| GO term: | myotube differentiation |
| GO id: | GO:0014902 |
| Definition: | The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. |
| Number of paths to term: | 15 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationmuscle cell differentiationstriated muscle cell differentiationskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processanatomical structure developmentmuscle structure developmentmuscle cell differentiationstriated muscle cell differentiationskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processanatomical structure developmentmuscle structure developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processanatomical structure developmenttissue developmentmuscle tissue developmentstriated muscle tissue developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processcellular developmental processcell differentiationmuscle cell differentiationstriated muscle cell differentiationskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processsingle-organism developmental processmuscle structure developmentmuscle cell differentiationstriated muscle cell differentiationskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processdevelopmental processsingle-organism developmental processmuscle structure developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationmuscle cell differentiationstriated muscle cell differentiationskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processsingle-organism processsingle-organism developmental processmuscle structure developmentmuscle cell differentiationstriated muscle cell differentiationskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +biological_processsingle-organism processsingle-organism developmental processmuscle structure developmentmuscle organ developmentskeletal muscle organ developmentskeletal muscle tissue developmentskeletal muscle cell differentiationmyotube differentiation [GO:0014902] (43 genes, 58 annotations)myoblast fusion +myotube cell development +myotube differentiation involved in skeletal muscle regeneration +negative regulation of myotube differentiationpositive regulation of myotube differentiationregulation of myotube differentiation +negative regulation of skeletal muscle cell differentiation +positive regulation of skeletal muscle cell differentiation +regulation of skeletal muscle cell differentiation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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