	shhb	IGI	ZFIN:ZDB-MRPHLNO-041129-2,ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:16481351
Biological Process	GO:0060956	endocardial cell differentiation	shha	IGI	ZFIN:ZDB-MRPHLNO-041129-1,ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:22119054
Biological Process	GO:0060956	endocardial cell differentiation	shhb	IGI	ZFIN:ZDB-MRPHLNO-041129-1,ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:22119054
Biological Process	GO:0031018	endocrine pancreas development	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:11900460
Biological Process	GO:0031018	endocrine pancreas development	shha	IDA		Zfish	PMID:11900460
Biological Process	GO:0006897	endocytosis	Shh	IDA		Mouse	PMID:18477453
Biological Process	GO:0050673	epithelial cell proliferation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16054035
Biological Process	GO:0050673	epithelial cell proliferation	Shh	IGI	MGI:MGI:95728	Mouse	PMID:16054035
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	Shh	IMP		Mouse	PMID:12221011
Biological Process	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	Shh	IMP		Mouse	PMID:15042696
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10500184
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Shh	IEP		Rat	PMID:8769111|RGD:2306315
Biological Process	GO:0060684	epithelial-mesenchymal cell signaling	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:19304890
Biological Process	GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development	SHH	IDA		Human	PMID:12221011
Biological Process	GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development	Shh	IGI	MGI:MGI:1347472	Mouse	PMID:15987773
Biological Process	GO:0090162	establishment of epithelial cell polarity	Shh	IDA		Mouse	PMID:16332353
Biological Process	GO:0042462	eye photoreceptor cell development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15891769
Biological Process	GO:0042462	eye photoreceptor cell development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15253932
Biological Process	GO:0033504	floor plate development	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:10694427
Biological Process	GO:0033504	floor plate development	shha	IMP	ZFIN:ZDB-GENO-980410-268	Zfish	PMID:10694427
Biological Process	GO:0033504	floor plate development	shha	IMP	ZFIN:ZDB-GENO-070215-11	Zfish	PMID:10694427
Biological Process	GO:0021508	floor plate formation	shha	IGI	ZFIN:ZDB-GENO-070712-5	Zfish	PMID:12508225
Biological Process	GO:0021508	floor plate formation	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:10694427
Biological Process	GO:0030900	forebrain development	Shh	IGI	MGI:MGI:104719	Mouse	PMID:16020517
Biological Process	GO:0030900	forebrain development	shha	IMP	ZFIN:ZDB-GENO-010427-4	Zfish	PMID:16452095
Biological Process	GO:0030900	forebrain development	shhb	IMP	ZFIN:ZDB-MRPHLNO-060508-2	Zfish	PMID:16452095
Biological Process	GO:0021871	forebrain regionalization	Shh	IMP	MGI:MGI:3775846,MGI:MGI:3840448	Mouse	PMID:24528677
Biological Process	GO:0048859	formation of anatomical boundary	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0061196	fungiform papilla development	Shh	IMP		Rat	PMID:15581865|RGD:1580345
Biological Process	GO:0061198	fungiform papilla formation	Shh	IMP		Rat	PMID:15581865|RGD:1580345
Biological Process	GO:0061197	fungiform papilla morphogenesis	Shh	IMP		Rat	PMID:15581865|RGD:1580345
Biological Process	GO:0010467	gene expression	Shh	IMP		Mouse	PMID:21211521
Biological Process	GO:0010467	gene expression	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:23201751
Biological Process	GO:0010467	gene expression	Shh	IMP		Mouse	PMID:23201751
Biological Process	GO:0010467	gene expression	Shh	IDA		Mouse	PMID:23201751
Biological Process	GO:0010001	glial cell differentiation	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15253932
Biological Process	GO:0042063	gliogenesis	shha	IGI	ZFIN:ZDB-GENE-980526-41	Zfish	PMID:15539490
Biological Process	GO:0042063	gliogenesis	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15539490
Biological Process	GO:0042063	gliogenesis	shhb	IGI	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15539490
Biological Process	GO:0032835	glomerulus development	shha	IMP	ZFIN:ZDB-GENO-080804-4	Zfish	PMID:10885753
