Rel^tm1Grd
Targeted Allele Detail

Summary

• Symbol: Rel^tm1Grd
• Name: reticuloendotheliosis oncogene; targeted mutation 1, Steve Gerondakis
• MGI ID: MGI:2179622
• Synonyms: c-rel-, cRel-
• Gene: Rel Location: Chr11:23686847-23720969 bp, - strand Genetic Position: Chr11, 14.36 cM
• Alliance: Rel^tm1Grd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28435
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a genomic fragment containing exons 4-9, which encode regions required for DNA binding, dimerization, nuclear transport and transcriptional trans-acrivation. (J:28435)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rel Mutation: 44 strains or lines available

References

• Original: J:28435 Kontgen F, et al., Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 1995 Aug 15;9(16):1965-77
• All: 59 reference(s)