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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Notch1
notch 1
MGI:97363
182 phenotypes from 24 alleles in 40 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Albtm1(cre/ERT2)Mtz/Alb+
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6
increased cholangiocarcinoma incidence J:192740
Cpa3tm3(icre)Hrr/Cpa3+
Notch1tm1Agt/Notch1tm1Agt
involves: 129 * C57BL/6
abnormal B cell differentiation J:143731
abnormal B cell morphology J:143731
abnormal T cell receptor beta chain V(D)J recombination J:143731
decreased double-negative T cell number J:143731
decreased double-positive T cell number J:143731
increased single-positive T cell number J:143731
thymus hypoplasia J:143731
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA
decreased B cell number J:167000
enlarged spleen J:167000
increased leukemia incidence J:167000
increased leukocyte cell number J:167000
premature death J:167000
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * ICR
abnormal endocrine pancreas morphology J:86975
abnormal exocrine pancreas morphology J:86975
abnormal pancreas development J:86975
decreased pancreatic alpha cell number J:86975
decreased pancreatic beta cell number J:86975
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA
abnormal pancreas development J:169830
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Pdx1-cre/Esr1*)35.10Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA
abnormal pancreas development J:86975
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/Esr1*)1Dam/0
involves: 129S4/SvJae * C57BL/6 * CBA
absent pancreatic alpha cells J:86975
embryonic lethality during organogenesis, complete penetrance J:86975
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Col1a1-cre)1Kry/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
abnormal bone marrow cavity morphology J:233131
abnormal skeleton morphology J:233131
abnormal trabecular bone morphology J:233131
decreased body weight J:233131
decreased bone trabecular spacing J:233131
increased bone mass J:233131
increased bone trabecula number J:233131
increased trabecular bone thickness J:233131
increased trabecular bone volume J:233131
kinked tail J:233131
osteosclerosis J:233131
postnatal growth retardation J:233131
thick neurocranium J:233131
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre)C1Able/0
involves: 129S4/SvJaeSor
abnormal pancreas development J:190530
abnormal pancreatic duct morphology J:190530
absent pancreatic islets J:190530
decreased body weight J:190530
normal endocrine/exocrine gland phenotype J:190530
hyperglycemia J:190530
postnatal lethality, complete penetrance J:190530
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S4/SvJaeSor * 129S6/SvEvTac
normal vision/eye phenotype J:118372
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129S4/SvJaeSor * C57BL/6J
abnormal renal tubule morphology J:185844
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Hes1tm1(cre/ERT2)Lcm/Hes1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
abnormal pancreas development J:169830
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ
abnormal white fat cell differentation J:237232
absent epididymal fat pad J:237232
decreased susceptibility to diet-induced obesity J:237232
hepatic steatosis J:237232
hyperglycemia J:237232
increased circulating insulin level J:237232
increased liposarcoma incidence J:237232
increased liver weight J:237232
insulin resistance J:237232
lipodystrophy J:237232
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Wt1-cre)#Jbeb/0
involves: 129S4/SvJaeSor
abnormal epicardium morphology J:178290
hemopericardium J:178290
lethality throughout fetal growth and development J:178290
thin myocardium compact layer J:178290
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurod1-cre)1Able/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
abnormal pancreas morphology J:190530
abnormal pancreatic islet morphology J:190530
normal homeostasis/metabolism phenotype J:190530
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/ERT2)1Able/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
normal endocrine/exocrine gland phenotype J:190530
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sortm1(Notch1)Dam
involves: 129S4/SvJae * C57BL/6
no abnormal phenotype detected J:86975
Mesp1tm2(cre)Ysa/Mesp1+
Tg(CAG-cat,-Notch1)1Ysa/0
involves: C3H * C57BL/6 * CBA
abnormal atrioventricular cushion morphology J:108444
abnormal heart development J:108444
abnormal heart shape J:108444
abnormal heart ventricle morphology J:108444
abnormal interventricular septum morphology J:108444
abnormal myocardial fiber morphology J:108444
abnormal myocardium layer morphology J:108444
abnormal sarcomere morphology J:108444
abnormal trabecula carnea morphology J:108444
decreased heart right ventricle size J:108444
dilated heart left ventricle J:108444
embryonic lethality during organogenesis, complete penetrance J:108444
enlarged heart J:139209
Notch1sot/Notch1sot
involves: 129S1/Sv * C57BL/6 * FVB/NJ
abnormal nervous system development J:171522
abnormal trigeminal ganglion morphology J:171522
abnormal vascular development J:171522
decreased embryo size J:171522
embryonic lethality during organogenesis, complete penetrance J:171522
small pharyngeal arch J:171522
Notch1tm1.1(cre/ERT2)Sat/Notch1+
C57BL/6-Notch1tm1.1(cre/ERT2)Sat
no abnormal phenotype detected J:179632
Notch1tm1.1(cre/ERT2)Sat/Notch1tm1.1(cre/ERT2)Sat
C57BL/6-Notch1tm1.1(cre/ERT2)Sat
embryonic lethality J:179632
Notch1tm1Agt/Notch1tm1Agt
involves: 129
no abnormal phenotype detected J:55400
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA
abnormal B cell differentiation J:125373
abnormal T cell differentiation J:55400, J:125373
abnormal thymus cell ratio J:55400, J:143472
abnormal thymus morphology J:55400
decreased body weight J:55400
decreased CD4-positive, alpha beta T cell number J:55400
decreased CD8-positive, alpha-beta T cell number J:55400
decreased double-negative T cell number J:55400
decreased double-positive T cell number J:55400
decreased single-positive T cell number J:55400
decreased thymocyte number J:55400
normal hematopoietic system phenotype J:98129
increased immature B cell number J:143472
postnatal growth retardation J:55400
premature death J:55400
small thymus J:55400
Notch1tm1Agt/Notch1tm1Agt
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL
abnormal angiogenesis J:100449
abnormal anterior cardinal vein morphology J:100449
abnormal intersomitic vessel morphology J:100449
abnormal placental labyrinth vasculature morphology J:100449
abnormal somite development J:100449
abnormal vascular branching morphogenesis J:100449
abnormal vitelline vascular remodeling J:100449
delayed heart looping J:100449
embryonic growth arrest J:100449
embryonic growth retardation J:100449
embryonic lethality during organogenesis, complete penetrance J:100449
hemopericardium J:100449
hemorrhage J:100449
incomplete embryo turning J:100449
increased apoptosis J:100449
neural tube degeneration J:100449
pericardial effusion J:100449
thin myocardium J:100449
Notch1tm1Agt/Notch1tm1Agt
Tg(Tek-cre)12Flv/0
involves: 129 * C3H * C57BL/6
abnormal angiogenesis J:100449
abnormal anterior cardinal vein morphology J:100449
abnormal intersomitic vessel morphology J:100449
abnormal placental labyrinth vasculature morphology J:100449
abnormal somite development J:100449
abnormal vascular branching morphogenesis J:100449
abnormal vitelline vascular remodeling J:100449
delayed heart looping J:100449
embryonic growth arrest J:100449
embryonic growth retardation J:100449
embryonic lethality during organogenesis, complete penetrance J:100449
hemopericardium J:100449
hemorrhage J:100449
incomplete embryo turning J:100449
increased apoptosis J:100449
neural tube degeneration J:100449
pericardial effusion J:100449
thin myocardium J:100449
Notch1tm1Agt/Notch1tm1Agt
Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2
diluted coat color J:116658
Notch1tm1Agt/Notch1tm1Agt
Tg(Wt1-cre)#Jbeb/0
involves: 129
abnormal coronary vessel morphology J:178290
absent coronary vessels J:178290
embryonic lethality during organogenesis J:178290
hemopericardium J:178290
hemorrhage J:178290
myocardium hypoplasia J:178290
thin myocardium compact layer J:178290
Notch1tm1b(EUCOMM)Hmgu/Notch1+
C57BL/6N-Notch1tm1b(EUCOMM)Hmgu/H
abnormal vertebrae morphology J:211773
Notch1tm1b(EUCOMM)Hmgu/Notch1tm1b(EUCOMM)Hmgu
C57BL/6N-Notch1tm1b(EUCOMM)Hmgu/H
preweaning lethality, complete penetrance J:211773
Notch1tm1Con/Notch1+
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal aortic valve morphology J:187551
calcified aortic valve J:187551
normal cardiovascular system phenotype J:187551
thick aortic valve cusps J:187551
Notch1tm1Con/Notch1tm1Con
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
abnormal cell death J:25248
abnormal left-right axis symmetry of the somites J:25248
abnormal rostral-caudal axis patterning J:25248
abnormal somite development J:25248, J:62882
abnormal somite size J:25248
decreased embryo size J:25248
delayed somite formation J:25248
distended pericardium J:25248, J:62882
embryonic growth arrest J:25248, J:62882
embryonic lethality during organogenesis, complete penetrance J:25248
kinked neural tube J:62882
notochord degeneration J:25248
Notch1tm1Con/Notch1tm1Con
involves: 129S1/Sv * 129X1/SvJ
abnormal myocardium layer morphology J:119151
disorganized myocardium J:119151
trabecula carnea hypoplasia J:119151
Notch1tm1Con/Notch1tm1Grid
Tg(Pax2-cre)1Akg/0
involves: 129S1/Sv * 129X1/SvJ
abnormal vascular development J:119907
embryonic lethality during organogenesis, complete penetrance J:119907
internal hemorrhage J:119907
normal renal/urinary system phenotype J:119907
Notch1tm1Grid/Notch1+
involves: 129S1/Sv * C57BL/6
abnormal retinal blood vessel morphology J:227333
increased cochlear outer hair cell number J:62727
Notch1tm1Grid/Notch1tm1Grid
involves: 129S1/Sv * C57BL/6
abnormal dorsal aorta morphology J:62571
abnormal placenta vasculature J:62571
absent vitelline blood vessels J:62571
decreased angiogenesis J:62571
embryonic growth retardation J:17509
embryonic lethality during organogenesis, complete penetrance J:17509
pale yolk sac J:62571
Notch1tm1Grid/Notch1tm2Rko
Foxg1tm1(cre)Skm/Foxg1+
involves: 129 * C57BL/6J * Swiss Webster
decreased organ of Corti supporting cell number J:132241
increased cochlear inner hair cell number J:132241
Notch1tm1Pst/Notch1tm1Pst
involves: 129/Sv * C57BL/6 * SJL
abnormal embryonic tissue morphology J:112097
embryonic growth retardation J:112097
embryonic lethality during organogenesis, complete penetrance J:112097
Notch1tm1Rko/Notch1tm1Rko
involves: 129X1/SvJ
abnormal rostral-caudal axis patterning J:62882
abnormal somite development J:62882
absent vitelline blood vessels J:62882
distended pericardium J:62882
embryonic growth arrest J:62882
embryonic growth retardation J:62882
embryonic lethality, complete penetrance J:62882
kinked neural tube J:62882
Notch1tm2.1Pst/Notch1tm2.1Pst
B6.Cg-Notch1tm2.1Pst
embryonic growth retardation J:131563
embryonic lethality during organogenesis, complete penetrance J:131563
Notch1tm2.1Rko/Notch1+
Not Specified
abnormal vertebrae morphology J:186213
Notch1tm2Agt/Notch1tm2Agt
