Cyp2g1^{tm1(rtTA)Lane}
Targeted Allele Detail

Summary

• Symbol: Cyp2g1^{tm1(rtTA)Lane}
• Name: cytochrome P450, family 2, subfamily g, polypeptide 1; targeted mutation 1, Andrew P Lane
• MGI ID: MGI:4437871
• Synonyms: Cyp2g1-rtTA
• Gene: Cyp2g1 Location: Chr7:26508352-26520622 bp, + strand Genetic Position: Chr7, 15.5 cM, cytoband A3
• Alliance: Cyp2g1^{tm1(rtTA)Lane} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: A targeting vector containing an rtTA cassette and a floxed neo cassette was inserted at 32 bp upstream of the transcription start site, putting the transactivator protein under the control of the olfactory-specific endogenous promoter. Induction with doxycycline resulted in robust expression that was restricted to the olfactory mucosa and inducer-dependent. (J:157842)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2g1 Mutation: 30 strains or lines available

References

• Original: J:157842 Lane AP, et al., A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. J Neurosci. 2010 Feb 10;30(6):2324-9
• All: 4 reference(s)