Mouse Genome Informatics
cn1
    Braftm2Cpri/Braf+
Tg(CMV-cre)1Cgn/0

B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• only 70% of mice survive to adulthood with some mice lost after weaning

cardiovascular system

immune system
• in most mice
• 4-fold in most mice
• one mouse exhibits hyperplasia of lymphoid tissue at 73 weeks

tumorigenesis
• predisposition in aged mice
• one mouse exhibits small intestinal adenoma at 79 weeks

vision/eye
• including cataracts and watery eyes in some mice
• in some mice

craniofacial
• facial dysmorphia
• in some mice

growth/size/body
• facial dysmorphia
• in some mice

muscle

nervous system

reproductive system
• one mouse exhibits hyperplasia of the smooth muscles of the uterus at 23 weeks
• in some mice

digestive/alimentary system
• predisposition in aged mice

hematopoietic system
• in most mice
• 4-fold in most mice

integument
• predisposition in aged mice

homeostasis/metabolism


Mouse Genome Informatics
cn2
    Calcrtm1Rda/Calcrtm1Rda
Tg(CMV-cre)1Cgn/0

B6.Cg-Calcrtm1Rda Tg(CMV-cre)1Cgn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• levels are increased to 40 and 34 pg/ml in male and female mice from basal levels of less than 5 pg/ml in controls
• mice have higher rises in serum calcium level when administered calcitrol (active form of vitamin D) than controls
• rise in serum calcium is 44% higher in males and 21% higher in females

immune system
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin

limbs/digits/tail
• femur length in male mice is 4% shorter than controls at 6, 12, and 24 weeks of age

skeleton
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin
• femur length in male mice is 4% shorter than controls at 6, 12, and 24 weeks of age
• the trabecular structures in female mice are more rod-like than plate-like
• trabecular separation in the vertebrae of male mice is increased compared to controls
• trabecular bone formation is increased 20-40% in the femur of male mice
• trabecular bone volume in vertebrae of female mice is reduced by 6% at 6 weeks of age
• however, female mice do not have vertebrae trabecular bone loss as the age as controls do leading to 27% increase in bone volume by 24 weeks of age
• also, connectivity density is doubled in trabecular bone
• in female femur, trabecular thickness is decreased by 11% compared to controls

hematopoietic system
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin


Mouse Genome Informatics
cn3
    Errfi1tm3.1Gvw/Errfi1tm3.1Gvw
Tg(CMV-cre)1Cgn/0

involves: 129 * 129S4/SvJaeSor * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most die by 6 months of age

skeleton
• develop an osteoarthritis like phenotype in multiple synovial joints including the knee, ankle and temporal-mandibular joint
• in knee joints of 3.6 months old animals
• osteophytes in knee joints of 3 months to 1 year old animals
• ankles show extensive changes including swelling, stiffness, osteophytes
• in ankles

immune system
• develop an osteoarthritis like phenotype in multiple synovial joints including the knee, ankle and temporal-mandibular joint


Mouse Genome Informatics
cn4
    Prnptm1Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?

involves: 129P2/OlaHsd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that in wild-type mice (J:92302)


Mouse Genome Informatics
cn5
    Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?

involves: 129P2/OlaHsd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that heterozygous Prnptm2Edin mice


Mouse Genome Informatics
cn6
    Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?

involves: 129P2/OlaHsd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• no signs of TSE disease are seen 520 days postinfection an increased incubation time compared to wild-type or or mutants without cre recombination


Mouse Genome Informatics
cn7
    Prnptm2Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?

involves: 129P2/OlaHsd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• an increased incubation time for TSE strain ME7 compared to wild-type mice or mutants without cre recombination is seen


Mouse Genome Informatics
cn8
    Braftm1Cpri/Braf+
Tg(CMV-cre)1Cgn/0

involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• embryos with high levels of Cre mediated recombination are in the process of being resorbed at E7.5, while those with more mosaic recombination survived to later ages but still die before birth


Mouse Genome Informatics
cn9
    Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1+
Tg(CMV-cre)1Cgn/0

involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• authors state the they observe all phenotypic features of heterozygous Ctnnb1tm1(Nfkbia)Rsu mutants in these mice, however no data is presented in J:71744

immune system
• keratoconjunctivits sicca

vision/eye
• keratoconjunctivits sicca

growth/size/body
• about 50-70% of wild-type

endocrine/exocrine glands
• atrophy of Harderian glands

hearing/vestibular/ear

digestive/alimentary system
• reduction in the number of intestinal goblet cells
• the epithelial structure of the small intestine is loosened

cardiovascular system

craniofacial

hematopoietic system

liver/biliary system
• in embryos only

reproductive system

skeleton

limbs/digits/tail

behavior/neurological

integument
• patchy alopecia in older mice

cellular
• in embryos only

Mouse Models of Human Disease
OMIM IDRef(s)
Otitis Media, Susceptibility to 166760 J:71744


Mouse Genome Informatics
cn10
    Ehmt1tm1.2Tara/Ehmt1+
Tg(CMV-cre)1Cgn/0

involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• decrease in distance traveled and vertical activity in a new environment
• in a new environment
• in a new environment


Mouse Genome Informatics
cn11
    9630033F20Riktm1.1Khv/9630033F20Riktm1.1Khv
Tg(CMV-cre)1Cgn/0

involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
digestive/alimentary system

immune system


Mouse Genome Informatics
cn12
    Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(CMV-cre)1Cgn/0

involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging

cardiovascular system

respiratory system

homeostasis/metabolism


Mouse Genome Informatics
cn13
    Pygo1tm1Ssp/Pygo1tm1Ssp
Tg(CMV-cre)1Cgn/?

involves: 129S1/Sv * 129X1/SvJ * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mice are viable and have no obvious phenotype


Mouse Genome Informatics
cn14
    Pygo2tm1.1Ssp/Pygo2tm1.1Ssp
Tg(CMV-cre)1Cgn/?

involves: 129S1/Sv * 129X1/SvJ * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most mice die neonatally

vision/eye
• in all day-of-birth mice lenses were small or absent
• in all day-of-birth mice lenses were small or absent
• optic cups are misshapen with abnormal retinal folds and excess mesenchyme cells
• however, retinal differentiation and retinal pigment epithelium are grossly normal

renal/urinary system
• mild kidney development defects

growth/size/body
• mice are smaller late gestation


Mouse Genome Informatics
cn15
    Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Tg(CMV-cre)1Cgn/?

involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice are born but with rare exceptions die shortly afterwards

renal/urinary system
• at high penetrance
• at E18.5, mesenchyme surrounding the ureteric buds is thickened 30% and ureteric tips are dilated and misshaped
• however, nephrogenesis is normal

vision/eye
• at high penetrance

growth/size/body
• at low penetrance
• at high penetrance
• at high penetrance

nervous system
• at low penetrance

craniofacial
• at low penetrance

digestive/alimentary system
• at low penetrance


Mouse Genome Informatics
cn16
    Pax3tm1Mrc/Pax3+
Tg(CMV-cre)1Cgn/?

involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
craniofacial
• the frontal bone is absent
• dysgenesis of the nasal bone is seen

muscle

skeleton
• the frontal bone is absent
• dysgenesis of the nasal bone is seen
• midline fusion of the sternum is incomplete
• multiple rib fusions are seen
• multiple vertebral fusions are seen

vision/eye
• the optic placode is present at E8.75 but completely degenerated by E12.5

nervous system
• disorganized, ectopic midbrain hyperplasia of neuroectodermal precursors is seen by E12.5
• forebrain hypoplasia is visible at E9.75
• the cortex is disorganized
• olfactory lobe agenesis is seen
• the dorsal root ganglia is hyperplastic

growth/size/body


Mouse Genome Informatics
cn17
    Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?

involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• double mutants develop breathing difficulties after 7 - 8 months of age
• frequent embryonic lethality; however, a significant number of double mutants survive

tumorigenesis
• a large spectrum of multifocal lesions are seen in the lung including; small patches of bronchiolo-alveolar hyperplasias to large bronchiolo-alveolar adenomas that compress adjacent lung structures and appear to derive from type II pneumocytes
• large bronchiolo-alveolar adenocarcinomas that compress adjacent lung structures and appear to derive from type II pneumocytes
• histiocytic sarcoma and other sarcomas seen in 2 out of 20 and 3 out of 20 double mutants, respectively
• anal papillomas seen in 3 out of 20 double mutants

cellular
• MEFs expressing the oncogenic protein do not undergo proliferative senescence and proliferate continuously as immortal cells

respiratory system
• double mutants develop breathing difficulties after 7 - 8 months of age


Mouse Genome Informatics
cn18
    Cdk4tm1.1Bbd/Cdk4+
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?

involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• latency to develop lung adenomas is significantly shorter compared to double mutants wild-type for Cdk4; however development of tumors characteristic of Cdk4tm1.1Bbd mutant mice is not accelerated
• histiocytic sarcoma and other sarcomas are seen
• anal papillomas are seen

digestive/alimentary system
• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells

endocrine/exocrine glands
• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells


Mouse Genome Informatics
cn19
    Mmp13tm1Werb/Mmp13tm1Werb
Tg(CMV-cre)1Cgn/0

involves: 129S2/SvPas * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
integument
N
• epidermal architecture and dermal composition are normal and show no differences in efficiency of re-epithelialization, inflammatory response, granulation tissue formation, angiogenesis, and restoration of basement membrane, indicating that skin homeostasis and tissue remodeling processes are normal (J:104953)


Mouse Genome Informatics
cn20
    Pax4tm1Pgr/Pax4tm1.1Aman
Tg(CMV-cre)1Cgn/0

involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• some mice die at birth after a cross to transgenic mice expressing CMV-cre
• some mice die within a few days of birth after a cross to transgenic mice expressing CMV-cre

endocrine/exocrine glands
• after a cross to transgenic mice expressing CMV-cre
• after a cross to transgenic mice expressing CMV-cre
• after a cross to transgenic mice expressing CMV-cre


Mouse Genome Informatics
cn21
    Tg(CMV-cre)1Cgn/0
Trp53tm2Att/Trp53+

involves: 129S4/SvJae * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no viable adults are found and no postnatal lethality is detected suggesting mice die in the prenatal period


Mouse Genome Informatics
cn22
    Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(CMV-cre)1Cgn/Y

involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging


Mouse Genome Informatics
cn23
    Adamts4tm1Lex/Adamts4tm1Lex
Tg(CMV-cre)1Cgn/0

involves: 129S5/SvEvBrd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• viable, fertile, and phenotypically normal


Mouse Genome Informatics
cn24
    Adamts5tm1Lex/Adamts5tm1Lex
Tg(CMV-cre)1Cgn/0

involves: 129S5/SvEvBrd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
skeleton
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal

immune system
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal


Mouse Genome Informatics
cn25
    Adamts5tm1Lex/Adamts5tm1.1Lex
Tg(CMV-cre)1Cgn/?

involves: 129S5/SvEvBrd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
N
• mice are fertile (J:105138)

skeleton
• aggrecan loss (as measured by loss of toiludine blue staining in the tibiofemoral joint) is significantly less (1.15+/-0.15 mean score compared to 1.94+/-0.13 in wild-type joints)
• tibial cartilage erosion is seen in 1 of 13 joints as compared to 5 of 14 wild-type joints


Mouse Genome Informatics
cn26
    Adamts4tm1Lex/Adamts4tm1.1Lex
Tg(CMV-cre)1Cgn/?

involves: 129S5/SvEvBrd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
skeleton
N
• cartilage formation is normal (J:105138)


Mouse Genome Informatics
cn27
    Myh10tm5Rsad/Myh10tm5Rsad
Tg(CMV-cre)1Cgn/0

involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice show reduced ability to maintain balance on rotarod; performance depends on rate of rotation, such that at low speeds, mice show no deficiency

nervous system
• small number of Purkinje cells have abnormal orientation deviating from normal orientation where cell bodies are perpendicular to the surface of the cerebellar cortex
• almost all cells show a marked decrease in branches and dendritic spines compared to wild-type
• cell bodies of some Purkinje cells are dissociated from the cerebellar Purkinje cell layer and ectopically located in molecular layer


Mouse Genome Informatics
cn28
    Med12tm1.1Hsch/Med12+
Tg(CMV-cre)1Cgn/0

involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• fewer female embryos from a cross of hemizygous males and homozygous cre expressing females at E13.5 (J:166045)
• only one female in 16 live births (J:166045)

embryogenesis
• neural tube defects of variable severity at E11.5 in females (J:166045)
• in 30% of E12.5 mice (J:166045)

nervous system
• neural tube defects of variable severity at E11.5 in females (J:166045)
• in 30% of E12.5 mice (J:166045)
• exencephaly and spina bifida in 63% of mice over E12.5 (J:166045)

skeleton
• some calvarial bones missing (J:166045)
• splayed spina processes (J:166045)

limbs/digits/tail
• in 18 of 22 mice (J:166045)

craniofacial
• some calvarial bones missing (J:166045)


Mouse Genome Informatics
cn29
    Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(CMV-cre)1Cgn/0

involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system

nervous system
• Pomc+ neurons

growth/size/body

adipose tissue
• increased visceral fat mass weight

homeostasis/metabolism
• in ovariectomized mice (J:199640)


Mouse Genome Informatics
cn30
    Artm1Jdz/Y
Tg(CMV-cre)1Cgn/0

involves: 129X1/SvJ * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• testis weights at 3 weeks are significantly lower (3.5 mg) than control males (24.9-27 mg) (J:157337)

reproductive system
• testis weights at 3 weeks are significantly lower (3.5 mg) than control males (24.9-27 mg) (J:157337)


Mouse Genome Informatics
cn31
    Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sortm1(EYFP)Cos
Tg(CMV-cre)1Cgn/0

involves: 129X1/SvJ * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• analysis of hematopoietic cells demonstrates reliable detection of YFP and RFP in same cells as well as in different cells


Mouse Genome Informatics
cn32
    Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(CMV-cre)1Cgn/0

involves: BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mice are born at expected Mendelian rations and do not exhibit any gross abnormalities


Mouse Genome Informatics
cn33
    Glp1rtm1.1Stof/Glp1rtm1.1Stof
Tg(CMV-cre)1Cgn/0

involves: BALB/c * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• after exendin-4 treatment, mice fail to exhibit a hypophagic response unlike control mice

homeostasis/metabolism
• sham operated mice tended to be more glucose-intolerant than control mice

growth/size/body
N
• after vertical sleeve gastrectomy, mice exhibit normal weight changes (J:206563)


Mouse Genome Informatics
cn34
    Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0

involves: BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• fewer than expected mice with this genotype are found

hematopoietic system
• the fraction of B and T cells expressing the recombined allele decreases during differentiation and maturation


Mouse Genome Informatics
cn35
    Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0

involves: BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• slightly fewer than expected mice with this genotype are found

hematopoietic system
• the fraction of B and T cells expressing the recombined allele decreases during differentiation and maturation


Mouse Genome Informatics
cn36
    Pax7tm1.1Thbr/Pax7tm1.1Thbr
Tg(CMV-cre)1Cgn/0

involves: BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
muscle
• authors state that mice phenocopy Pax7tm2Pgr homozygotes


Mouse Genome Informatics
cn37
    Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)1Roer/0

involves: BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• only about 25% of mice survive to adulthood
• surviving mice show signs of spontaneous regression of the hyperproliferative dysregulation of erythropoiesis
• rapid lethality in about 75% of neonatal mice

digestive/alimentary system
• survivors develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

hematopoietic system
• mice appear to die of hyperproliferative dysregulation of erythropoiesis
• dramatic dysregulation of hematopoiesis characterized by excessive numbers of nucleated cells in the peripheral blood
• increase in nucleated cells is primarily the result of a population of small blastic cells with sparse cytoplasm
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• increase in the number of nuclear shadows in blood smears indicates the presence of cells with increased mechanical fragility

liver/biliary system
• most of the liver parenchyma is replaced with Ter119+ cells

immune system
• survivors develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn


Mouse Genome Informatics
cn38
    Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)3Roer/0

involves: BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• only about 25% of mice survive to adulthood
• surviving mice show signs of spontaneous regression of the hyperproliferative dysregulation of erythropoiesis
• rapid lethality in about 75% of neonatal mice

hematopoietic system
• mice appear to die of hyperproliferative dysregulation of erythropoiesis
• dramatic dysregulation of hematopoiesis characterized by excessive numbers of nucleated cells in the peripheral blood
• increase in nucleated cells is primarily the result of a population of small blastic cells with sparse cytoplasm
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)3Roer and Tg(Mx1-cre)1Cgn
• increase in the number of nuclear shadows in blood smears indicates the presence of cells with increased mechanical fragility

liver/biliary system
• most of the liver parenchyma is replaced with Ter119+ cells

immune system
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)3Roer and Tg(Mx1-cre)1Cgn


Mouse Genome Informatics
cn39
    Pmltm1(PML/RARA)Ley/Pml+
Tg(CMV-cre)1Cgn/0

involves: BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no mice are produced


Mouse Genome Informatics
cn40
    Padi4tm1.1Kmow/Padi4tm1.1Kmow
Tg(CMV-cre)1Cgn/0

involves: BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• bone marrow-derived mast cells exhibit normal ATP-stimulated citrullination (J:190651)


Mouse Genome Informatics
cn41
    Wlstm1.1Arte/Wlstm1.1Arte
Tg(CMV-cre)1Cgn/?

involves: BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die mid-gestation


Mouse Genome Informatics
cx42
    Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Tg(CMV-cre)1Cgn/?

involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• mice are normal


Mouse Genome Informatics
cx43
    Tinf2tm2.1Tdl/Tinf2+
Tg(CMV-cre)1Cgn/0

involves: BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size/body
• mice weigh slightly less than wild type littermates at weaning and 6 months of age

mortality/aging
• mutants are born at a lower than expected frequency (35%)