involves: 129
abnormal artery morphology J:89444
abnormal cardiac epithelial to mesenchymal transition J:133699
Notch1tm2Agt/Notch1tm2Agt
involves: 129/Sv * C57BL/6
embryonic lethality during organogenesis, complete penetrance J:55400
Notch1tm2Pst/Notch1tm2.1Pst
involves: 129/Sv * C57BL/6 * SJL
abnormal embryonic neuroepithelium morphology J:131563
abnormal heart development J:131563
abnormal vasculogenesis J:131563
anemia J:131563
decreased embryo size J:131563
embryonic growth retardation J:131563
embryonic lethality during organogenesis, complete penetrance J:131563
Notch1tm2Pst/Notch1tm2Pst
B6.Cg-Notch1tm2Pst
abnormal T cell differentiation J:131563
decreased double-negative T cell number J:131563
decreased T cell number J:131563
decreased thymocyte number J:131563
increased T cell apoptosis J:131563
postnatal growth retardation J:131563
Notch1tm2Rko/Notch1tm2Rko
H2afvTg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6 * CBA
normal craniofacial phenotype J:181120
perinatal lethality, complete penetrance J:181120
Notch1tm2Rko/Notch1tm2Rko
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N
alopecia J:194073
decreased conjunctiva goblet cell number J:194073
dry eyes J:194073
lacrimal gland degeneration J:194073
Meibomian gland degeneration J:194073
Notch1tm2Rko/Notch1tm2Rko
Tg(Msx2-cre)5Rem/0
Not Specified
abnormal hair follicle morphology J:94517
abnormal hair growth J:94517
abnormal hair shaft morphology J:94517
disorganized inner root sheath cells J:94517
short hair J:94517
small sebaceous gland J:94517
waved hair J:94517
Notch1tm2Rko/Notch1tm2Rko
Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6J * SJL
abnormal apoptosis J:90392
increased neuron number J:90392
Notch1tm2Rko/Notch1tm3(cre)Rko
involves: 129X1/SvJ * C57BL/6
abnormal cornea morphology J:171829
abnormal hepatic cord morphology J:171829
abnormal liver lobule morphology J:171829
abnormal liver morphology J:171829
abnormal liver parenchyma morphology J:171829
abnormal spleen morphology J:171829
corneal deposits J:171829
corneal vascularization J:171829
enlarged liver sinusoidal spaces J:171829
enlarged spleen J:171829
extramedullary hematopoiesis J:171829
hemoperitoneum J:171829
increased angiogenesis J:171829
increased hemangioma incidence J:171829
liver inflammation J:171829
pale liver J:171829
premature death J:171829
Notch1tm2Rko/Notch1tm4(cre)Rko
involves: 129X1/SvJ * C57BL/6
abnormal vitelline vasculature morphology J:171829
embryonic lethality during organogenesis, complete penetrance J:171829
Notch1tm3(cre)Rko/Notch1tm3(cre)Rko
involves: 129X1/SvJ * C57BL/6J * SJL
embryonic lethality during organogenesis, complete penetrance J:119910
Notch1tm5(cre/ERT2)Rko/Notch1tm5(cre/ERT2)Rko
involves: C57BL/6NTac
embryonic lethality during organogenesis J:101977
Tg(LckNotch1)9Erob/?
involves: C57BL/6 * CBA/J
abnormal CD8-positive, alpha-beta T cell differentiation J:93005
abnormal thymus cell ratio J:93005
decreased CD4-positive, alpha beta T cell number J:93005
increased CD8-positive, alpha-beta T cell number J:93005
increased T cell derived lymphoma incidence J:93005
Tg(Notch1)1Anc/0
Not Specified
curly vibrissae J:65042
focal hair loss J:65042
short vibrissae J:65042
waved hair J:65042
Tg(Notch1)A3Rko/0
involves: FVB/N
no abnormal phenotype detected J:62217
Tg(Notch1)A4Rko/0
involves: FVB/N
no abnormal phenotype detected J:62217
Tg(Notch1)A5Rko/0
involves: FVB/N
alopecia J:62217
curly vibrissae J:62217
decreased curvature of zigzag hairs J:62217
deformed nails J:62217
waved hair J:62217
Tg(Notch1)A7Rko/0
involves: FVB/N
alopecia J:62217
curly vibrissae J:62217
decreased curvature of zigzag hairs J:62217
deformed nails J:62217
waved hair J:62217

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory