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Targeted Allele Detail
Symbol: Timp3tm1Rkho
Name: tissue inhibitor of metalloproteinase 3; targeted mutation 1, Rama Khokha
MGI ID: MGI:2387409
Synonyms: timp-3-, Timp-3-null
Gene: Timp3  Location: Chr10:86136276-86185369 bp, + strand  Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
Alliance: Timp3tm1Rkho page
Germline Transmission:  Earliest citation of germline transmission: J:71609
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of part of exon 1 (just upstream of the translation initiation codon) to part of exon 2 (after the conserved VIRAK codons) with a neomycin resistance cassette in the reverse orientation. Northern blot of lung, kidney, and heart RNA and RT-PCR analysis did not detect gene expression in homozygous mutants. Reverse zymographic analysis of kidney extracts did not detect protein activity in homozygous animals. (J:71609)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 46 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Timp3tm1Rkho
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Timp3 Mutation:  12 strains or lines available
Original:  J:71609 Leco KJ, et al., Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). J Clin Invest. 2001 Sep;108(6):817-29
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory