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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnf
tumor necrosis factor
MGI:104798
101 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
B2mtm1Jae/B2mtm1Jae
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J 		small intestinal inflammation J:108572
Ccl25tm1.1Mal/Ccl25tm1.1Mal
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		abnormal alpha-beta intraepithelial T cell morphology J:136667
abnormal T cell subpopulation ratio J:136667
decreased gamma-delta intraepithelial T cell number J:136667
intestinal inflammation J:136667
Ccr9tm1.1Mal/Ccr9tm1.1Mal
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		abnormal alpha-beta intraepithelial T cell morphology J:136667
abnormal T cell subpopulation ratio J:136667
decreased gamma-delta intraepithelial T cell number J:136667
intestinal inflammation J:136667
Cd4tm1Mak/Cd4tm1Mak
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J 		premature death J:108572
small intestinal inflammation J:108572
Cd44tm1Hbg/Cd44+
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		ileum inflammation J:145626
Cd44tm1Hbg/Cd44tm1Hbg
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		normal digestive/alimentary phenotype J:145626
normal immune system phenotype J:145626
Cyp2g1tm1(rtTA)Lane/Cyp2g1+
Tg(SFTPC-rtTA,tetO-Tnf)320-1Gwho/0
involves: 129 * C57BL/6 * SJL 		abnormal olfactory epithelium morphology J:157842
abnormal olfactory sensory neuron morphology J:157842
anosmia J:157842
decreased cell proliferation J:157842
impaired olfaction J:157842
increased macrophage cell number J:157842
rhinitis J:157842
Faddtm1Mpa/Faddtm1Mpa
Tnftm1Gkl/Tnftm1Gkl
Tg(Vil1-cre)997Gum/0
B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil1-cre)997Gum 		cecum inflammation J:175865
colitis J:175865
decreased Paneth cell number J:175865
Ifngtm1Ts/Ifngtm1Ts
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J 		small intestinal inflammation J:108572
Ighmtm1Cgn/Ighmtm1Cgn
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J 		small intestinal inflammation J:108572
Il12btm1Jm/Il12btm1Jm
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S1/Sv * C57BL/6J 		small intestinal inflammation J:108572
Irak1tm1Jth/Irak1tm1Jth
Tg(Myh6-Tnf)1Brgi/?
involves: 129/Sv * C57BL/6J * SJL 		abnormal heart morphology J:84829
normal mortality/aging J:84829
myocardial fiber degeneration J:84829
myocarditis J:84829
Irak1tm1Jth/Y
Tg(Myh6-Tnf)1Brgi/?
involves: 129/Sv * C57BL/6J * SJL 		abnormal heart morphology J:84829
normal mortality/aging J:84829
myocardial fiber degeneration J:84829
myocarditis J:84829
Itgb7tm1Cgn/Itgb7tm1Cgn
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * C57BL/6 		abnormal inflammatory response J:136667
arthritis J:136667
Krt8tm1Rgo/Krt8tm1Rgo
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N 		normal mortality/aging J:121811
prenatal lethality, incomplete penetrance J:121811
Map3k8tm1Pnt/Map3k8tm1Pnt
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		increased CD8-positive, alpha-beta T cell number J:108572
increased single-positive T cell number J:108572
small intestinal inflammation J:108572
Mapk9tm1Flv/Mapk9tm1Flv
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		normal immune system phenotype J:108572
increased apoptosis J:108572
small intestinal inflammation J:108572
Mapk11tm1Jsca/Mapk11tm1Jsca
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		arthritis J:107771
ileum inflammation J:107771
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		decreased apoptosis J:108572
granulomatous inflammation J:108572
normal immune system phenotype J:108572
premature death J:108572
small intestinal inflammation J:108572
Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6J 		abnormal retina morphology J:175587
retina photoreceptor degeneration J:175587
thin retina inner nuclear layer J:175587
thin retina outer nuclear layer J:175587
Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae 		neonatal lethality, complete penetrance J:91366
prenatal lethality, incomplete penetrance J:91366
thin epidermis J:91366
Nfkbiztm1Aki/Nfkbiztm1Aki
Tnftm1Sek/Tnftm1Sek
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj 		conjunctivitis J:194832
dermatitis J:194832
eyelid edema J:194832
Nos2tm1Mrl/Nos2tm1Mrl
Tg(Myh6-Tnf)1.6Amf/?
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		abnormal atrioventricular node conduction J:109732
abnormal cardiac muscle contractility J:109732
abnormal heart electrocardiography waveform feature J:109732
abnormal heart ventricle pressure J:109732
abnormal myocardial fiber physiology J:109732
decreased cardiac muscle contractility J:109732
decreased heart rate J:109732
irregular heartbeat J:109732
Rag1tm1Mom/Rag1tm1Mom
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 		rheumatoid arthritis J:54056
small intestinal inflammation J:54056
Reltm1Grd/Reltm1Grd
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae 		abnormal cell cycle J:91366
abnormal epidermal layer morphology J:91366
abnormal epidermis stratum basale morphology J:91366
abnormal hair follicle placode formation J:91366
abnormal keratinocyte morphology J:91366
decreased cell proliferation J:91366
decreased embryo size J:91366
decreased hair follicle number J:91366
neonatal lethality, complete penetrance J:91366
thin epidermis J:91366
underdeveloped hair follicles J:91366
Relatm1Bal/Relatm1Bal
Tnftm1Ljo/Tnftm1Ljo
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		abnormal nervous system physiology J:124444
Relatm1Yuo/Relatm1Yuo
Tnftm1Ljo/Tnftm1Ljo
involves: 129S/SvEv * 129S1/Sv 		abnormal myogenesis J:135692
decreased skeletal muscle fiber diameter J:135692
increased skeletal muscle fiber number J:135692
Rigitm1Aki/Rigitm1Aki
Tnftm1Sek/Tnftm1Sek
involves: C57BL/6 * CBA 		postnatal lethality J:100539
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J 		abnormal osteoclast differentiation J:117880
normal immune system phenotype J:117880
normal skeleton phenotype J:117880
Stat3tm2Aki/Stat3tm2Aki
Tnftm1Sek/Tnftm1Sek
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		colitis J:83280
increased interferon-gamma secretion J:83280
increased interleukin-6 secretion J:83280
increased interleukin-12b secretion J:83280
Tbk1tm1Aki/Tbk1tm1Aki
Tnftm1Sek/Tnftm1Sek
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal cytotoxic T cell physiology J:132662
decreased cytotoxic T cell cytolysis J:132662
decreased IgG1 level J:132662
decreased IgG2a level J:132662
decreased IgG level J:132662
decreased interferon-gamma secretion J:132662
normal mortality/aging J:132662
Tcrdtm1Mom/Tcrdtm1Mom
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		small intestinal inflammation J:108572
Tg(Ins2-CD80)3B7Flv/0
Tg(Ins2-Tnf)17Flv/0
involves: C57BL/6 * CBA/Ca 		abnormal cytokine secretion J:93555
increased circulating glucose level J:93555
increased susceptibility to autoimmune diabetes J:93555
Tg(Ins2-CD86)12B70Flv/0
Tg(Ins2-Tnf)17Flv/0
involves: C57BL/6 * CBA/Ca 		abnormal cytokine secretion J:93555
increased circulating glucose level J:93555
increased susceptibility to autoimmune diabetes J:93555
Tg(Tnf)6074Gkl/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal oligodendrocyte apoptosis J:106592
CNS inflammation J:106592
demyelination J:106592
Timp3tm1Rkho/Timp3tm1Rkho
Tnftm1Gkl/Tnftm1Gkl
involves: 129 * 129S/SvEv * C57BL/6 		decreased ventricle muscle contractility J:112033
dilated heart left ventricle J:112033
increased neutrophil cell number J:112033
TnfBpsm1/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 		increased circulating tumor necrosis factor level J:226052
normal skeleton phenotype J:226052
TnfBpsm1/TnfBpsm1
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 		increased circulating tumor necrosis factor level J:226052
normal skeleton phenotype J:226052
Tnfem5Boui/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1a+
involves: 129S2/SvPas * C57BL/6 		abnormal lung morphology J:306876
arthritis J:306876
cardiovalvulitis J:306876
colitis J:306876
premature death J:306876
preweaning lethality, incomplete penetrance J:306876
Tnftm1Gkl/Tnftm1Gkl
Tnfaip3tm1Ama/Tnfaip3tm1Ama
involves: 129S/SvEv * C57BL/6J 		abnormal cytokine secretion J:92694
abnormal inflammatory response J:92694
cachexia J:92694
premature death J:92694
Tnftm1Gkl/Tnftm1Gkl
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129S/SvEv * C57BL/6 		normal immune system phenotype J:92470
Tnftm1Gkl/Tnftm1Gkl
Zfp36tm1Pjb/Zfp36tm1Pjb
involves: 129S/SvEv * C57BL/6 		abnormal vasodilation J:214114
oxidative stress J:214114
Tnftm1Ljo/Tnf+
Tnip1tm1.1Ama/Tnip1tm1.1Ama
involves: 129S1/Sv * C57BL/6J 		perinatal lethality, incomplete penetrance J:145539
Tnftm1Ljo/Tnftm1Ljo
Tnip1tm1.1Ama/Tnip1tm1.1Ama
involves: 129S1/Sv * C57BL/6J 		normal mortality/aging J:145539
Tnftm2Gkl/Tnf+
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		rheumatoid arthritis J:54056
small intestinal inflammation J:54056
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA 		normal cardiovascular system phenotype J:264147
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/?
involves: 129S/SvEv * C57BL/6 * CBA 		arthritis J:131930
small intestinal inflammation J:131930
Tnftm2Gkl/Tnf+
Tnfrsf1btm1.1Gkl/Tnfrsf1btm1.1Gkl
Tg(Col6a1-cre)1Gkl/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA 		abnormal cell adhesion J:264147
abnormal cell physiology J:264147
abnormal fibroblast physiology J:264147
abnormal wound healing J:264147
normal cardiovascular system phenotype J:264147
increased circulating tumor necrosis factor level J:264147
increased tumor necrosis factor secretion J:264147
joint inflammation J:264147
Tnftm2Gkl/Tnf+
Tnfrsf1btm1.2Gkl/Tnfrsf1btm1.2Gkl
involves: 129S/SvEv * C57BL/6 * C57BL/6J 		abnormal cell adhesion J:264147
abnormal cell physiology J:264147
abnormal fibroblast physiology J:264147
abnormal wound healing J:264147
aortic valve inflammation J:264147
aortic valve stenosis J:264147
arthritis J:264147
cardiac fibrosis J:264147
increased circulating tumor necrosis factor level J:264147
increased tumor necrosis factor secretion J:264147
Tnftm2Gkl/Tnftm2Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		increased circulating tumor necrosis factor level J:54056
increased tumor necrosis factor secretion J:54056
Tnftm3Gkl/Tnftm3Gkl
Zfp36tm1Pjb/Zfp36tm1Pjb
involves: 129S/SvEv * C57BL/6 		normal immune system phenotype J:114740
myeloid hyperplasia J:114740
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04/16/2024
MGI 6.23 		The Jackson Laboratory