Biological Process	GO:0021986	habenula development	shha	IMP	ZFIN:ZDB-GENO-070215-11	Zfish	PMID:27387288
Biological Process	GO:0001942	hair follicle development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16054035
Biological Process	GO:0031069	hair follicle morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11520664
Biological Process	GO:0031069	hair follicle morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:14623238
Biological Process	GO:0031069	hair follicle morphogenesis	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:9768360
Biological Process	GO:0007507	heart development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10500184
Biological Process	GO:0007507	heart development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11172440
Biological Process	GO:0007507	heart development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15936751
Biological Process	GO:0007507	heart development	shha	IMP	ZFIN:ZDB-GENO-171114-6	Zfish	PMID:28513431
Biological Process	GO:0001947	heart looping	Shh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0001947	heart looping	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10411502
Biological Process	GO:0001947	heart looping	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10500184
Biological Process	GO:0001947	heart looping	shha	IDA		Zfish	PMID:9334285
Biological Process	GO:0030902	hindbrain development	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:15183722
Biological Process	GO:0030902	hindbrain development	Shh	IMP	MGI:MGI:2387802	Mouse	PMID:15183722
Biological Process	GO:0030902	hindbrain development	Shh	IGI	MGI:MGI:95728	Mouse	PMID:15496441
Biological Process	GO:0030902	hindbrain development	shha	IMP	ZFIN:ZDB-GENO-010427-4	Zfish	PMID:15281067
Biological Process	GO:0007442	hindgut morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11485934
Biological Process	GO:0048839	inner ear development	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:17395647
Biological Process	GO:0048839	inner ear development	Shh	IGI	MGI:MGI:95729	Mouse	PMID:17395647
Biological Process	GO:0048839	inner ear development	shha	IGI	ZFIN:ZDB-GENO-010426-2,ZFIN:ZDB-GENO-980202-1194	Zfish	PMID:12588855
Biological Process	GO:0045109	intermediate filament organization	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0001822	kidney development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11172440
Biological Process	GO:0060459	left lung development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10500184
Biological Process	GO:0060174	limb bud formation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11118883
Biological Process	GO:0060173	limb development	Shh	IGI	MGI:MGI:1329045	Mouse	PMID:19223390
Biological Process	GO:0060173	limb development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:19223390
Biological Process	GO:0097421	liver regeneration	Shh	IEP		Rat	PMID:22790641|RGD:12832760
Biological Process	GO:0030324	lung development	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:9768363
Biological Process	GO:0030324	lung development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:17187775
Biological Process	GO:0030324	lung development	Shh	IMP	MGI:MGI:1934268,MGI:MGI:2679524	Mouse	PMID:15305287
Biological Process	GO:0030324	lung development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0030324	lung development	Shh	IGI	MGI:MGI:95729	Mouse	PMID:15136151
Biological Process	GO:0030324	lung development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15136151
Biological Process	GO:0060428	lung epithelium development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0060463	lung lobe morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0060425	lung morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10500184
Biological Process	GO:0060484	lung-associated mesenchyme development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	SHH	IMP		Human	PMID:14764698
Biological Process	GO:0002320	lymphoid progenitor cell differentiation	Shh	IMP		Mouse	MGI:MGI:3029054|PMID:14764698
Biological Process	GO:0030539	male genitalia development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11684660
Biological Process	GO:0048808	male genitalia morphogenesis	Shh	IMP		Rat	PMID:12533405|RGD:2306308
Biological Process	GO:0097152	mesenchymal cell apoptotic process	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:19422820
Biological Process	GO:0010463	mesenchymal cell proliferation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0060916	mesenchymal cell proliferation involved in lung development	Shh	IDA		Mouse	PMID:9006067
Biological Process	GO:0060783	mesenchymal smoothened signaling pathway involved in prostate gland development	Shh	IMP		Mouse	PMID:12221011
Biological Process	GO:0072205	metanephric collecting duct development	SHH	IEP		Human	PMID:17850284
Biological Process	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	Shh	IMP		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:0001656	metanephros development	Shh	IMP		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:0030901	midbrain development	Shh	IGI	MGI:MGI:104719	Mouse	PMID:16020517
Biological Process	GO:0030917	midbrain-hindbrain boundary development	shha	IMP	ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:28493069
Biological Process	GO:0042694	muscle cell fate specification	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:10642786
Biological Process	GO:0007517	muscle organ development	shha	IMP	ZFIN:ZDB-GENO-070228-3	Zfish	PMID:17046741
Biological Process	GO:0045445	myoblast differentiation	Shh	IDA		Mouse	PMID:15238161
Biological Process	GO:0014902	myotube differentiation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11171399
Biological Process	GO:0014902	myotube differentiation	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0046639	negative regulation of alpha-beta T cell differentiation	Shh	IMP		Mouse	PMID:10981962
Biological Process	GO:0043066	negative regulation of apoptotic process	Shh	IDA		Mouse	MGI:MGI:5559673|PMID:11044396
Biological Process	GO:0043066	negative regulation of apoptotic process	Shh	IGI	MGI:MGI:95728	Mouse	PMID:19029980
Biological Process	GO:0043066	negative regulation of apoptotic process	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0043066	negative regulation of apoptotic process	Shh	IMP		Rat	PMID:16988214|RGD:2306300
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Shh	IMP		Mouse	PMID:17284610
Biological Process	GO:0030336	negative regulation of cell migration	Shh	IDA		Mouse	PMID:15337776
Biological Process	GO:0008285	negative regulation of cell population proliferation	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15891769
Biological Process	GO:0090370	negative regulation of cholesterol efflux	Shh	IMP		Mouse	MGI:MGI:5306540|PMID:21931618
Biological Process	GO:1904339	negative regulation of dopaminergic neuron differentiation	Shh	IMP		Mouse	MGI:MGI:3836885|PMID:19122665
Biological Process	GO:0010629	negative regulation of gene expression	Shh	IMP		Mouse	MGI:MGI:3611729|PMID:16396903
Biological Process	GO:2000357	negative regulation of kidney smooth muscle cell differentiation	Shh	IDA		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:2001054	negative regulation of mesenchymal cell apoptotic process	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:19422820
Biological Process	GO:1901215	negative regulation of neuron death	Shh	IMP		Rat	PMID:20580927|RGD:10400908
Biological Process	GO:0045665	negative regulation of neuron differentiation	Shh	IDA		Mouse	PMID:15337776
Biological Process	GO:0045665	negative regulation of neuron differentiation	Shh	IMP	MGI:MGI:1934268,MGI:MGI:3052661	Mouse	PMID:16236765
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Shh	IMP		Mouse	PMID:16611981
Biological Process	GO:0032091	negative regulation of protein binding	Shh	IDA		Mouse	PMID:35353806
Biological Process	GO:0042177	negative regulation of protein catabolic process	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16611981
Biological Process	GO:0033085	negative regulation of T cell differentiation in thymus	Shh	IMP		Mouse	PMID:10981962
Biological Process	GO:0042130	negative regulation of T cell proliferation	Shh	IMP		Mouse	PMID:10981962
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Shh	IMP		Mouse	MGI:MGI:4949552|PMID:21447550
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Shh	IDA		Mouse	PMID:9769173
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	Shh	IDA		Mouse	PMID:17284610
Biological Process	GO:2000062	negative regulation of ureter smooth muscle cell differentiation	Shh	IDA		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Shh	IDA		Mouse	PMID:9356179
Biological Process	GO:0045060	negative thymic T cell selection	Shh	IMP		Mouse	MGI:MGI:3834308|PMID:17227833
Biological Process	GO:0007399	nervous system development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:13129844
Biological Process	GO:0001755	neural crest cell migration	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15936751
Biological Process	GO:0001839	neural plate morphogenesis	shha	IMP		Zfish	PMID:16502420
Biological Process	GO:0001841	neural tube formation	Shh	IMP		Rat	PMID:8124714|RGD:69996
Biological Process	GO:0007405	neuroblast proliferation	Shh	IDA		Mouse	PMID:15337776
Biological Process	GO:0007405	neuroblast proliferation	Shh	IDA		Mouse	PMID:11748155
Biological Process	GO:0007405	neuroblast proliferation	Shh	IMP	MGI:MGI:1934268,MGI:MGI:3052661	Mouse	PMID:16236765
Biological Process	GO:0030182	neuron differentiation	Shh	IMP	MGI:MGI:1934268,MGI:MGI:3052661	Mouse	PMID:16236765
Biological Process	GO:0030182	neuron differentiation	Shh	IDA		Mouse	PMID:15337776
Biological Process	GO:0030182	neuron differentiation	shha	IMP		Zfish	PMID:16502420
Biological Process	GO:0030182	neuron differentiation	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:12843251
Biological Process	GO:0030182	neuron differentiation	shhb	IMP		Zfish	PMID:16502420
Biological Process	GO:0048663	neuron fate commitment	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:16221724
Biological Process	GO:0048663	neuron fate commitment	shha	IGI	ZFIN:ZDB-GENE-980526-41	Zfish	PMID:15539490
Biological Process	GO:0048663	neuron fate commitment	shhb	IGI	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:15539490
Biological Process	GO:0042476	odontogenesis	Shh	IDA		Mouse	PMID:10781055
Biological Process	GO:0042476	odontogenesis	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:21118524
Biological Process	GO:0042476	odontogenesis	shha	IMP	ZFIN:ZDB-MRPHLNO-050204-6	Zfish	PMID:21118524
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Shh	IMP	MGI:MGI:1934268,MGI:MGI:2445832	Mouse	PMID:11044393
Biological Process	GO:0014003	oligodendrocyte development	Shh	IDA		Mouse	PMID:8660874
Biological Process	GO:0048709	oligodendrocyte differentiation	Shh	IGI	MGI:MGI:108067	Mouse	PMID:11493571
Biological Process	GO:0048709	oligodendrocyte differentiation	Shh	IGI	MGI:MGI:108067	Mouse	PMID:11171336
Biological Process	GO:0048709	oligodendrocyte differentiation	Shh	IGI	MGI:MGI:95729	Mouse	PMID:15880651
Biological Process	GO:0048709	oligodendrocyte differentiation	shha	IMP	ZFIN:ZDB-GENO-141027-3	Zfish	PMID:23345245
Biological Process	GO:0070444	oligodendrocyte progenitor proliferation	shha	IMP	ZFIN:ZDB-GENO-141027-3	Zfish	PMID:23345245
Biological Process	GO:0002076	osteoblast development	Shh	IDA		Mouse	PMID:16880529
Biological Process	GO:0031016	pancreas development	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:11044404
Biological Process	GO:0031016	pancreas development	Shh	IGI	MGI:MGI:96533	Mouse	PMID:11044404
Biological Process	GO:0031016	pancreas development	Shh	IMP	MGI:MGI:1934261	Mouse	PMID:10821773
Biological Process	GO:0031016	pancreas development	shha	IDA		Zfish	PMID:11553330
Biological Process	GO:0031016	pancreas development	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:11553330
Biological Process	GO:0031016	pancreas development	shha	IEP		Zfish	PMID:17289013
Biological Process	GO:0007389	pattern specification process	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:12231626
Biological Process	GO:0007389	pattern specification process	Shh	IGI	MGI:MGI:95729	Mouse	PMID:14602680
Biological Process	GO:0033339	pectoral fin development	shha	IMP	ZFIN:ZDB-GENO-980410-268	Zfish	PMID:10976049
Biological Process	GO:0033339	pectoral fin development	shha	IMP		Zfish	PMID:10518498
Biological Process	GO:0033339	pectoral fin development	shha	IMP	ZFIN:ZDB-GENO-980410-268	Zfish	PMID:9655820
Biological Process	GO:0033339	pectoral fin development	shha	IMP	ZFIN:ZDB-GENO-080729-2	Zfish	PMID:9655820
Biological Process	GO:0033339	pectoral fin development	shha	IMP		Zfish	PMID:9007245
Biological Process	GO:0033339	pectoral fin development	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:10976049
Biological Process	GO:0045494	photoreceptor cell maintenance	shha	IMP	ZFIN:ZDB-GENO-091027-1	Zfish	PMID:18502998
Biological Process	GO:0045494	photoreceptor cell maintenance	shha	IMP	ZFIN:ZDB-GENO-091027-2	Zfish	PMID:18502998
Biological Process	GO:0009949	polarity specification of anterior/posterior axis	Shh	IMP		Mouse	MGI:MGI:5559673|PMID:11044396
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	Shh	IMP		Mouse	MGI:MGI:3029054|PMID:14764698
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	Shh	IMP		Mouse	PMID:10357934
Biological Process	GO:0051781	positive regulation of cell division	SHH	IDA		Human	PMID:11331587
Biological Process	GO:0008284	positive regulation of cell population proliferation	SHH	IDA		Human	PMID:11331587
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:15183722
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shh	IDA		Mouse	PMID:11748155
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shh	IGI	MGI:MGI:95728	Mouse	PMID:15496441
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16396903
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shh	IMP	MGI:MGI:2387802	Mouse	PMID:15183722
Biological Process	GO:0008284	positive regulation of cell population proliferation	Shh	IDA		Rat	PMID:9236238|RGD:2306313
Biological Process	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	Shh	IDA		Mouse	PMID:10027293
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	SHH	IDA		Human	PMID:10654605
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Shh	IDA		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Shh	IDA		Mouse	PMID:9356179
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	Shh	IDA		Rat	PMID:20052412|RGD:12879408
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:16054035
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Shh	IGI	MGI:MGI:95728	Mouse	PMID:16054035
Biological Process	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	Shh	IMP		Mouse	PMID:12221011
Biological Process	GO:0010628	positive regulation of gene expression	Shh	IMP		Mouse	MGI:MGI:3611729|PMID:16396903
Biological Process	GO:0010628	positive regulation of gene expression	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11118883
Biological Process	GO:0007228	positive regulation of hh target transcription factor activity	Shh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0007228	positive regulation of hh target transcription factor activity	Shh	IDA		Mouse	PMID:16611981
Biological Process	GO:0007228	positive regulation of hh target transcription factor activity	Shh	IGI	MGI:MGI:95728	Mouse	PMID:16880529
Biological Process	GO:0007228	positive regulation of hh target transcription factor activity	Shh	IMP		Mouse	PMID:10340755
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	Shh	IMP		Mouse	MGI:MGI:3847177|PMID:19273836
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	Shh	IMP		Mouse	MGI:MGI:3029054|PMID:14764698
Biological Process	GO:2000358	positive regulation of kidney smooth muscle cell differentiation	Shh	IDA		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	Shh	IMP		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	Shh	IDA		Mouse	PMID:11748155
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	Shh	IMP	MGI:MGI:1934268,MGI:MGI:3052661	Mouse	PMID:16236765
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	Shh	IMP		Rat	PMID:12469128|RGD:729868
Biological Process	GO:0045666	positive regulation of neuron differentiation	Shh	IMP		Rat	PMID:8124714|RGD:69996
Biological Process	GO:0032901	positive regulation of neurotrophin production	Shh	IMP		Rat	PMID:23237228|RGD:12832758
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Shh	IDA		Mouse	PMID:11171336
Biological Process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	Shh	IDA		Rat	PMID:12237843|RGD:2306309
Biological Process	GO:0060406	positive regulation of penile erection	Shh	IMP		Rat	PMID:12533405|RGD:2306308
Biological Process	GO:0046534	positive regulation of photoreceptor cell differentiation	Shh	IDA		Rat	PMID:9236238|RGD:2306313
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Shh	IGI	MGI:MGI:108075	Mouse	PMID:17043310
Biological Process	GO:0061189	positive regulation of sclerotome development	SHH	IDA		Human	PMID:10654605
Biological Process	GO:0014858	positive regulation of skeletal muscle cell proliferation	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11171399
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	SHH	IDA		Human	PMID:19561609
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	SHH	IDA		Human	PMID:24342078
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Shh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	Shh	IDA		Rat	PMID:20052412|RGD:12879408
Biological Process	GO:0051155	positive regulation of striated muscle cell differentiation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11171399
Biological Process	GO:0051155	positive regulation of striated muscle cell differentiation	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	Shh	IMP		Mouse	MGI:MGI:3836494|PMID:19109233
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IDA		Mouse	MGI:MGI:4949552|PMID:21447550
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IMP		Mouse	PMID:10340755
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IGI	MGI:MGI:96533	Mouse	PMID:17881493
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IGI	MGI:MGI:95728	Mouse	PMID:16880529
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:19304890
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IDA		Mouse	PMID:9585504
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IDA		Mouse	PMID:9006067
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IDA		Mouse	PMID:9769173
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IGI	MGI:MGI:97168	Mouse	PMID:10340755
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IDA		Mouse	PMID:11493558
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IGI	MGI:MGI:104327	Mouse	PMID:9585504
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Shh	IDA		Mouse	PMID:23740243
Biological Process	GO:2000063	positive regulation of ureter smooth muscle cell differentiation	Shh	IMP		Mouse	MGI:MGI:2388350|PMID:12399320
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11520664
Biological Process	GO:0045059	positive thymic T cell selection	Shh	IMP		Mouse	MGI:MGI:3834308|PMID:17227833
Biological Process	GO:0048618	post-embryonic foregut morphogenesis	shha	IMP	ZFIN:ZDB-GENO-010427-4	Zfish	PMID:12618131
Biological Process	GO:0060516	primary prostatic bud elongation	Shh	IDA		Mouse	PMID:10208740
Biological Process	GO:0048793	pronephros development	shha	IMP	ZFIN:ZDB-GENO-080804-4	Zfish	PMID:10885753
Biological Process	GO:0060523	prostate epithelial cord elongation	Shh	IDA		Mouse	PMID:15013801
Biological Process	GO:0030850	prostate gland development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15013801
Biological Process	GO:0030850	prostate gland development	Shh	IMP		Mouse	PMID:10208740
Biological Process	GO:0030850	prostate gland development	Shh	IEP		Rat	PMID:15328011|RGD:1303367
Biological Process	GO:0006606	protein import into nucleus	Shh	IGI	MGI:MGI:108075	Mouse	PMID:17043310
Biological Process	GO:0034504	protein localization to nucleus	Shh	IDA		Mouse	PMID:19952108
Biological Process	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	shha	IDA		Zfish	PMID:9334285
Biological Process	GO:1905178	regulation of cardiac muscle tissue regeneration	shha	IMP	ZFIN:ZDB-GENO-171114-6	Zfish	PMID:28513431
Biological Process	GO:0061035	regulation of cartilage development	shha	IGI	ZFIN:ZDB-GENO-120220-6,ZFIN:ZDB-GENO-980202-572	Zfish	PMID:22185793
Biological Process	GO:0042127	regulation of cell population proliferation	Shh	IDA		Rat	PMID:12417650|RGD:628387
Biological Process	GO:0006355	regulation of DNA-templated transcription	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11412027
Biological Process	GO:0006355	regulation of DNA-templated transcription	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0030856	regulation of epithelial cell differentiation	Shh	IEP		Rat	PMID:14651923|RGD:1580346
Biological Process	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	Shh	IMP		Mouse	PMID:12221011
Biological Process	GO:0010468	regulation of gene expression	Shh	IGI	MGI:MGI:95729	Mouse	PMID:18799682
Biological Process	GO:0010468	regulation of gene expression	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11476582
Biological Process	GO:0010468	regulation of gene expression	Shh	IDA		Mouse	PMID:22179047
Biological Process	GO:0010468	regulation of gene expression	Shh	IMP		Mouse	PMID:18799682
Biological Process	GO:0010468	regulation of gene expression	shha	IDA		Zfish	PMID:10021344|ZFIN:ZDB-PUB-990428-2
Biological Process	GO:0060251	regulation of glial cell proliferation	Shh	IDA		Mouse	PMID:12756179
Biological Process	GO:0060782	regulation of mesenchymal cell proliferation involved in prostate gland development	Shh	IMP		Mouse	PMID:12221011
Biological Process	GO:0042481	regulation of odontogenesis	Shh	IMP		Mouse	MGI:MGI:4949552|PMID:21447550
Biological Process	GO:0060685	regulation of prostatic bud formation	Shh	IMP		Mouse	PMID:12221011
Biological Process	GO:0060685	regulation of prostatic bud formation	Shh	IDA		Mouse	PMID:18393306
Biological Process	GO:1900180	regulation of protein localization to nucleus	SHH	IDA		Human	PMID:11331587
Biological Process	GO:0030162	regulation of proteolysis	Shh	IDA		Mouse	PMID:15136151
Biological Process	GO:0072091	regulation of stem cell proliferation	Shh	IMP		Mouse	PMID:12221011
Biological Process	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	shha	IMP	ZFIN:ZDB-GENO-010426-2	Zfish	PMID:12110173
Biological Process	GO:0030323	respiratory tube development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0048678	response to axon injury	Shh	IMP		Rat	PMID:15356205|RGD:1580344
Biological Process	GO:0032355	response to estradiol	Shh	IEP		Rat	PMID:15328011|RGD:1303367
Biological Process	GO:0045471	response to ethanol	Shh	IDA		Rat	PMID:19139721|RGD:2306293
Biological Process	GO:0001666	response to hypoxia	Shh	IEP		Rat	PMID:18228117|RGD:2306299
Biological Process	GO:0010243	response to organonitrogen compound	Shh	IEP		Rat	PMID:16369776|RGD:2306301
Biological Process	GO:0032526	response to retinoic acid	Shh	IEP		Rat	PMID:10633866|RGD:2306310
Biological Process	GO:0060458	right lung development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10500184
Biological Process	GO:0060021	roof of mouth development	Shh	IMP	MGI:MGI:1934268	Mouse	PMID:19304890
Biological Process	GO:0060021	roof of mouth development	Shh	IMP	MGI:MGI:2176256	Mouse	PMID:19304890
Biological Process	GO:0060662	salivary gland cavitation	Shh	IDA		Mouse	PMID:16332353
Biological Process	GO:0097264	self proteolysis	Shh	IDA		Mouse	MGI:MGI:7310369|PMID:8824192
Biological Process	GO:0014856	skeletal muscle cell proliferation	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0048741	skeletal muscle fiber development	shha	IGI	ZFIN:ZDB-MRPHLNO-070529-1,ZFIN:ZDB-MRPHLNO-070529-2,ZFIN:ZDB-MRPHLNO-070529-3,ZFIN:ZDB-MRPHLNO-070529-4	Zfish	PMID:17699609
Biological Process	GO:0048741	skeletal muscle fiber development	shha	IGI	ZFIN:ZDB-MRPHLNO-071210-2,ZFIN:ZDB-MRPHLNO-071210-3	Zfish	PMID:17699609
Biological Process	GO:0048741	skeletal muscle fiber development	shha	IDA		Zfish	PMID:17699609
Biological Process	GO:0098528	skeletal muscle fiber differentiation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:15238161
Biological Process	GO:0007519	skeletal muscle tissue development	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0007519	skeletal muscle tissue development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11171399
Biological Process	GO:0043588	skin development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:10331973
Biological Process	GO:0048745	smooth muscle tissue development	SHH	IEP		Human	PMID:17850284
Biological Process	GO:0007224	smoothened signaling pathway	SHH	IEP		Human	PMID:17850284
Biological Process	GO:0007224	smoothened signaling pathway	SHH	IDA		Human	PMID:31279575
Biological Process	GO:0007224	smoothened signaling pathway	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11118883
Biological Process	GO:0007224	smoothened signaling pathway	Shh	IDA		Mouse	PMID:25639508
Biological Process	GO:0007224	smoothened signaling pathway	Shh	IGI	MGI:MGI:1916147	Mouse	PMID:15269168
