Tnfrsf1a^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^tm1Mak
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Tak Mak
• MGI ID: MGI:1857261
• Synonyms: p55^-, Pfeffer Tnfrsf1a^-, TNF-alphaRI^-, TNFR-, TNF-R1-, TNFR1-, TNFR1/p55^-, TNFRp55-, Tnfrsf1a-, Tnfrsf1^atm1Mak
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4753
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted at position 535 of the coding sequence. A radioligand binding assay demonstrated that no functional protein was present on the cell surface of splenocytes derived from homozygous mice. (J:4753, J:29283)

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tnfrsf1a^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 47 strains or lines available

References

• Original: J:4753 Pfeffer K, et al., Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 1993 May 7;73(3):457-67
• All: 322 reference(s)