Tg(Ins2-Tnf)17Flv
Transgene Detail

Summary

• Symbol: Tg(Ins2-Tnf)17Flv
• Name: transgene insertion 17, Richard Flavell
• MGI ID: MGI:3764663
• Synonyms: RIP-TNFalpha
• Transgene: Tg(Ins2-Tnf)17Flv Location: unknown
• Alliance: Tg(Ins2-Tnf)17Flv page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Tnf)17Flv expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnf (MGI:104798)

• Tg(Ins2-Tnf)17Flv expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The transgene construct contained the murine Tnf-alpha gene driven by the rat insulin 2 promoter (RIP). Founder mice carried the transgene with copy number ranging from 2-20 per genome. Line 17 was used for further study. Transcripts of the transgene were detected by Northern blot only in the pancreas of the mice. (J:91820)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:91820 Picarella DE, et al., Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. J Immunol. 1993 May 1;150(9):4136-50
• All: 4 reference(s)