Tnfrsf1b^tm1.2Gkl
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1b^tm1.2Gkl
• Name: tumor necrosis factor receptor superfamily, member 1b; targeted mutation 1.2, George Kollias
• MGI ID: MGI:6195556
• Synonyms: Tnfrsf1b^D
• Gene: Tnfrsf1b Location: Chr4:144940033-144973440 bp, - strand Genetic Position: Chr4, 78.17 cM
• Alliance: Tnfrsf1b^tm1.2Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264147
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and a FRT-flanked neo cassette was inserted upstream of the first loxP site via homologous recombination. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2, resulting in a frame shift mutation. (J:264147)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1b Mutation: 37 strains or lines available

References

• Original: J:264147 Sakkou M, et al., Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis. JCI Insight. 2018 Apr 5;3(7)
• All: 1 reference(s)