Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to be located in mitochondrion; nuclear lumen; and senescence-associated heterochromatin focus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with nuclear body. Is expressed in several structures, including central nervous system; eye; genitourinary system; immune system; and liver. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to several human genes including CDKN2B (cyclin dependent kinase inhibitor 2B).

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Gene Ontology Evidence Code Abbreviations:

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