Phenotypes associated with this allele

• Allele Symbol: Kit⁺
• Allele Name: wild type
• Allele ID: MGI:1857588
• Summary: 113 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kit^W-44J/Kit^+	B6.C3-Kit^W-44J/J	MGI:3055517
ht2	Kit^W-19H/Kit^+	B6.Cg-Kit^W-19H/EiJ	MGI:3778825
ht3	Kit^M1Hmgu/Kit^+	C3HeB/FeJ-Kit^M1Hmgu	MGI:5436145
ht4	Kit^Mhdasco1/Kit^+	C3HeB/FeJ-Kit^Mhdasco1	MGI:3716899
ht5	Kit^Mhdasco5/Kit^+	C3HeB/FeJ-Kit^Mhdasco5	MGI:3716900
ht6	Kit^Mhdasow3/Kit^+	C3HeB/FeJ-Kit^Mhdasow3	MGI:3716901
ht7	Kit^W-1Bao/Kit^+	C57BL/6J-Kit^W-1Bao	MGI:3033449
ht8	Kit^W-20J/Kit^+	C57BL/6J-Kit^W-20J/J	MGI:3813594
ht9	Kit^W-2Bao/Kit^+	C57BL/6J-Kit^W-2Bao	MGI:3033440
ht10	Kit^W-2Btlr/Kit^+	C57BL/6J-Kit^W-2Btlr	MGI:3779023
ht11	Kit^W-34J/Kit^+	C57BL/6J-Kit^W-34J/J	MGI:3813668
ht12	Kit^W-35J/Kit^+	C57BL/6J-Kit^W-35J/J	MGI:3813670
ht13	Kit^W-37J/Kit^+	C57BL/6J-Kit^W-37J/J	MGI:3813673
ht14	Kit^W-39J/Kit^+	C57BL/6J-Kit^W-39J/J	MGI:3813677
ht15	Kit^W-3Bao/Kit^+	C57BL/6J-Kit^W-3Bao	MGI:3033447
ht16	Kit^W-40J/Kit^+	C57BL/6J-Kit^W-40J/J	MGI:3813679
ht17	Kit^W-41J/Kit^+	C57BL/6J-Kit^W-41J/J	MGI:3813681
ht18	Kit^W-42J/Kit^+	C57BL/6J-Kit^W-42J/J	MGI:2167486
ht19	Kit^W-43J/Kit^+	C57BL/6J-Kit^W-43J/J	MGI:3813683
ht20	Kit^W-55J/Kit^+	C57BL/6J-Kit^W-55J/J	MGI:3843802
ht21	Kit^W-85J/Kit^+	C57BL/6J-Kit^W-85J/GrsrJ	MGI:5578559
ht22	Kit^Wads/Kit^+	C57BL/6J-Kit^Wads	MGI:3573948
ht23	Kit^W-Bs/Kit^+	C57BL/6J-Kit^W-Bs	MGI:2677344
ht24	Kit^W-Btlr/Kit^+	C57BL/6J-Kit^W-Btlr	MGI:3778371
ht25	Kit^W-ei/Kit^+	C57BL-Kit^W-ei	MGI:3029935
ht26	Kit^W-rio/Kit^+	DBA/2-Kit^W-rio	MGI:3813877
ht27	Kit^tm1Bpr/Kit^+	either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)	MGI:3603339
ht28	Kit^W/Kit^+	FL/1Re-Kit^W/J	MGI:4849374
ht29	Kit^W-ct/Kit^+	involves: 101/H * C3H/HeH	MGI:3813733
ht30	Kit^W-19H/Kit^+	involves: 101/H * C3H/HeH	MGI:3036839
ht31	Kit^W-28H/Kit^+	involves: 101/H * C3H/HeH	MGI:3813600
ht32	Kit^W-29H/Kit^+	involves: 101/H * C3H/HeH	MGI:3813604
ht33	Kit^W-e/Kit^+	involves: 101/H * C3H/HeH	MGI:3843928
ht34	Kit^W-sh/Kit^+	involves: 101/H * C3H/HeH * CBA	MGI:3029932
ht35	Kit^d18/Kit^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3576857
ht36	Kit^tm2Ber/Kit^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3045953
ht37	Kit^tm1Ber/Kit^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3045958
ht38	Kit^tm1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J	MGI:2178068
ht39	Kit^tm5.1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:5510144
ht40	Kit^tm4.1Bsm/Kit^+	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:5442707
ht41	Kit^tm1Alf/Kit^+	involves: 129S2/SvPas	MGI:3770811
ht42	Kit^W-84J/Kit^+	involves: 129S2/SvPas * C57BL/6J	MGI:5578538
ht43	Kit^tm1Shta/Kit^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3773053
ht44	Kit^tm1Rosay/Kit^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4940018
ht45	Kit^tm2Bsm/Kit^+	involves: 129X1/SvJ * C57BL/6J	MGI:2663997
ht46	Kit^W-39H/Kit^+	involves: BALB/cCrl * C3H/HeNCrl	MGI:2175085
ht47	Kit^W-s/Kit^+	involves: BRS	MGI:3813891
ht48	Kit^W-j/Kit^+	involves: C3H	MGI:3813809
ht49	Kit^W-18J/Kit^+	involves: C3HeB/Fe * C57BL/6	MGI:3813593
ht50	Kit^Whc1/Kit^+	involves: C3HeB/Fe * C57BL/6	MGI:3760793
ht51	Kit^W-82J/Kit^+	involves: C3HeB/FeLe	MGI:2176285
ht52	Kit^W-x/Kit^+	involves: C3H/HeJ	MGI:3813831
ht53	Kit^W-2Btlr/Kit^+	involves: C3H/HeN * C57BL/6	MGI:3779025
ht54	Kit^W-f/Kit^+	involves: C3H/HePas	MGI:3055548
ht55	Kit^W-v/Kit^+	involves: C57BL	MGI:5000282
ht56	Kit^Ssm/Kit^+	involves: C57BL/10 * Non-inbred	MGI:3029324
ht57	Kit^W-v/Kit^+	involves: C57BL/6	MGI:2387551
ht58	Kit^W-Jic/Kit^+	involves: C57BL/6	MGI:3813816
ht59	Kit^W-37J/Kit^+	involves: C57BL/6 * C57BL/6J	MGI:3813820
ht60	Kit^W-42J/Kit^+	involves: C57BL/6 * C57BL/6J * WB	MGI:3813818
ht61	Kit^W-rio/Kit^+	involves: C57BL/6 * DBA/2	MGI:3813878
ht62	Kit^W-51J/Kit^+	involves: C57BL/6J	MGI:3813709
ht63	Kit^W-70J/Kit^+	involves: C57BL/6J	MGI:3813842
ht64	Kit^W-59J/Kit^+	involves: C57BL/6J	MGI:3813717
ht65	Kit^W-49J/Kit^+	involves: C57BL/6J	MGI:3813706
ht66	Kit^W-3Bao/Kit^+	involves: C57BL/6J	MGI:4822200
ht67	Kit^W-2Bao/Kit^+	involves: C57BL/6J	MGI:4822201
ht68	Kit^Wads/Kit^+	involves: C57BL/6J	MGI:4822203
ht69	Kit^W-38J/Kit^+	involves: C57BL/6J	MGI:3813675
ht70	Kit^Wps/Kit^+	involves: C57BL/6J * CBA/CaJ	MGI:5523968
ht71	Kit^W-v/Kit^+	involves: C57BL * C57BL/6	MGI:3813828
ht72	Kit^W-v/Kit^+	involves: C57BL * DBA	MGI:4431037
ht73	Kit^W-b/Kit^+	involves: C57BL/St	MGI:3813731
ht74	Kit^W-57J/Kit^+	involves: C58/J	MGI:3029836
ht75	Kit^W-45J/Kit^+	involves: DBA/2J	MGI:3813705
ht76	Kit^W-73J/Kit^+	involves: DBA/2J	MGI:3813861
ht77	Kit^W-pw/Kit^+	involves: STOCK Prop1^df Myo5a^d Bmp5^se	MGI:3053007
ht78	Kit^W-bd/Kit^+	involves: STOCK Rw Fgf5^go Vps33a^bf	MGI:3770430
ht79	Kit^W-n/Kit^+	involves: WB	MGI:3813823
ht80	Kit^W-a/Kit^+	involves: Z	MGI:3813730
ht81	Kit^W-31H/Kit^+	Not Specified	MGI:5306973
ht82	Kit^W-17J/Kit^+	Not Specified	MGI:3813590
ht83	Kit^W-24J/Kit^+	Not Specified	MGI:3813595
ht84	Kit^W-v/Kit^+	Not Specified	MGI:3842474
ht85	Kit^W-38H/Kit^+	Not Specified	MGI:5306978
ht86	Kit^W-n/Kit^+	Not Specified	MGI:3055567
ht87	Kit^W-80J/Kit^+	Not Specified	MGI:3813721
ht88	Kit^W/Kit^+	Not Specified	MGI:2175088
ht89	Kit^W-32H/Kit^+	Not Specified	MGI:5306976
cn90	Kit^tm1(cre/ERT2)Dsa/Kit^+ Prkg1^tm2Naw/Prkg1^tm2Naw	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5545743
cn91	Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor^+ Kit^tm1(cre/ERT2)Dsa/Kit^+	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	MGI:5545742
cx92	f/f Kit^W/Kit^+	FL/1Re-Kit^W/J	MGI:4849372
cx93	f/f^+ Kit^W/Kit^+	FL/1Re-Kit^W/J	MGI:4849373
cx94	Kit^W-v/Kit^+ Rw/Rw^+	involves: 101/H * C3H/HeH * C57BL	MGI:4431075
cx95	Kit^W-v/Kit^+ Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv * C57BL	MGI:2652596
cx96	Kit^W-v/Kit^+ Snai2^tm2Grid/Snai2^+	involves: 129S1/Sv * C57BL	MGI:2652598
cx97	Mitf^tm5.1Arnh/Mitf^tm5.1Arnh Kit^tm1Alf/Kit^+	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N	MGI:5316641
cx98	Mitf^tm7.1Arnh/Mitf^tm7.1Arnh Kit^tm1Alf/Kit^+	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N	MGI:5316642
cx99	Adamts20^bt-2H/Adamts20^bt-2H Kit^tm1Alf/Kit^+	involves: 129S2/SvPas * C57BL/6	MGI:3783653
cx100	Kit^tm1Rosay/Kit^+ Lep^ob/Lep^ob	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4940020
cx101	Kit^W-v/Kit^+ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778813
cx102	Kit^W-19H/Kit^+ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778792
cx103	Kit^W-e/Kit^+ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3778814
cx104	Kit^W-42J/Kit^+ X/Sry^AKR/J	involves: AKR/J * C57BL/6J	MGI:3716808
cx105	Kit^W-27H/Kit^+ X/Sry^AKR/J	involves: AKR/J * C57BL/6J * CBA/H	MGI:3778815
cx106	Kit^W-v/Kit^+ Tg(Mt1-RET)304Ina/0	involves: BALB/c * C57BL/6	MGI:5297719
cx107	Kit^W-v/Kit^+ Rps19^Mhdadsk3/Rps19^+	involves: C3HeB/FeJ * C57BL/6J	MGI:6260000
cx108	Kit^W/Kit^+ Tg(PGK1-KITLG*220)441Daw/0	involves: C3H/HeJ	MGI:3817635
cx109	Kit^W-v/Kit^+ Ph/Ph^+	involves: C57BL	MGI:4431077
cx110	Fbn1^Tsk/Fbn1^+ Kit^W/Kit^+	involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ	MGI:3619906
cx111	Kit^W-42J/Kit^+ X/Sry^POS-TIR	involves: C57BL/6J	MGI:3716810
cx112	a/a Kit^W-2J/Kit^+	involves: C57BL/6J	MGI:3813609
cx113	Kit^Wps/Kit^+ Pax3^Sp-1Wli/Pax3^+	involves: C57BL/6J * CBA/CaJ	MGI:5523974

Genotype
MGI:3055517

ht1

• Allelic Composition: Kit^W-44J/Kit⁺
• Genetic Background: B6.C3-Kit^W-44J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

white spotting ( J:6571 )

• white feet and tail tip

belly spot ( J:6571 )

• very small spot to only a few hairs

hematopoietic system

hematopoietic system phenotype ( J:6571 )

N • no hematopoietic system abnormalities detected

integument

white spotting ( J:6571 )

• white feet and tail tip

belly spot ( J:6571 )

• very small spot to only a few hairs

Genotype
MGI:3778825

ht2

• Allelic Composition: Kit^W-19H/Kit⁺
• Genetic Background: B6.Cg-Kit^W-19H/EiJ

reproductive system

reproductive system phenotype ( J:133405 )

N • ovaries function and transplant fine

constricted vagina orifice ( J:133405 )

♀ • Background Sensitivity: approximately 60% of females have clsoed vaginas

Genotype
MGI:5436145

ht3

• Allelic Composition: Kit^M1Hmgu/Kit⁺
• Genetic Background: C3HeB/FeJ-Kit^M1Hmgu

hematopoietic system

increased erythrocyte cell number ( J:186868 )

increased hematocrit ( J:186868 )

decreased mean corpuscular hemoglobin ( J:186868 )

decreased mean corpuscular volume ( J:186868 )

Genotype
MGI:3716899

ht4

• Allelic Composition: Kit^Mhdasco1/Kit⁺
• Genetic Background: C3HeB/FeJ-Kit^Mhdasco1

pigmentation

abnormal coat/hair pigmentation ( J:86685 )

• tiny head spot; bright belly

integument

abnormal coat/hair pigmentation ( J:86685 )

• tiny head spot; bright belly

Genotype
MGI:3716900

ht5

• Allelic Composition: Kit^Mhdasco5/Kit⁺
• Genetic Background: C3HeB/FeJ-Kit^Mhdasco5

pigmentation

abnormal coat/hair pigmentation ( J:86685 )

• complex coat colour variation

integument

abnormal coat/hair pigmentation ( J:86685 )

• complex coat colour variation

Genotype
MGI:3716901

ht6

• Allelic Composition: Kit^Mhdasow3/Kit⁺
• Genetic Background: C3HeB/FeJ-Kit^Mhdasow3

pigmentation

head blaze ( J:86685 )

belly spot ( J:86685 )

integument

head blaze ( J:86685 )

belly spot ( J:86685 )

Genotype
MGI:3033449

ht7

• Allelic Composition: Kit^W-1Bao/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-1Bao

pigmentation

variable body spotting ( J:88137 )

• extensive white piebald appearance

variable depigmentation ( J:88137 )

• coincident with white coat spotting

reproductive system

male infertility ( J:88137 )

♂ • many, but not all males, are sterile

reduced male fertility ( J:88137 )

♂ • average litter size is half that of background strain

integument

variable body spotting ( J:88137 )

• extensive white piebald appearance

variable depigmentation ( J:88137 )

• coincident with white coat spotting

Genotype
MGI:3813594

ht8

• Allelic Composition: Kit^W-20J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-20J/J

integument

white spotting ( J:6571 )

pigmentation

white spotting ( J:6571 )

Genotype
MGI:3033440

ht9

• Allelic Composition: Kit^W-2Bao/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-2Bao

pigmentation

variable body spotting ( J:88137 )

• extensive white trunk band and variable spotting elsewhere

integument

variable body spotting ( J:88137 )

• extensive white trunk band and variable spotting elsewhere

Genotype
MGI:3779023

ht10

• Allelic Composition: Kit^W-2Btlr/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-2Btlr

pigmentation

decreased ear pigmentation ( J:133613 )

• mice heterozygous for this mutation have light ears

diluted coat color ( J:133613 )

belly spot ( J:133613 )

• heterozygous mutants have a white belly spot

variable body spotting ( J:133613 )

• some heterozygotes have white dorsal spots

decreased tail pigmentation ( J:133613 )

• heterozygous mutant mice have light colored tails

craniofacial

decreased ear pigmentation ( J:133613 )

• mice heterozygous for this mutation have light ears

hearing/vestibular/ear

decreased ear pigmentation ( J:133613 )

• mice heterozygous for this mutation have light ears

limbs/digits/tail

decreased tail pigmentation ( J:133613 )

• heterozygous mutant mice have light colored tails

integument

decreased ear pigmentation ( J:133613 )

• mice heterozygous for this mutation have light ears

diluted coat color ( J:133613 )

belly spot ( J:133613 )

• heterozygous mutants have a white belly spot

variable body spotting ( J:133613 )

• some heterozygotes have white dorsal spots

decreased tail pigmentation ( J:133613 )

• heterozygous mutant mice have light colored tails

growth/size/body

decreased ear pigmentation ( J:133613 )

• mice heterozygous for this mutation have light ears

Genotype
MGI:3813668

ht11

• Allelic Composition: Kit^W-34J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-34J/J

hematopoietic system

polycythemia ( J:6571 )

• borderline

Genotype
MGI:3813670

ht12

• Allelic Composition: Kit^W-35J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-35J/J

reproductive system

small testis ( J:6571 )

♂

hematopoietic system

polycythemia ( J:6571 )

• borderline

endocrine/exocrine glands

small testis ( J:6571 )

♂

Genotype
MGI:3813673

ht13

• Allelic Composition: Kit^W-37J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-37J/J

hematopoietic system

polycythemia ( J:6571 )

• borderline

pigmentation

irregular coat pigmentation ( J:6571 )

• some mice exhibit mosaic coat patterns

white spotting ( J:6571 )

• 85% of the coat is white with flecks of pigmented hair on the head, around the eyes, at the base of the ears and on the rump

integument

irregular coat pigmentation ( J:6571 )

• some mice exhibit mosaic coat patterns

white spotting ( J:6571 )

• 85% of the coat is white with flecks of pigmented hair on the head, around the eyes, at the base of the ears and on the rump

Genotype
MGI:3813677

ht14

• Allelic Composition: Kit^W-39J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-39J/J

hematopoietic system

macrocytic anemia ( J:6571 )

• mild, normochromic, macrocytic anemia

pigmentation

diluted coat color ( J:6571 )

• mice exhibit slight dilution of their dorsal and ventral coats

belly spot ( J:6571 )

• mice exhibit a large white belly spot

integument

diluted coat color ( J:6571 )

• mice exhibit slight dilution of their dorsal and ventral coats

belly spot ( J:6571 )

• mice exhibit a large white belly spot

Genotype
MGI:3033447

ht15

• Allelic Composition: Kit^W-3Bao/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-3Bao

pigmentation

variable body spotting ( J:88137 )

• extensive white trunk band and variable spotting elsewhere

integument

variable body spotting ( J:88137 )

• extensive white trunk band and variable spotting elsewhere

Genotype
MGI:3813679

ht16

• Allelic Composition: Kit^W-40J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-40J/J

reproductive system

reproductive system phenotype ( J:6571 )

N • mice are fertile

small testis ( J:6571 )

♂

hematopoietic system

polycythemia ( J:6571 )

• borderline

endocrine/exocrine glands

small testis ( J:6571 )

♂

Genotype
MGI:3813681

ht17

• Allelic Composition: Kit^W-41J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-41J/J

hematopoietic system

macrocytic anemia ( J:6571 )

• mild, normochromic, macrocytic anemia

pigmentation

diluted coat color ( J:6571 )

• mice exhibit slight dilution of their dorsal and ventral coats

belly spot ( J:6571 )

• mice exhibit small white belly spots

integument

diluted coat color ( J:6571 )

• mice exhibit slight dilution of their dorsal and ventral coats

belly spot ( J:6571 )

• mice exhibit small white belly spots

Genotype
MGI:2167486

ht18

• Allelic Composition: Kit^W-42J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-42J/J

Kit^W-42J/Kit⁺

endocrine/exocrine glands

abnormal ovarian follicle number ( J:6571 )

♀

small testis ( J:6571 )

♂

hematopoietic system

macrocytic anemia ( J:6571 )

• mild, normochromic, macrocytic anemia

integument

absent coat pigmentation ( J:6571 )

• white coat with some dark pigmentation on the ears

• sporadic incidence of patches of pigmented hair around ears and eyes or rump

irregular coat pigmentation ( J:6571 )

• mosaicism for large, sharply defined pigmented area

• attributed to heterogeneity for wild-type allele

pigmentation

absent coat pigmentation ( J:6571 )

• white coat with some dark pigmentation on the ears

• sporadic incidence of patches of pigmented hair around ears and eyes or rump

irregular coat pigmentation ( J:6571 )

• mosaicism for large, sharply defined pigmented area

• attributed to heterogeneity for wild-type allele

reproductive system

reproductive system phenotype ( J:36829 )

N • testes differentiation is not delayed

abnormal ovarian follicle number ( J:6571 )

♀

small testis ( J:6571 )

♂

Genotype
MGI:3813683

ht19

• Allelic Composition: Kit^W-43J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-43J/J

endocrine/exocrine glands

small testis ( J:6571 )

♂

hematopoietic system

polycythemia ( J:6571 )

• borderline

reproductive system

small testis ( J:6571 )

♂

Genotype
MGI:3843802

ht20

• Allelic Composition: Kit^W-55J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-55J/J

hematopoietic system

anemia ( J:28221 )

• mild

pigmentation

white spotting ( J:28221 )

integument

white spotting ( J:28221 )

Genotype
MGI:5578559

ht21

• Allelic Composition: Kit^W-85J/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-85J/GrsrJ

integument

white spotting ( J:212309 )

• heterozygotes have white spots on their otherwise black coats

pigmentation

white spotting ( J:212309 )

• heterozygotes have white spots on their otherwise black coats

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:212309 )

N • auditory brainstem response analysis at 28 days of age found normal thresholds

Genotype
MGI:3573948

ht22

• Allelic Composition: Kit^Wads/Kit⁺
• Genetic Background: C57BL/6J-Kit^Wads

pigmentation

belly spot ( J:96391 )

• a symmetrical cluster of white coat on the abdomen was observed

head spot ( J:96391 )

• incomplete penetrance; some animals have a head spot

variable body spotting ( J:96391 )

• small white spots on the back were observed

• most of the tail and the distal part of the legs displayed a white color

hematopoietic system

increased mean platelet volume ( J:96391 )

• slight elevation compared to controls

integument

belly spot ( J:96391 )

• a symmetrical cluster of white coat on the abdomen was observed

head spot ( J:96391 )

• incomplete penetrance; some animals have a head spot

variable body spotting ( J:96391 )

• small white spots on the back were observed

• most of the tail and the distal part of the legs displayed a white color

Genotype
MGI:2677344

ht23

• Allelic Composition: Kit^W-Bs/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-Bs

pigmentation

variable body spotting ( J:238 , J:157 )

• belly spot sometimes extends to dorsal surface (J:238)

• spotting on feet and tail also common (J:238)

• spotting pattern is unique (J:157)

integument

variable body spotting ( J:238 , J:157 )

• belly spot sometimes extends to dorsal surface (J:238)

• spotting on feet and tail also common (J:238)

• spotting pattern is unique (J:157)

Genotype
MGI:3778371

ht24

• Allelic Composition: Kit^W-Btlr/Kit⁺
• Genetic Background: C57BL/6J-Kit^W-Btlr

pigmentation

belly spot ( J:133270 )

• mice heterozygous for this mutation have white patches on the belly

integument

belly spot ( J:133270 )

• mice heterozygous for this mutation have white patches on the belly

Genotype
MGI:3029935

ht25

• Allelic Composition: Kit^W-ei/Kit⁺
• Genetic Background: C57BL-Kit^W-ei

pigmentation

irregular coat pigmentation ( J:28100 )

• consistently grey on head, shoulders and haunches; white elsewhere

• 4% of mice show spontaneous revertant black spotting especially in grey areas

integument

irregular coat pigmentation ( J:28100 )

• consistently grey on head, shoulders and haunches; white elsewhere

• 4% of mice show spontaneous revertant black spotting especially in grey areas

Genotype
MGI:3813877

ht26

• Allelic Composition: Kit^W-rio/Kit⁺
• Genetic Background: DBA/2-Kit^W-rio

pigmentation

white spotting ( J:29400 )

• mice exhibit an extensively white coat with few pigmented hairs

integument

white spotting ( J:29400 )

• mice exhibit an extensively white coat with few pigmented hairs

Genotype
MGI:3603339

ht27

• Allelic Composition: Kit^tm1Bpr/Kit⁺
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

digestive/alimentary system

abnormal digestive system morphology ( J:100778 )

• interstitial cells of Cajal (ICC) hyperplasia in the cecum and large bowel that is much less extensive than in homozygotes

increased gastrointestinal stromal tumor incidence ( J:100778 )

• develop small cecal gastrointestinal stromal tumors (GIST)

neoplasm

increased gastrointestinal stromal tumor incidence ( J:100778 )

• develop small cecal gastrointestinal stromal tumors (GIST)

pigmentation

pigmentation phenotype ( J:100778 )

N • normal coat color unlike homozygotes that have a white coat

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
gastrointestinal stromal tumor		DOID:9253	OMIM:606764	J:100778

Genotype
MGI:4849374

ht28

• Allelic Composition: Kit^W/Kit⁺
• Genetic Background: FL/1Re-Kit^W/J

hematopoietic system

high mean erythrocyte cell number ( J:24610 )

• elevated from birth onward

increased hematocrit ( J:24610 )

• slightly elevated from birth onward

Genotype
MGI:3813733

ht29

• Allelic Composition: Kit^W-ct/Kit⁺
• Genetic Background: involves: 101/H * C3H/HeH

hematopoietic system

macrocytic anemia ( J:7216 )

• mildly

Genotype
MGI:3036839

ht30

• Allelic Composition: Kit^W-19H/Kit⁺
• Genetic Background: involves: 101/H * C3H/HeH

mortality/aging

postnatal lethality, incomplete penetrance ( J:7681 )

• some are runted and die before weaning age of unknown causes

pigmentation

variable body spotting ( J:7681 )

• white spotting on feet, tail and belly; spotting elsewhere is possible but infrequent

growth/size/body

postnatal growth retardation ( J:7681 )

• some are small and runted

integument

variable body spotting ( J:7681 )

• white spotting on feet, tail and belly; spotting elsewhere is possible but infrequent

Genotype
MGI:3813600

ht31

• Allelic Composition: Kit^W-28H/Kit⁺
• Genetic Background: involves: 101/H * C3H/HeH

pigmentation

white spotting ( J:18375 )

• mice exhibit white spotting on the belly, forehead, tail and feet.

integument

white spotting ( J:18375 )

• mice exhibit white spotting on the belly, forehead, tail and feet.

Genotype
MGI:3813604

ht32

• Allelic Composition: Kit^W-29H/Kit⁺
• Genetic Background: involves: 101/H * C3H/HeH

pigmentation

diluted coat color ( J:18375 )

• mildly

white spotting ( J:18375 )

• extensive

integument

diluted coat color ( J:18375 )

• mildly

white spotting ( J:18375 )

• extensive

Genotype
MGI:3843928

ht33

• Allelic Composition: Kit^W-e/Kit⁺
• Genetic Background: involves: 101/H * C3H/HeH

pigmentation

diluted coat color ( J:13765 )

variable body spotting ( J:13765 )

• extensive white markings on head, back, and belly

integument

diluted coat color ( J:13765 )

variable body spotting ( J:13765 )

• extensive white markings on head, back, and belly

Genotype
MGI:3029932

ht34

• Allelic Composition: Kit^W-sh/Kit⁺
• Genetic Background: involves: 101/H * C3H/HeH * CBA

pigmentation

variable body spotting ( J:24351 )

• appears as a distinctive broad white sash

integument

variable body spotting ( J:24351 )

• appears as a distinctive broad white sash

Genotype
MGI:3576857

ht35

• Allelic Composition: Kit^d18/Kit⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

pigmentation

belly spot ( J:97533 )

integument

belly spot ( J:97533 )

Genotype
MGI:3045953

ht36

• Allelic Composition: Kit^tm2Ber/Kit⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

neonatal lethality, incomplete penetrance ( J:89602 )

• ~10% died during the neonatal period

• most heterozygotes survived for at least 1 year

pigmentation

absent coat pigmentation ( J:89602 )

• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs

white spotting ( J:89602 )

variable depigmentation ( J:89602 )

• observed in 2% to 5% of mice

• >90% of the body surface area white except around the ear

reproductive system

reproductive system phenotype ( J:89602 )

N • mice were fully fertile

integument

absent coat pigmentation ( J:89602 )

• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs

white spotting ( J:89602 )

variable depigmentation ( J:89602 )

• observed in 2% to 5% of mice

• >90% of the body surface area white except around the ear

Genotype
MGI:3045958

ht37

• Allelic Composition: Kit^tm1Ber/Kit⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

pigmentation

abnormal coat/hair pigmentation ( J:89602 )

absent coat pigmentation ( J:89602 )

• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs

white spotting ( J:89602 )

variable depigmentation ( J:89602 )

• observed in 2% to 5% of mice

• >90% of the body surface area white except around the ear

reproductive system

reproductive system phenotype ( J:89602 )

N • mice were fully fertile

integument

abnormal coat/hair pigmentation ( J:89602 )

absent coat pigmentation ( J:89602 )

• in regions where the coat was white, melanin pigment was absent from the hair shafts and melanocytes were absent from the hair bulbs

white spotting ( J:89602 )

variable depigmentation ( J:89602 )

• observed in 2% to 5% of mice

• >90% of the body surface area white except around the ear

Genotype
MGI:2178068

ht38

• Allelic Composition: Kit^tm1Bsm/Kit⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

pigmentation

belly spot ( J:61141 )

abnormal foot pigmentation ( J:61141 )

• white feet

non-pigmented tail tip ( J:61141 )

limbs/digits/tail

non-pigmented tail tip ( J:61141 )

integument

belly spot ( J:61141 )

abnormal foot pigmentation ( J:61141 )

• white feet

non-pigmented tail tip ( J:61141 )

Genotype
MGI:5510144

ht39

• Allelic Composition: Kit^tm5.1Bsm/Kit⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Cecal gastrointestinal stromal tumor and gastric/colonic interstatial cell of Cajal hyperplasia in Kit^tm5.1Bsm/Kit⁺ and Kit^tm4.1Bsm/Kit⁺ mice

mortality/aging

lethality, incomplete penetrance ( J:188434 )

premature death ( J:188434 )

neoplasm

increased gastrointestinal tumor incidence ( J:188434 )

• mice develop cecal tumors that are larger than in Kit^tm4.1Bsm heterozygotes

increased tumor growth/size ( J:188434 )

• compared to in Kit^tm4.1Bsm heterozygotes

digestive/alimentary system

interstitial cells of Cajal hyperplasia ( J:188434 )

• less pronounced in the stomach and colon than in Kit^tm4.1Bsm heterozygotes

increased gastrointestinal tumor incidence ( J:188434 )

• mice develop cecal tumors that are larger than in Kit^tm4.1Bsm heterozygotes

hematopoietic system

decreased mean corpuscular volume ( J:188434 )

Genotype
MGI:5442707

ht40

• Allelic Composition: Kit^tm4.1Bsm/Kit⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

Alopecia and 'red paw' in Kit^tm4.1Bsm/Kit⁺ mice

mortality/aging

premature death ( J:188434 )

• median survival is 14 months

• however, survival is improved compared to in Kit^tm5.1Bsm heterozygotes

hematopoietic system

enlarged spleen ( J:188434 )

spleen hyperplasia ( J:188434 )

• 1.5-fold without gross alterations in splenic architecture

increased erythroid progenitor cell number ( J:188434 )

• increased burst-forming unit erythroid (BFU-E) and erythroid (CFU-E) colonies and in the bone marrow and spleen

abnormal erythrocyte morphology ( J:188434 )

• smaller in diameter than wild-type cells

increased erythrocyte cell number ( J:188434 )

polycythemia ( J:188434 )

• microcytic erythrocytosis reminiscent of myeloproliferative neoplasms

increased hematocrit ( J:188434 )

• between 3 and 8 weeks of age

decreased mean corpuscular volume ( J:188434 )

• compared with Kit^tm5.1Bsm heterozygotes; without an increase in platelet count

increased mast cell number ( J:188434 )

• more pronounced mast cell hyperplasia in the skin compared to in Kit^tm5.1Bsm heterozygotes

• half of male mice exhibit accumulation of mast cells around Leydig cells unlike in wild-type mice

increased mean platelet volume ( J:188434 )

• without an increase in platelet count

digestive/alimentary system

interstitial cells of Cajal hyperplasia ( J:188434 )

• more pronounced in the stomach and colon than in Kit^tm5.1Bsm heterozygotes

small cecum ( J:188434 )

• reduced cecum length compared to in Kit^tm5.1Bsm heterozygotes

increased gastrointestinal tumor incidence ( J:188434 )

• mice develop cecal tumors that are smaller than in Kit^tm5.1Bsm

neoplasm

increased gastrointestinal tumor incidence ( J:188434 )

• mice develop cecal tumors that are smaller than in Kit^tm5.1Bsm

decreased tumor growth/size ( J:188434 )

• smaller tumors than in Kit^tm5.1Bsm heterozygotes

integument

alopecia ( J:188434 )

• intermittent partial alopecia between P15 and P40 associated with increased mast cells

reddish skin ( J:188434 )

• reddening of the paws from P40 onward

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:188434 )

• mice exhibit resistance to imatinib and dasatinib in vivo compared with Kit^tm5.1Bsm heterozygotes

• however, sunitinib and sorafenib overcomes resistance

immune system

enlarged spleen ( J:188434 )

spleen hyperplasia ( J:188434 )

• 1.5-fold without gross alterations in splenic architecture

increased mast cell number ( J:188434 )

• more pronounced mast cell hyperplasia in the skin compared to in Kit^tm5.1Bsm heterozygotes

• half of male mice exhibit accumulation of mast cells around Leydig cells unlike in wild-type mice

growth/size/body

enlarged spleen ( J:188434 )

spleen hyperplasia ( J:188434 )

• 1.5-fold without gross alterations in splenic architecture

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
gastrointestinal stromal tumor		DOID:9253	OMIM:606764	J:188434

Genotype
MGI:3770811

ht41

• Allelic Composition: Kit^tm1Alf/Kit⁺
• Genetic Background: involves: 129S2/SvPas

pigmentation

white spotting ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip resulting in white feet and a white tail tip

non-pigmented tail tip ( J:36230 )

• white tail tip

reproductive system

abnormal oocyte morphology ( J:67923 )

♀ • oocyte growth is altered

abnormal male germ cell morphology ( J:103157 )

♂ • males exhibit a higher number of spermatozoa without acrosomal contents

oligozoospermia ( J:103157 )

♂ • reduction in epididymal sperm counts

asthenozoospermia ( J:103157 )

♂ • decrease in sperm motility

abnormal female reproductive system morphology ( J:67923 )

♀

abnormal ovarian follicle number ( J:67923 )

♀ • ovaries contain increased numbers of type 5a follicles and fewer numbers of type 5b (preantral follicles) follicles

decreased primordial ovarian follicle number ( J:67923 )

♀ • primordial follicle numbers decrease with increasing age

abnormal ovarian folliculogenesis ( J:67923 )

♀ • antrum formation in preantral follicles is disrupted at P20, as fewer preantral follicles with 3 or 4 layers of granulosa cells develop an antral cavity

abnormal male reproductive system morphology ( J:103157 )

♂

decreased testis weight ( J:103157 )

♂ • testes weights are 50% lower than in wild-type

♂ • however, no difference in seminal vesicle weight

decreased epididymis weight ( J:103157 )

♂ • epididymides weights are 25% lower than in wild-type before 30 days of age; at 30 days of age when no spermatozoa are present, weights do not differ

reduced male fertility ( J:103157 )

♂ • in vivo and in vitro fertility is greatly reduced in males

♂ • female fertility is normal

limbs/digits/tail

non-pigmented tail tip ( J:36230 )

• white tail tip

endocrine/exocrine glands

abnormal ovarian follicle number ( J:67923 )

♀ • ovaries contain increased numbers of type 5a follicles and fewer numbers of type 5b (preantral follicles) follicles

decreased primordial ovarian follicle number ( J:67923 )

♀ • primordial follicle numbers decrease with increasing age

abnormal ovarian folliculogenesis ( J:67923 )

♀ • antrum formation in preantral follicles is disrupted at P20, as fewer preantral follicles with 3 or 4 layers of granulosa cells develop an antral cavity

decreased testis weight ( J:103157 )

♂ • testes weights are 50% lower than in wild-type

♂ • however, no difference in seminal vesicle weight

embryo

abnormal melanoblast migration ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip

integument

white spotting ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip resulting in white feet and a white tail tip

non-pigmented tail tip ( J:36230 )

• white tail tip

cellular

abnormal oocyte morphology ( J:67923 )

♀ • oocyte growth is altered

abnormal male germ cell morphology ( J:103157 )

♂ • males exhibit a higher number of spermatozoa without acrosomal contents

oligozoospermia ( J:103157 )

♂ • reduction in epididymal sperm counts

abnormal melanoblast migration ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip

asthenozoospermia ( J:103157 )

♂ • decrease in sperm motility

Genotype
MGI:5578538

ht42

• Allelic Composition: Kit^W-84J/Kit⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

integument

white spotting ( J:173520 )

pigmentation

white spotting ( J:173520 )

Genotype
MGI:3773053

ht43

• Allelic Composition: Kit^tm1Shta/Kit⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

digestive/alimentary system

abnormal digestive system morphology ( J:130890 )

• mice exhibit spindle-shaped cell proliferations in the lower esophagus, stomach, proximal duodenum and colon unlike in wild-type mice

• however, small intestines are normal

abnormal esophagus morphology ( J:130890 )

• mice exhibit black lesions at the lower esophagus due to melanocyte aggregations in muscularis propria and adventitia

increased gastrointestinal stromal tumor incidence ( J:130890 )

• mice exhibit a small but apparent whitish, linear tumor in the cecum

• mice develop cecal tumors at any age

neoplasm

increased gastrointestinal stromal tumor incidence ( J:130890 )

• mice exhibit a small but apparent whitish, linear tumor in the cecum

• mice develop cecal tumors at any age

reproductive system

reproductive system phenotype ( J:130890 )

N • unlike with mice carrying other alleles of this gene, mice exhibit normal spermatogenesis

Genotype
MGI:4940018

ht44

• Allelic Composition: Kit^tm1Rosay/Kit⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

integument

white spotting ( J:168676 )

• mice exhibit white patches at the end of the tail and on the belly and white paws compared with wild-type mice

belly spot ( J:168676 )

pigmentation

white spotting ( J:168676 )

• mice exhibit white patches at the end of the tail and on the belly and white paws compared with wild-type mice

belly spot ( J:168676 )

Genotype
MGI:2663997

ht45

• Allelic Composition: Kit^tm2Bsm/Kit⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

mortality/aging

premature death ( J:83616 )

• starting at 4 weeks of age, heterozygotes develop symptoms of disease and eventually die from pathology in the GI tract, showing a 50% survival rate at 9 months of age

digestive/alimentary system

abnormal esophagus morphology ( J:83616 )

• 7 of 14 heterozygotes exhibit a well-defined, black-pigmented distal esophagus at the gastro-esophageal junction

• EM analysis indicates melanosomes, discontinuous external lamina, short cell processes, and single centrally located nucleoli

interstitial cells of Cajal hyperplasia ( J:83616 )

abnormal cecum morphology ( J:83616 )

• all (14 of 14) heterozygotes exhibit a firm white nodular mass of variable size (1 mm to 2 cm) in the cecum

distended cecum ( J:83616 )

• 9 of 14 heterozygotes display a distended cecum with clear fluid or pus-like contents

• atrophy of the colonic folds, lumen distension, and in one case abscess formation associated with acute serositis are observed

enlarged cecum ( J:83616 )

• 9 of 14 heterozygotes display an enlarged cecum

distended ileum ( J:83616 )

• 12 of 14 heterozygotes display variable distention of the distal ileum (mega-ileum) ending at the level of the cecum

• however, the remaining small intestine, stomach, colon, and anus appear morphologically normal

increased gastrointestinal stromal tumor incidence ( J:83616 )

• heterozygotes exhibit neoplastic lesions of GISTs predominantly in the myenteric plexus of the cecum

neoplasm

increased gastrointestinal stromal tumor incidence ( J:83616 )

• heterozygotes exhibit neoplastic lesions of GISTs predominantly in the myenteric plexus of the cecum

pigmentation

hyperpigmentation ( J:83616 )

• 7 of 14 heterozygotes display hypepigmentation of the distal esophagus at the gastro-esophageal junction

• 5 of 6 heterozygotes with a dark distal esophagus contain melanosomes specifically within the myenteric plexus

• pigmented areas of the esophageal myenteric plexus contain large, ovoid cells with abundant cytoplasm filled with numerous stage IV melanosomes, and are surrounded by a discontinuous linear basal lamina

• pigmented cells are intermixed with other cell components of the myenteric plexus, including Schwann cells, axonal processes, and interstitial cells of Cajal

immune system

increased mast cell degranulation ( J:83616 )

• heterozygotes exhibit extracellular granules in the vicinity of mast cells in the dorsal skin

increased mast cell number ( J:83616 )

• heterozygotes show a 4-fold increase in the number of mast cells in the dorsal skin and peritoneum

hematopoietic system

increased mast cell degranulation ( J:83616 )

• heterozygotes exhibit extracellular granules in the vicinity of mast cells in the dorsal skin

increased mast cell number ( J:83616 )

• heterozygotes show a 4-fold increase in the number of mast cells in the dorsal skin and peritoneum

reproductive system

reduced fertility ( J:83616 )

• both male and female heterozygotes are fertile but display a progressive decline in fertility with increasing age

nervous system

abnormal myenteric nerve plexus morphology ( J:83616 )

• all (6 of 6) heterozygotes display patchy hyperplasia of the myenteric plexus of the stomach, cecum and large intestine

• 3 of 6 heterozygotes display hyperplasia of the myenteric plexus in the proximal duodenum

• however, no myenteric plexus hyperplasia is observed in the morphologically normal distal duodenum, jejunum, and distended ileum

• in addition, 5 of 6 heterozygotes exhibit patchy thickening/hyperplasia of the esophageal myenteric plexus, and hyperpigmented cells are found specifically within the myenteric plexus of the of distal esophagus

cellular

increased mast cell degranulation ( J:83616 )

• heterozygotes exhibit extracellular granules in the vicinity of mast cells in the dorsal skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
gastrointestinal stromal tumor		DOID:9253	OMIM:606764	J:83616

Genotype
MGI:2175085

ht46

• Allelic Composition: Kit^W-39H/Kit⁺
• Genetic Background: involves: BALB/cCrl * C3H/HeNCrl

pigmentation

abnormal coat/hair pigmentation ( J:63816 )

head blaze ( J:169366 )

• occasionally a white head blaze

white spotting ( J:63816 , J:169366 )

belly spot ( J:63816 , J:169366 )

• head and belly spotting that may extend up the flanks (J:63816)

integument

abnormal coat/hair pigmentation ( J:63816 )

head blaze ( J:169366 )

• occasionally a white head blaze

white spotting ( J:63816 , J:169366 )

belly spot ( J:63816 , J:169366 )

• head and belly spotting that may extend up the flanks (J:63816)

Genotype
MGI:3813891

ht47

• Allelic Composition: Kit^W-s/Kit⁺
• Genetic Background: involves: BRS

pigmentation

white spotting ( J:15330 )

• mice exhibit white spotting without dilution

integument

white spotting ( J:15330 )

• mice exhibit white spotting without dilution

Genotype
MGI:3813809

ht48

• Allelic Composition: Kit^W-j/Kit⁺
• Genetic Background: involves: C3H

pigmentation

white spotting ( J:3398 )

• white spotting is more extensive than in Kit^W heterozygotes

integument

white spotting ( J:3398 )

• white spotting is more extensive than in Kit^W heterozygotes

Genotype
MGI:3813593

ht49

• Allelic Composition: Kit^W-18J/Kit⁺
• Genetic Background: involves: C3HeB/Fe * C57BL/6

integument

white spotting ( J:101977 )

pigmentation

white spotting ( J:101977 )

Genotype
MGI:3760793

ht50

• Allelic Composition: Kit^Whc1/Kit⁺
• Genetic Background: involves: C3HeB/Fe * C57BL/6

pigmentation

head blaze ( J:125831 )

belly spot ( J:125831 )

integument

head blaze ( J:125831 )

belly spot ( J:125831 )

Genotype
MGI:2176285

ht51

• Allelic Composition: Kit^W-82J/Kit⁺
• Genetic Background: involves: C3HeB/FeLe

pigmentation

abnormal coat/hair pigmentation ( J:75289 )

abnormal skin pigmentation ( J:75289 )

integument

abnormal coat/hair pigmentation ( J:75289 )

abnormal skin pigmentation ( J:75289 )

Genotype
MGI:3813831

ht52

• Allelic Composition: Kit^W-x/Kit⁺
• Genetic Background: involves: C3H/HeJ

pigmentation

abnormal coat/hair pigmentation ( J:3398 )

• authors state that this mouse in indistinguishable from Kit^W mice

integument

abnormal coat/hair pigmentation ( J:3398 )

• authors state that this mouse in indistinguishable from Kit^W mice

Genotype
MGI:3779025

ht53

• Allelic Composition: Kit^W-2Btlr/Kit⁺
• Genetic Background: involves: C3H/HeN * C57BL/6

pigmentation

head blaze ( J:133613 )

• Background Sensitivity: on this mixed genetic background, heterozygous mutants often present with a white belly and a white spindle-shaped forehead spot

white spotting ( J:133613 )

• Background Sensitivity: on this mixed genetic background, heterozygous mutants often present with a white belly and a white spindle-shaped forehead spot

integument

head blaze ( J:133613 )

• Background Sensitivity: on this mixed genetic background, heterozygous mutants often present with a white belly and a white spindle-shaped forehead spot

white spotting ( J:133613 )

• Background Sensitivity: on this mixed genetic background, heterozygous mutants often present with a white belly and a white spindle-shaped forehead spot

Genotype
MGI:3055548

ht54

• Allelic Composition: Kit^W-f/Kit⁺
• Genetic Background: involves: C3H/HePas

pigmentation

diluted coat color ( J:27513 )

• typical dilution of pigmented areas not observed on strain of origin but is noted on C57BL/6 background

belly spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

head spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

non-pigmented tail tip ( J:6187 )

hematopoietic system

macrocytic anemia ( J:6187 )

limbs/digits/tail

non-pigmented tail tip ( J:6187 )

integument

diluted coat color ( J:27513 )

