Cdkn2b
Gene Detail

Symbol Name ID

Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) MGI:104737

Synonyms

MTS2, p15, p15INK4b

Feature Type

protein coding gene

Genetic Map

Chromosome 4

42.15 cM, cytoband C3-C6
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr4:89306289-89311032 bp, - strand From NCBI annotation of GRCm38   4744 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2b

Human homologs

Human Homolog		CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
NCBI Gene ID		1030
neXtProt AC		NX_P42772
Human Synonyms		CDK4I, INK4B, MTS2, P15, p15INK4b, TP15
Human Chr (Location)		9p21; chr9:22002902-22009312 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Animals homozygous for a mutation in this gene exhibit increased tumor incidence, lymphoid hyperplasia, and extramedullary hematopoiesis.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	cytoplasm, nucleus
Function	cyclin-dependent protein serine/threonine kinase inhibitor activity, kinase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (50)    Tissues (44)    Images (10)
Theiler Stages: 10, 15, 17, 18, 19, 23, 25, 28

Assay Type	Results
RNA in situ	29
Northern blot	12
RT-PCR	9

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(8) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000073802 (Evidence)
Entrez Gene	12579 (Evidence)
UniGene	423094
DFCI	TC1581896
DoTS	DT.40172039
NIA Mouse Gene Index	U355440
PDB	1D9S
Consensus CDS Project	CCDS18351.1
International Mouse Knockout Project Status	Cdkn2b

Sequences

Length	Strain/Species
genomic	12579	NCBI Gene Model | MGI Sequence Detail	4744	C57BL/6J
transcript	NM_007670	RefSeq | MGI Sequence Detail	1393	C57BL/6
polypeptide	P55271	UniProt | EBI | MGI Sequence Detail	130	Not Applicable

All sequences(20) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
Protein Ontology	PR:000000093	cyclin-dependent kinase 4 inhibitor B

Graphical View of Protein Domain Structure

References

(Earliest) J:20317 Hannon GJ, et al., p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest [see comments]. Nature. 1994 Sep 15;371(6494):257-61
(Latest) J:192707 He A, et al., Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 3;110(3):406-15
All references(82)

Other accession IDs

MGD-MRK-27100, MGI:2140526