Biological Process	GO:0007224	smoothened signaling pathway	Shh	IDA		Mouse	PMID:8906787
Biological Process	GO:0007224	smoothened signaling pathway	Shh	IGI	MGI:MGI:108075	Mouse	PMID:17043310
Biological Process	GO:0007224	smoothened signaling pathway	shha	IGI	ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-120813-6,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552
Biological Process	GO:0007224	smoothened signaling pathway	shha	IGI	ZFIN:ZDB-GENO-010426-2,ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:16626681
Biological Process	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	Shh	IMP		Mouse	PMID:10375501
Biological Process	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	Shh	IDA		Mouse	PMID:10375501
Biological Process	GO:0061053	somite development	Shh	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0001756	somitogenesis	shha	IMP	ZFIN:ZDB-GENO-080729-2	Zfish	PMID:9655820
Biological Process	GO:0001756	somitogenesis	shha	IMP	ZFIN:ZDB-GENO-980410-268	Zfish	PMID:9655820
Biological Process	GO:0001756	somitogenesis	shha	IGI	ZFIN:ZDB-GENO-070406-1,ZFIN:ZDB-MRPHLNO-080924-3	Zfish	PMID:18326814
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11748151
Biological Process	GO:0021513	spinal cord dorsal/ventral patterning	Shh	IDA		Rat	PMID:9230312|RGD:8553789
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	shha	IMP	ZFIN:ZDB-GENO-070530-1	Zfish	PMID:9242415
Biological Process	GO:0021522	spinal cord motor neuron differentiation	Shh	IGI	MGI:MGI:107736	Mouse	PMID:21552265
Biological Process	GO:0048864	stem cell development	Shh	IMP		Mouse	MGI:MGI:2667422|PMID:12843296
Biological Process	GO:0072089	stem cell proliferation	Shh	IDA		Mouse	PMID:15337776
Biological Process	GO:0055002	striated muscle cell development	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:11428131
Biological Process	GO:0055002	striated muscle cell development	shhb	IGI	ZFIN:ZDB-GENO-980202-1526	Zfish	PMID:11428131
Biological Process	GO:0051146	striated muscle cell differentiation	Shh	IDA		Mouse	PMID:15238161
Biological Process	GO:0014706	striated muscle tissue development	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:11171399
Biological Process	GO:0048795	swim bladder morphogenesis	shha	IMP	ZFIN:ZDB-GENO-070406-1	Zfish	PMID:19422819
Biological Process	GO:0033077	T cell differentiation in thymus	Shh	IMP		Mouse	MGI:MGI:3847177|PMID:19273836
Biological Process	GO:0033077	T cell differentiation in thymus	Shh	IMP		Mouse	PMID:10981962
Biological Process	GO:0042098	T cell proliferation	Shh	IMP		Mouse	PMID:10981962
Biological Process	GO:0021978	telencephalon regionalization	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:11060228
Biological Process	GO:0021978	telencephalon regionalization	Shh	IMP		Rat	PMID:9811591|RGD:2306311
Biological Process	GO:0021794	thalamus development	Shh	IGI	MGI:MGI:108075	Mouse	PMID:19357274
Biological Process	GO:0021794	thalamus development	Shh	IMP	MGI:MGI:1934268,MGI:MGI:2176173	Mouse	PMID:19357274
Biological Process	GO:0048538	thymus development	Shh	IMP		Mouse	MGI:MGI:3836494|PMID:19109233
Biological Process	GO:0030878	thyroid gland development	Shh	IMP	MGI:MGI:1861186	Mouse	PMID:16968815
Biological Process	GO:0043586	tongue development	Shh	IMP		Rat	PMID:15581865|RGD:1580345
Biological Process	GO:0043587	tongue morphogenesis	Shh	IMP		Rat	PMID:15581865|RGD:1580345
Biological Process	GO:0060438	trachea development	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0060439	trachea morphogenesis	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:1905327	tracheoesophageal septum formation	Shh	IMP	MGI:MGI:1857796	Mouse	PMID:9731532
Biological Process	GO:0036484	trunk neural crest cell migration	Shh	IDA		Mouse	PMID:15337776
Biological Process	GO:0001944	vasculature development	Shh	IMP		Mouse	PMID:17881493
Biological Process	GO:0001570	vasculogenesis	Shh	IDA		Mouse	PMID:15294868
Biological Process	GO:0021521	ventral spinal cord interneuron specification	Shh	IDA		Rat	PMID:9230312|RGD:8553789
Biological Process	GO:0022006	zona limitans intrathalamica formation	Shh	IDA		Rat	PMID:25281935|RGD:12832757

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern