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Tg(Myh6-Tnf)1Brgi
Transgene Detail
Summary
Symbol: Tg(Myh6-Tnf)1Brgi
Name: transgene insertion 1, Brett Giroir
MGI ID: MGI:3586566
Transgene: Tg(Myh6-Tnf)1Brgi  Location: unknown  
Alliance: Tg(Myh6-Tnf)1Brgi page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Tnf)1Brgi expresses 1 gene
 
Mutation detailsThe tumor necrosis factor alpha gene was placed under the control of the mouse alpha cardiac myosin heavy chain promoter. Six founder mice were produced of which, four produced an abnormal phenotype. Only two of the phenotypically abnormal founders reproduce. Lineage one contained approximately 20 copies of the transgene. (J:100006)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:100006 Bryant D, et al., Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation. 1998 Apr 14;97(14):1375-81
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/14/2023
MGI 6.22
The Jackson Laboratory