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Cdkn2b
Gene Detail
Symbol

Name
ID
Cdkn2b
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
MGI:104737
Synonyms
MTS2, p15, p15INK4b
Feature Type
protein coding gene
Genetic Map
Chromosome 4
42.15 cM, cytoband C3-C6
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr4:89306289-89311032 bp, - strand
From NCBI annotation of GRCm38

  4744 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2b

Human
homologs
Human Homolog CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
NCBI Gene ID 1030
neXtProt AC  NX_P42772
Human Synonyms  CDK4I, INK4B, MTS2, P15, p15INK4b, TP15
Human Chr (Location)  9p21; chr9:22002903-22009313 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Cdkn2b (2)
 
Animals homozygous for a mutation in this gene exhibit increased tumor incidence, lymphoid hyperplasia, and extramedullary hematopoiesis.
 
Interactions
Cdkn2b interacts with 94 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell cycle, cell cycle arrest, ...
Component cytoplasm, nucleoplasm, ...
Function cyclin-dependent protein serine/threonine kinase inhibitor activity, protein kinase binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (52)    Tissues (45)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
Northern blot 12
RT-PCR 11
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(8) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000073802 (Evidence)
Entrez Gene12579 (Evidence)
UniGene423094
DFCITC1581896
DoTSDT.40172039
NIA Mouse Gene IndexU355440
PDB1D9S
Consensus CDS ProjectCCDS18351.1
International Mouse Knockout Project StatusCdkn2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12579 NCBI Gene Model | MGI Sequence Detail 4744 C57BL/6J ±  kb
transcript NM_007670 RefSeq | MGI Sequence Detail 1393 C57BL/6 
polypeptide P55271 UniProt | EBI | MGI Sequence Detail 130 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000000093 cyclin-dependent kinase 4 inhibitor B
Graphical View of Protein Domain Structure
References
(Earliest) J:20317 Hannon GJ, et al., p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest [see comments]. Nature. 1994 Sep 15;371(6494):257-61
(Latest) J:212177 Collins C, et al., C/EBPalpha is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9899-904
All references(95)
Other
accession IDs
MGD-MRK-27100, MGI:2140526

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory