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Gene Ontology Browser
Term Detail
GO term:myotube differentiation
GO id:GO:0014902
Definition:The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amuscle cell differentiation
                                                        is-astriated muscle cell differentiation
                                                                is-acardiac muscle cell differentiation +
                                                                is-amyotube differentiation [GO:0014902] (116 genes, 161 annotations)
                                                                        part-ofmyoblast fusion +
                                                                        part-ofmyotube cell development +
                                                                        is-amyotube differentiation involved in skeletal muscle regeneration +
                                                                        negatively-regulatesnegative regulation of myotube differentiation +
                                                                        positively-regulatespositive regulation of myotube differentiation +
                                                                        regulatesregulation of myotube differentiation +
                                                                        is-askeletal muscle fiber differentiation +
                                                                negatively-regulatesnegative regulation of striated muscle cell differentiation +
                                                                positively-regulatespositive regulation of striated muscle cell differentiation +
                                                                regulatesregulation of striated muscle cell differentiation +
                                                                part-ofstriated muscle cell development +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-aanatomical structure development
                                is-amuscle structure development
                                        part-ofmuscle cell differentiation
                                                is-astriated muscle cell differentiation
                                                        is-acardiac muscle cell differentiation +
                                                        is-amyotube differentiation [GO:0014902] (116 genes, 161 annotations)
                                                                part-ofmyoblast fusion +
                                                                part-ofmyotube cell development +
                                                                is-amyotube differentiation involved in skeletal muscle regeneration +
                                                                negatively-regulatesnegative regulation of myotube differentiation +
                                                                positively-regulatespositive regulation of myotube differentiation +
                                                                regulatesregulation of myotube differentiation +
                                                                is-askeletal muscle fiber differentiation +
                                                        negatively-regulatesnegative regulation of striated muscle cell differentiation +
                                                        positively-regulatespositive regulation of striated muscle cell differentiation +
                                                        regulatesregulation of striated muscle cell differentiation +
                                                        part-ofstriated muscle cell development +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amuscle cell differentiation
                                                        is-astriated muscle cell differentiation
                                                                is-acardiac muscle cell differentiation +
                                                                is-amyotube differentiation [GO:0014902] (116 genes, 161 annotations)
                                                                        part-ofmyoblast fusion +
                                                                        part-ofmyotube cell development +
                                                                        is-amyotube differentiation involved in skeletal muscle regeneration +
                                                                        negatively-regulatesnegative regulation of myotube differentiation +
                                                                        positively-regulatespositive regulation of myotube differentiation +
                                                                        regulatesregulation of myotube differentiation +
                                                                        is-askeletal muscle fiber differentiation +
                                                                negatively-regulatesnegative regulation of striated muscle cell differentiation +
                                                                positively-regulatespositive regulation of striated muscle cell differentiation +
                                                                regulatesregulation of striated muscle cell differentiation +
                                                                part-ofstriated muscle cell development +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-amuscle structure development
                                        part-ofmuscle cell differentiation
                                                is-astriated muscle cell differentiation
                                                        is-acardiac muscle cell differentiation +
                                                        is-amyotube differentiation [GO:0014902] (116 genes, 161 annotations)
                                                                part-ofmyoblast fusion +
                                                                part-ofmyotube cell development +
                                                                is-amyotube differentiation involved in skeletal muscle regeneration +
                                                                negatively-regulatesnegative regulation of myotube differentiation +
                                                                positively-regulatespositive regulation of myotube differentiation +
                                                                regulatesregulation of myotube differentiation +
                                                                is-askeletal muscle fiber differentiation +
                                                        negatively-regulatesnegative regulation of striated muscle cell differentiation +
                                                        positively-regulatespositive regulation of striated muscle cell differentiation +
                                                        regulatesregulation of striated muscle cell differentiation +
                                                        part-ofstriated muscle cell development +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amuscle cell differentiation
                                                        is-astriated muscle cell differentiation
                                                                is-acardiac muscle cell differentiation +
                                                                is-amyotube differentiation [GO:0014902] (116 genes, 161 annotations)
                                                                        part-ofmyoblast fusion +
                                                                        part-ofmyotube cell development +
                                                                        is-amyotube differentiation involved in skeletal muscle regeneration +
                                                                        negatively-regulatesnegative regulation of myotube differentiation +
                                                                        positively-regulatespositive regulation of myotube differentiation +
                                                                        regulatesregulation of myotube differentiation +
                                                                        is-askeletal muscle fiber differentiation +
                                                                negatively-regulatesnegative regulation of striated muscle cell differentiation +
                                                                positively-regulatespositive regulation of striated muscle cell differentiation +
                                                                regulatesregulation of striated muscle cell differentiation +
                                                                part-ofstriated muscle cell development +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-acell differentiation
                                                is-amuscle cell differentiation
                                                        is-astriated muscle cell differentiation
                                                                is-acardiac muscle cell differentiation +
                                                                is-amyotube differentiation [GO:0014902] (116 genes, 161 annotations)
                                                                        part-ofmyoblast fusion +
                                                                        part-ofmyotube cell development +
                                                                        is-amyotube differentiation involved in skeletal muscle regeneration +
                                                                        negatively-regulatesnegative regulation of myotube differentiation +
                                                                        positively-regulatespositive regulation of myotube differentiation +
                                                                        regulatesregulation of myotube differentiation +
                                                                        is-askeletal muscle fiber differentiation +
                                                                negatively-regulatesnegative regulation of striated muscle cell differentiation +
                                                                positively-regulatespositive regulation of striated muscle cell differentiation +
                                                                regulatesregulation of striated muscle cell differentiation +
                                                                part-ofstriated muscle cell development +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-amuscle structure development
                                        part-ofmuscle cell differentiation
                                                is-astriated muscle cell differentiation
                                                        is-acardiac muscle cell differentiation +
                                                        is-amyotube differentiation [GO:0014902] (116 genes, 161 annotations)
                                                                part-ofmyoblast fusion +
                                                                part-ofmyotube cell development +
                                                                is-amyotube differentiation involved in skeletal muscle regeneration +
                                                                negatively-regulatesnegative regulation of myotube differentiation +
                                                                positively-regulatespositive regulation of myotube differentiation +
                                                                regulatesregulation of myotube differentiation +
                                                                is-askeletal muscle fiber differentiation +
                                                        negatively-regulatesnegative regulation of striated muscle cell differentiation +
                                                        positively-regulatespositive regulation of striated muscle cell differentiation +
                                                        regulatesregulation of striated muscle cell differentiation +
                                                        part-ofstriated muscle cell development +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory