Phenotypes Associated with This Genotype

Genotype
MGI:3768649

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(Tyr-NRAS*Q61K)1Bee/?
• Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased cutaneous melanoma incidence ( J:98545 )

• 17 of 18 mice develop cutaneous melanomas within 6 months of birth

• melanomas present as black and frequently ulcerated nodules that are found in the trunk (in 81% of mice), upper and lower extremities (in 22% of mice), and head and neck (in 39% of mice)

• acral melanomas and melanomas of the genitalia are present in a few mice

• melanomas are predominantly melanotic and epitheloid containing numerous macrophages and are vascularized

• in some tumors, atypical melanocytes are found un the surface or adnexal epithelium

• in some mice tumors are present within a rather hyperplastic epidermis or at the epidermal/dermal junction of hair follicle

• only 10% to 50% of tumor cells express nestin indicating that melanomas are comprised of at least two subpopulations

increased metastatic potential ( J:98545 )

• melanomas metastasize to the liver and lung in 36% of mice

immune system

enlarged lymph nodes ( J:98545 )

• 64% of tumor-bearing mice exhibit enlarged lymph nodes

integument

increased cutaneous melanoma incidence ( J:98545 )

• 17 of 18 mice develop cutaneous melanomas within 6 months of birth

• melanomas present as black and frequently ulcerated nodules that are found in the trunk (in 81% of mice), upper and lower extremities (in 22% of mice), and head and neck (in 39% of mice)

• acral melanomas and melanomas of the genitalia are present in a few mice

• melanomas are predominantly melanotic and epitheloid containing numerous macrophages and are vascularized

• in some tumors, atypical melanocytes are found un the surface or adnexal epithelium

• in some mice tumors are present within a rather hyperplastic epidermis or at the epidermal/dermal junction of hair follicle

• only 10% to 50% of tumor cells express nestin indicating that melanomas are comprised of at least two subpopulations

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:98545