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Phenotypes Associated with This Genotype
Genotype
MGI:3768653
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2a+
Tg(Tyr-NRAS*Q61K)1Bee/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (3 available); any Cdkn2a mutation (59 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased cutaneous melanoma incidence ( J:98545 )
• 15 of 18 mice develop cutaneous melanomas within 12 months of birth

integument
increased cutaneous melanoma incidence ( J:98545 )
• 15 of 18 mice develop cutaneous melanomas within 12 months of birth

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
skin melanoma DOID:8923 J:98545

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory