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Term Detail
GO term:central nervous system development
Synonym: CNS development
GO id:GO:0007417
Definition:The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
Number of paths to term: 10

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        is-aautonomic nervous system development +
                                        is-acardiovascular system development +
                                        is-acentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                part-ofastrocyte differentiation +
                                                part-ofbrain development +
                                                part-ofcentral nervous system maturation +
                                                part-ofcentral nervous system morphogenesis +
                                                part-ofcentral nervous system neuron differentiation +
                                                part-ofcentral nervous system segmentation +
                                                part-ofestablishment of endothelial blood-brain barrier +
                                                part-oflarval central nervous system remodeling
                                                part-ofmicroglia differentiation +
                                                part-ofoligodendrocyte differentiation +
                                                part-ofpreganglionic parasympathetic nervous system development +
                                                part-ofspinal cord development +
                                                part-ofventral cord development
                                                part-ofventral midline development +
                                        is-acirculatory system development +
                                        is-adigestive system development +
                                        is-aendocrine system development +
                                        is-aenteric nervous system development
                                        is-aexocrine system development +
                                        is-agenitalia development +
                                        is-ahepaticobiliary system development +
                                        is-aimmune system development +
                                        is-alimbic system development +
                                        is-anervous system development +
                                        part-oforgan development +
                                        is-aparasympathetic nervous system development +
                                        is-aperipheral nervous system development +
                                        is-apharyngeal system development +
                                        is-apostganglionic parasympathetic nervous system development
                                        is-apreganglionic parasympathetic nervous system development +
                                        is-arenal system development +
                                        is-areproductive system development +
                                        is-arespiratory system development +
                                        is-aroot system development +
                                        is-asensory system development +
                                        is-ashoot system development +
                                        is-askeletal system development +
                                        is-astomatogastric nervous system development
                                        is-asympathetic nervous system development +
                                        is-aurogenital system development +
                                        is-avasculature development +
                                        is-aventricular system development +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-asystem development
                                        is-anervous system development
                                                part-ofautonomic nervous system development +
                                                part-ofbranching morphogenesis of a nerve +
                                                part-ofcentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                        part-ofastrocyte differentiation +
                                                        part-ofbrain development +
                                                        part-ofcentral nervous system maturation +
                                                        part-ofcentral nervous system morphogenesis +
                                                        part-ofcentral nervous system neuron differentiation +
                                                        part-ofcentral nervous system segmentation +
                                                        part-ofestablishment of endothelial blood-brain barrier +
                                                        part-oflarval central nervous system remodeling
                                                        part-ofmicroglia differentiation +
                                                        part-ofoligodendrocyte differentiation +
                                                        part-ofpreganglionic parasympathetic nervous system development +
                                                        part-ofspinal cord development +
                                                        part-ofventral cord development
                                                        part-ofventral midline development +
                                                part-ofdetermination of left/right asymmetry in nervous system +
                                                part-ofensheathment of neurons +
                                                part-ofganglion development +
                                                negatively-regulatesnegative regulation of nervous system development +
                                                part-ofnerve development +
                                                part-ofneural tube development +
                                                part-ofneurogenesis +
                                                part-ofnotochord formation
                                                part-ofperipheral nervous system development +
                                                positively-regulatespositive regulation of nervous system development +
                                                part-ofprechordal plate formation
                                                regulatesregulation of nervous system development +
                                                part-ofstomatogastric nervous system development
                                                part-ofsynapse assembly +
                                                part-ofsynapse maturation +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aautonomic nervous system development +
                                                is-acardiovascular system development +
                                                is-acentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                        part-ofastrocyte differentiation +
                                                        part-ofbrain development +
                                                        part-ofcentral nervous system maturation +
                                                        part-ofcentral nervous system morphogenesis +
                                                        part-ofcentral nervous system neuron differentiation +
                                                        part-ofcentral nervous system segmentation +
                                                        part-ofestablishment of endothelial blood-brain barrier +
                                                        part-oflarval central nervous system remodeling
                                                        part-ofmicroglia differentiation +
                                                        part-ofoligodendrocyte differentiation +
                                                        part-ofpreganglionic parasympathetic nervous system development +
                                                        part-ofspinal cord development +
                                                        part-ofventral cord development
                                                        part-ofventral midline development +
                                                is-acirculatory system development +
                                                is-adigestive system development +
                                                is-aendocrine system development +
                                                is-aenteric nervous system development
                                                is-aexocrine system development +
                                                is-agenitalia development +
                                                is-ahepaticobiliary system development +
                                                is-aimmune system development +
                                                is-alimbic system development +
                                                is-anervous system development +
                                                part-oforgan development +
                                                is-aparasympathetic nervous system development +
                                                is-aperipheral nervous system development +
                                                is-apharyngeal system development +
                                                is-apostganglionic parasympathetic nervous system development
                                                is-apreganglionic parasympathetic nervous system development +
                                                is-arenal system development +
                                                is-areproductive system development +
                                                is-arespiratory system development +
                                                is-aroot system development +
                                                is-asensory system development +
                                                is-ashoot system development +
                                                is-askeletal system development +
                                                is-astomatogastric nervous system development
                                                is-asympathetic nervous system development +
                                                is-aurogenital system development +
                                                is-avasculature development +
                                                is-aventricular system development +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-anervous system development
                                                        part-ofautonomic nervous system development +
                                                        part-ofbranching morphogenesis of a nerve +
                                                        part-ofcentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                                part-ofastrocyte differentiation +
                                                                part-ofbrain development +
                                                                part-ofcentral nervous system maturation +
                                                                part-ofcentral nervous system morphogenesis +
                                                                part-ofcentral nervous system neuron differentiation +
                                                                part-ofcentral nervous system segmentation +
                                                                part-ofestablishment of endothelial blood-brain barrier +
                                                                part-oflarval central nervous system remodeling
                                                                part-ofmicroglia differentiation +
                                                                part-ofoligodendrocyte differentiation +
                                                                part-ofpreganglionic parasympathetic nervous system development +
                                                                part-ofspinal cord development +
                                                                part-ofventral cord development
                                                                part-ofventral midline development +
                                                        part-ofdetermination of left/right asymmetry in nervous system +
                                                        part-ofensheathment of neurons +
                                                        part-ofganglion development +
                                                        negatively-regulatesnegative regulation of nervous system development +
                                                        part-ofnerve development +
                                                        part-ofneural tube development +
                                                        part-ofneurogenesis +
                                                        part-ofnotochord formation
                                                        part-ofperipheral nervous system development +
                                                        positively-regulatespositive regulation of nervous system development +
                                                        part-ofprechordal plate formation
                                                        regulatesregulation of nervous system development +
                                                        part-ofstomatogastric nervous system development
                                                        part-ofsynapse assembly +
                                                        part-ofsynapse maturation +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aautonomic nervous system development +
                                                is-acardiovascular system development +
                                                is-acentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                        part-ofastrocyte differentiation +
                                                        part-ofbrain development +
                                                        part-ofcentral nervous system maturation +
                                                        part-ofcentral nervous system morphogenesis +
                                                        part-ofcentral nervous system neuron differentiation +
                                                        part-ofcentral nervous system segmentation +
                                                        part-ofestablishment of endothelial blood-brain barrier +
                                                        part-oflarval central nervous system remodeling
                                                        part-ofmicroglia differentiation +
                                                        part-ofoligodendrocyte differentiation +
                                                        part-ofpreganglionic parasympathetic nervous system development +
                                                        part-ofspinal cord development +
                                                        part-ofventral cord development
                                                        part-ofventral midline development +
                                                is-acirculatory system development +
                                                is-adigestive system development +
                                                is-aendocrine system development +
                                                is-aenteric nervous system development
                                                is-aexocrine system development +
                                                is-agenitalia development +
                                                is-ahepaticobiliary system development +
                                                is-aimmune system development +
                                                is-alimbic system development +
                                                is-anervous system development +
                                                part-oforgan development +
                                                is-aparasympathetic nervous system development +
                                                is-aperipheral nervous system development +
                                                is-apharyngeal system development +
                                                is-apostganglionic parasympathetic nervous system development
                                                is-apreganglionic parasympathetic nervous system development +
                                                is-arenal system development +
                                                is-areproductive system development +
                                                is-arespiratory system development +
                                                is-aroot system development +
                                                is-asensory system development +
                                                is-ashoot system development +
                                                is-askeletal system development +
                                                is-astomatogastric nervous system development
                                                is-asympathetic nervous system development +
                                                is-aurogenital system development +
                                                is-avasculature development +
                                                is-aventricular system development +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-anervous system development
                                                        part-ofautonomic nervous system development +
                                                        part-ofbranching morphogenesis of a nerve +
                                                        part-ofcentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                                part-ofastrocyte differentiation +
                                                                part-ofbrain development +
                                                                part-ofcentral nervous system maturation +
                                                                part-ofcentral nervous system morphogenesis +
                                                                part-ofcentral nervous system neuron differentiation +
                                                                part-ofcentral nervous system segmentation +
                                                                part-ofestablishment of endothelial blood-brain barrier +
                                                                part-oflarval central nervous system remodeling
                                                                part-ofmicroglia differentiation +
                                                                part-ofoligodendrocyte differentiation +
                                                                part-ofpreganglionic parasympathetic nervous system development +
                                                                part-ofspinal cord development +
                                                                part-ofventral cord development
                                                                part-ofventral midline development +
                                                        part-ofdetermination of left/right asymmetry in nervous system +
                                                        part-ofensheathment of neurons +
                                                        part-ofganglion development +
                                                        negatively-regulatesnegative regulation of nervous system development +
                                                        part-ofnerve development +
                                                        part-ofneural tube development +
                                                        part-ofneurogenesis +
                                                        part-ofnotochord formation
                                                        part-ofperipheral nervous system development +
                                                        positively-regulatespositive regulation of nervous system development +
                                                        part-ofprechordal plate formation
                                                        regulatesregulation of nervous system development +
                                                        part-ofstomatogastric nervous system development
                                                        part-ofsynapse assembly +
                                                        part-ofsynapse maturation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aautonomic nervous system development +
                                                is-acardiovascular system development +
                                                is-acentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                        part-ofastrocyte differentiation +
                                                        part-ofbrain development +
                                                        part-ofcentral nervous system maturation +
                                                        part-ofcentral nervous system morphogenesis +
                                                        part-ofcentral nervous system neuron differentiation +
                                                        part-ofcentral nervous system segmentation +
                                                        part-ofestablishment of endothelial blood-brain barrier +
                                                        part-oflarval central nervous system remodeling
                                                        part-ofmicroglia differentiation +
                                                        part-ofoligodendrocyte differentiation +
                                                        part-ofpreganglionic parasympathetic nervous system development +
                                                        part-ofspinal cord development +
                                                        part-ofventral cord development
                                                        part-ofventral midline development +
                                                is-acirculatory system development +
                                                is-adigestive system development +
                                                is-aendocrine system development +
                                                is-aenteric nervous system development
                                                is-aexocrine system development +
                                                is-agenitalia development +
                                                is-ahepaticobiliary system development +
                                                is-aimmune system development +
                                                is-alimbic system development +
                                                is-anervous system development +
                                                part-oforgan development +
                                                is-aparasympathetic nervous system development +
                                                is-aperipheral nervous system development +
                                                is-apharyngeal system development +
                                                is-apostganglionic parasympathetic nervous system development
                                                is-apreganglionic parasympathetic nervous system development +
                                                is-arenal system development +
                                                is-areproductive system development +
                                                is-arespiratory system development +
                                                is-aroot system development +
                                                is-asensory system development +
                                                is-ashoot system development +
                                                is-askeletal system development +
                                                is-astomatogastric nervous system development
                                                is-asympathetic nervous system development +
                                                is-aurogenital system development +
                                                is-avasculature development +
                                                is-aventricular system development +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-anervous system development
                                                        part-ofautonomic nervous system development +
                                                        part-ofbranching morphogenesis of a nerve +
                                                        part-ofcentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                                part-ofastrocyte differentiation +
                                                                part-ofbrain development +
                                                                part-ofcentral nervous system maturation +
                                                                part-ofcentral nervous system morphogenesis +
                                                                part-ofcentral nervous system neuron differentiation +
                                                                part-ofcentral nervous system segmentation +
                                                                part-ofestablishment of endothelial blood-brain barrier +
                                                                part-oflarval central nervous system remodeling
                                                                part-ofmicroglia differentiation +
                                                                part-ofoligodendrocyte differentiation +
                                                                part-ofpreganglionic parasympathetic nervous system development +
                                                                part-ofspinal cord development +
                                                                part-ofventral cord development
                                                                part-ofventral midline development +
                                                        part-ofdetermination of left/right asymmetry in nervous system +
                                                        part-ofensheathment of neurons +
                                                        part-ofganglion development +
                                                        negatively-regulatesnegative regulation of nervous system development +
                                                        part-ofnerve development +
                                                        part-ofneural tube development +
                                                        part-ofneurogenesis +
                                                        part-ofnotochord formation
                                                        part-ofperipheral nervous system development +
                                                        positively-regulatespositive regulation of nervous system development +
                                                        part-ofprechordal plate formation
                                                        regulatesregulation of nervous system development +
                                                        part-ofstomatogastric nervous system development
                                                        part-ofsynapse assembly +
                                                        part-ofsynapse maturation +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-aautonomic nervous system development +
                                                is-acardiovascular system development +
                                                is-acentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                        part-ofastrocyte differentiation +
                                                        part-ofbrain development +
                                                        part-ofcentral nervous system maturation +
                                                        part-ofcentral nervous system morphogenesis +
                                                        part-ofcentral nervous system neuron differentiation +
                                                        part-ofcentral nervous system segmentation +
                                                        part-ofestablishment of endothelial blood-brain barrier +
                                                        part-oflarval central nervous system remodeling
                                                        part-ofmicroglia differentiation +
                                                        part-ofoligodendrocyte differentiation +
                                                        part-ofpreganglionic parasympathetic nervous system development +
                                                        part-ofspinal cord development +
                                                        part-ofventral cord development
                                                        part-ofventral midline development +
                                                is-acirculatory system development +
                                                is-adigestive system development +
                                                is-aendocrine system development +
                                                is-aenteric nervous system development
                                                is-aexocrine system development +
                                                is-agenitalia development +
                                                is-ahepaticobiliary system development +
                                                is-aimmune system development +
                                                is-alimbic system development +
                                                is-anervous system development +
                                                part-oforgan development +
                                                is-aparasympathetic nervous system development +
                                                is-aperipheral nervous system development +
                                                is-apharyngeal system development +
                                                is-apostganglionic parasympathetic nervous system development
                                                is-apreganglionic parasympathetic nervous system development +
                                                is-arenal system development +
                                                is-areproductive system development +
                                                is-arespiratory system development +
                                                is-aroot system development +
                                                is-asensory system development +
                                                is-ashoot system development +
                                                is-askeletal system development +
                                                is-astomatogastric nervous system development
                                                is-asympathetic nervous system development +
                                                is-aurogenital system development +
                                                is-avasculature development +
                                                is-aventricular system development +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amulticellular organismal development
                                        part-ofsystem development
                                                is-anervous system development
                                                        part-ofautonomic nervous system development +
                                                        part-ofbranching morphogenesis of a nerve +
                                                        part-ofcentral nervous system development [GO:0007417] (664 genes, 1520 annotations)
                                                                part-ofastrocyte differentiation +
                                                                part-ofbrain development +
                                                                part-ofcentral nervous system maturation +
                                                                part-ofcentral nervous system morphogenesis +
                                                                part-ofcentral nervous system neuron differentiation +
                                                                part-ofcentral nervous system segmentation +
                                                                part-ofestablishment of endothelial blood-brain barrier +
                                                                part-oflarval central nervous system remodeling
                                                                part-ofmicroglia differentiation +
                                                                part-ofoligodendrocyte differentiation +
                                                                part-ofpreganglionic parasympathetic nervous system development +
                                                                part-ofspinal cord development +
                                                                part-ofventral cord development
                                                                part-ofventral midline development +
                                                        part-ofdetermination of left/right asymmetry in nervous system +
                                                        part-ofensheathment of neurons +
                                                        part-ofganglion development +
                                                        negatively-regulatesnegative regulation of nervous system development +
                                                        part-ofnerve development +
                                                        part-ofneural tube development +
                                                        part-ofneurogenesis +
                                                        part-ofnotochord formation
                                                        part-ofperipheral nervous system development +
                                                        positively-regulatespositive regulation of nervous system development +
                                                        part-ofprechordal plate formation
                                                        regulatesregulation of nervous system development +
                                                        part-ofstomatogastric nervous system development
                                                        part-ofsynapse assembly +
                                                        part-ofsynapse maturation +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory