Phenotypes Associated with This Genotype

Genotype
MGI:4354207

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(Tyr-BRAF*V600E)470Fgh/0
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:151455 )

• survival is less than in Tg(Tyr-BRAF*V600E)470Fgh mice dying within days or weeks of developing hydrocephalus and paralysis

neoplasm

increased melanoma incidence ( J:151455 )

• mice develop increased incidence of melanomas with reduced latency and decreased lifespan compared to mice with Tg(Tyr-BRAF*V600E)470Fgh

• mice exhibit metastasis to the lung and lymph nodes

behavior/neurological

paralysis ( J:151455 )

nervous system

hydrocephaly ( J:151455 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:151455