• typical dilution of pigmented areas not observed on strain of origin but is noted on C57BL/6 background

belly spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

head spot ( J:6187 )

• sharply demarcated but variable in size, sometimes reduced to a few hairs

• presence is background sensitive

non-pigmented tail tip ( J:6187 )

Genotype
MGI:5000282

ht55

• Allelic Composition: Kit^W-v/Kit⁺
• Genetic Background: involves: C57BL

pigmentation

diluted coat color ( J:2447 )

• slightly diluted coat color

variable body spotting ( J:2447 )

• variable amount of white spotting

integument

diluted coat color ( J:2447 )

• slightly diluted coat color

variable body spotting ( J:2447 )

• variable amount of white spotting

reproductive system

reproductive system phenotype ( J:2447 )

N • fertile

Genotype
MGI:3029324

ht56

• Allelic Composition: Kit^Ssm/Kit⁺
• Genetic Background: involves: C57BL/10 * Non-inbred

pigmentation

variable body spotting ( J:14020 )

• white spotting on belly, fore and hind limbs, and tail

reproductive system

male infertility ( J:14020 )

♂ • sterile on B10.M/Y genetic background; fertile on YT/Y,CBA/CaY,DBA/2JY, and A.CA/Y

integument

variable body spotting ( J:14020 )

• white spotting on belly, fore and hind limbs, and tail

Genotype
MGI:2387551

ht57

• Allelic Composition: Kit^W-v/Kit⁺
• Genetic Background: involves: C57BL/6

hematopoietic system

macrocytic anemia ( J:3400 )

• slightly macrocytic

Genotype
MGI:3813816

ht58

• Allelic Composition: Kit^W-Jic/Kit⁺
• Genetic Background: involves: C57BL/6

immune system

decreased mast cell number ( J:27513 )

• mice exhibit fewer mast cells in the skin than wild-type mice

hematopoietic system

decreased erythrocyte cell number ( J:27513 )

decreased mast cell number ( J:27513 )

• mice exhibit fewer mast cells in the skin than wild-type mice

pigmentation

diluted coat color ( J:27513 )

white spotting ( J:27513 )

integument

diluted coat color ( J:27513 )

white spotting ( J:27513 )

Genotype
MGI:3813820

ht59

• Allelic Composition: Kit^W-37J/Kit⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J

immune system

decreased mast cell number ( J:27513 )

• mice exhibit slightly fewer mast cells in the skin than wild-type mice

hematopoietic system

decreased mast cell number ( J:27513 )

• mice exhibit slightly fewer mast cells in the skin than wild-type mice

pigmentation

diluted coat color ( J:27513 )

• slightly

white spotting ( J:27513 )

integument

diluted coat color ( J:27513 )

• slightly

white spotting ( J:27513 )

Genotype
MGI:3813818

ht60

• Allelic Composition: Kit^W-42J/Kit⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J * WB

immune system

decreased mast cell number ( J:27513 )

• mice exhibit fewer mast cells in the skin than wild-type mice

pigmentation

diluted coat color ( J:27513 )

white spotting ( J:27513 )

hematopoietic system

decreased erythrocyte cell number ( J:27513 )

decreased mast cell number ( J:27513 )

• mice exhibit fewer mast cells in the skin than wild-type mice

integument

diluted coat color ( J:27513 )

white spotting ( J:27513 )

Genotype
MGI:3813878

ht61

• Allelic Composition: Kit^W-rio/Kit⁺
• Genetic Background: involves: C57BL/6 * DBA/2

normal phenotype

reversion by mitotic recombination ( J:29400 )

• 3.6% of mice exhibit revertant pigmented patches with most revertant cells exhibiting loss of heterozygosity following mitotic recombination between the centromere and Kit locus

pigmentation

white spotting ( J:29400 )

• mice exhibit an extensively white coat with few pigmented hairs

integument

white spotting ( J:29400 )

• mice exhibit an extensively white coat with few pigmented hairs

Genotype
MGI:3813709

ht62

• Allelic Composition: Kit^W-51J/Kit⁺
• Genetic Background: involves: C57BL/6J

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:3813842

ht63

• Allelic Composition: Kit^W-70J/Kit⁺
• Genetic Background: involves: C57BL/6J

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:3813717

ht64

• Allelic Composition: Kit^W-59J/Kit⁺
• Genetic Background: involves: C57BL/6J

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:3813706

ht65

• Allelic Composition: Kit^W-49J/Kit⁺
• Genetic Background: involves: C57BL/6J

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:4822200

ht66

• Allelic Composition: Kit^W-3Bao/Kit⁺
• Genetic Background: involves: C57BL/6J

reproductive system

abnormal seminiferous tubule morphology ( J:163026 )

♂ • a few seminiferous tubules are filled a diluted pink substance instead of speratogenic cells unlike in wild-type mice

♂ • dysplastic seminiferous tubules are reduced in diameter compared to in wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:163026 )

N • at 2 months, mice exhibit normal peripheral red blood cell counts

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:163026 )

♂ • a few seminiferous tubules are filled a diluted pink substance instead of speratogenic cells unlike in wild-type mice

♂ • dysplastic seminiferous tubules are reduced in diameter compared to in wild-type mice

pigmentation

white spotting ( J:163026 )

• mice exhibit white spots on the abdomen, white distal limbs, and white tipped tails unlike wild-type mice

belly spot ( J:163026 )

integument

white spotting ( J:163026 )

• mice exhibit white spots on the abdomen, white distal limbs, and white tipped tails unlike wild-type mice

belly spot ( J:163026 )

Genotype
MGI:4822201

ht67

• Allelic Composition: Kit^W-2Bao/Kit⁺
• Genetic Background: involves: C57BL/6J

reproductive system

abnormal seminiferous tubule morphology ( J:163026 )

♂ • mice exhibit contorted seminiferous tubules unlike wild-type mice

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:163026 )

♂ • mice exhibit contorted seminiferous tubules unlike wild-type mice

Genotype
MGI:4822203

ht68

• Allelic Composition: Kit^Wads/Kit⁺
• Genetic Background: involves: C57BL/6J

reproductive system

abnormal seminiferous tubule morphology ( J:163026 )

♂ • mice exhibit contorted seminiferous tubules unlike wild-type mice

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:163026 )

♂ • mice exhibit contorted seminiferous tubules unlike wild-type mice

Genotype
MGI:3813675

ht69

• Allelic Composition: Kit^W-38J/Kit⁺
• Genetic Background: involves: C57BL/6J

reproductive system

small testis ( J:6571 )

♂

hematopoietic system

polycythemia ( J:6571 )

• borderline

endocrine/exocrine glands

small testis ( J:6571 )

♂

Genotype
MGI:5523968

ht70

• Allelic Composition: Kit^Wps/Kit⁺
• Genetic Background: involves: C57BL/6J * CBA/CaJ

integument

belly spot ( J:196572 )

pigmentation

belly spot ( J:196572 )

Genotype
MGI:3813828

ht71

• Allelic Composition: Kit^W-v/Kit⁺
• Genetic Background: involves: C57BL * C57BL/6

immune system

decreased mast cell number ( J:27513 )

• mice exhibit fewer mast cells in the skin than wild-type mice

hematopoietic system

decreased erythrocyte cell number ( J:27513 )

decreased mast cell number ( J:27513 )

• mice exhibit fewer mast cells in the skin than wild-type mice

pigmentation

diluted coat color ( J:27513 )

white spotting ( J:27513 )

integument

diluted coat color ( J:27513 )

white spotting ( J:27513 )

Genotype
MGI:4431037

ht72

• Allelic Composition: Kit^W-v/Kit⁺
• Genetic Background: involves: C57BL * DBA

pigmentation

diluted coat color ( J:125080 )

belly spot ( J:125080 )

• a spot is always present on the belly

head spot ( J:125080 )

• a head spot frequently but not always occurs

hematopoietic system

macrocytic anemia ( J:125080 )

• mild macrocytic anemia

integument

diluted coat color ( J:125080 )

belly spot ( J:125080 )

• a spot is always present on the belly

head spot ( J:125080 )

• a head spot frequently but not always occurs

Genotype
MGI:3813731

ht73

• Allelic Composition: Kit^W-b/Kit⁺
• Genetic Background: involves: C57BL/St

pigmentation

diluted coat color ( J:13078 )

• mice exhibit a pronouced decrease in the pigment granules in the base of the shaft of colored hair

white spotting ( J:13078 )

• mice are more extensively spotted than Kit^W-v heterozygotes with a frontal blaze

integument

diluted coat color ( J:13078 )

• mice exhibit a pronouced decrease in the pigment granules in the base of the shaft of colored hair

white spotting ( J:13078 )

• mice are more extensively spotted than Kit^W-v heterozygotes with a frontal blaze

Genotype
MGI:3029836

ht74

• Allelic Composition: Kit^W-57J/Kit⁺
• Genetic Background: involves: C58/J

pigmentation

belly spot ( J:38382 )

integument

belly spot ( J:38382 )

Genotype
MGI:3813705

ht75

• Allelic Composition: Kit^W-45J/Kit⁺
• Genetic Background: involves: DBA/2J

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:3813861

ht76

• Allelic Composition: Kit^W-73J/Kit⁺
• Genetic Background: involves: DBA/2J

pigmentation

white spotting ( J:16572 )

• extensive dorsally and ventrally

integument

white spotting ( J:16572 )

• extensive dorsally and ventrally

Genotype
MGI:3053007

ht77

• Allelic Composition: Kit^W-pw/Kit⁺
• Genetic Background: involves: STOCK Prop1^df Myo5a^d Bmp5^se

pigmentation

absent coat pigmentation ( J:13655 )

• in combination with W^v mice are white with black eyes

white spotting ( J:13655 )

• extensive white spotting; pigmentation predominantly found on the head especially nose, around eyes, and base of ears and base of tail

• small pigmented areas are found occasionally on hips and base of shoulders

reproductive system

female infertility ( J:13655 )

♀ • in combination with W^v

male infertility ( J:13655 )

♂ • in combination with W^v

integument

absent coat pigmentation ( J:13655 )

• in combination with W^v mice are white with black eyes

white spotting ( J:13655 )

• extensive white spotting; pigmentation predominantly found on the head especially nose, around eyes, and base of ears and base of tail

• small pigmented areas are found occasionally on hips and base of shoulders

Genotype
MGI:3770430

ht78

• Allelic Composition: Kit^W-bd/Kit⁺
• Genetic Background: involves: STOCK Rw Fgf5^go Vps33a^bf

pigmentation

belted ( J:14074 )

• mice exhibit a broad band of depigmentation on the trunk

embryo

abnormal melanoblast morphology ( J:38382 )

• at E10.5 and E11.8, melanoblast numbers are reduced compared to in wild-type mice

nervous system

abnormal melanoblast morphology ( J:38382 )

• at E10.5 and E11.8, melanoblast numbers are reduced compared to in wild-type mice

integument

belted ( J:14074 )

• mice exhibit a broad band of depigmentation on the trunk

Genotype
MGI:3813823

ht79

• Allelic Composition: Kit^W-n/Kit⁺
• Genetic Background: involves: WB

pigmentation

white spotting ( J:27513 )

integument

white spotting ( J:27513 )

Genotype
MGI:3813730

ht80

• Allelic Composition: Kit^W-a/Kit⁺
• Genetic Background: involves: Z

pigmentation

belly blaze ( J:28886 )

belly spot ( J:28886 )

integument

belly blaze ( J:28886 )

belly spot ( J:28886 )

Genotype
MGI:5306973

ht81

• Allelic Composition: Kit^W-31H/Kit⁺
• Genetic Background: Not Specified

integument

abnormal coat/hair pigmentation ( J:180729 )

• greying of coat

belly spot ( J:180729 )

head spot ( J:180729 )

absent skin pigmentation ( J:180729 )

• white feet

pigmentation

abnormal coat/hair pigmentation ( J:180729 )

• greying of coat

belly spot ( J:180729 )

head spot ( J:180729 )

absent skin pigmentation ( J:180729 )

• white feet

Genotype
MGI:3813590

ht82

• Allelic Composition: Kit^W-17J/Kit⁺
• Genetic Background: Not Specified

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:3813595

ht83

• Allelic Composition: Kit^W-24J/Kit⁺
• Genetic Background: Not Specified

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:3842474

ht84

• Allelic Composition: Kit^W-v/Kit⁺
• Genetic Background: Not Specified

pigmentation

abnormal coat/hair pigmentation ( J:2447 )

diluted coat color ( J:2447 )

• slightly diluted coat color

variable body spotting ( J:2447 )

• variable amounts of white spotting

integument

abnormal coat/hair pigmentation ( J:2447 )

diluted coat color ( J:2447 )

• slightly diluted coat color

variable body spotting ( J:2447 )

• variable amounts of white spotting

reproductive system

reproductive system phenotype ( J:2447 )

N • fertile

Genotype
MGI:5306978

ht85

• Allelic Composition: Kit^W-38H/Kit⁺
• Genetic Background: Not Specified

integument

white spotting ( J:180729 )

• spotting on head, back, and belly

belly spot ( J:180729 )

head spot ( J:180729 )

pigmentation

white spotting ( J:180729 )

• spotting on head, back, and belly

belly spot ( J:180729 )

head spot ( J:180729 )

Genotype
MGI:3055567

ht86

• Allelic Composition: Kit^W-n/Kit⁺
• Genetic Background: Not Specified

pigmentation

diluted coat color ( J:12107 )

• typical dilution of pigmented areas not observed

irregular coat pigmentation ( J:12107 )

• extensive depigmented areas lacking a defined pattern

integument

diluted coat color ( J:12107 )

• typical dilution of pigmented areas not observed

irregular coat pigmentation ( J:12107 )

• extensive depigmented areas lacking a defined pattern

Genotype
MGI:3813721

ht87

• Allelic Composition: Kit^W-80J/Kit⁺
• Genetic Background: Not Specified

integument

white spotting ( J:78381 )

pigmentation

white spotting ( J:78381 )

Genotype
MGI:2175088

ht88

• Allelic Composition: Kit^W/Kit⁺
• Genetic Background: Not Specified

pigmentation

abnormal coat/hair pigmentation ( J:12955 )

irregular coat pigmentation ( J:12955 )

• pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance

variable body spotting ( J:12955 )

• Background Sensitivity: variable amounts of white spotting

hematopoietic system

hematopoietic system phenotype ( J:14978 )

N • blood parameters are normal

reproductive system

reproductive system phenotype ( J:14978 )

N • system is normal

integument

abnormal coat/hair pigmentation ( J:12955 )

irregular coat pigmentation ( J:12955 )

• pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance

variable body spotting ( J:12955 )

• Background Sensitivity: variable amounts of white spotting

Genotype
MGI:5306976

ht89

• Allelic Composition: Kit^W-32H/Kit⁺
• Genetic Background: Not Specified

integument

abnormal coat/hair pigmentation ( J:180729 )

• greying of coat

belly spot ( J:180729 )

head spot ( J:180729 )

absent skin pigmentation ( J:180729 )

• white feet

pigmentation

abnormal coat/hair pigmentation ( J:180729 )

• greying of coat

belly spot ( J:180729 )

head spot ( J:180729 )

absent skin pigmentation ( J:180729 )

• white feet

Genotype
MGI:5545743

cn90

• Allelic Composition: Kit^{tm1(cre/ERT2)Dsa}/Kit⁺; Prkg1^tm2Naw/Prkg1^tm2Naw
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

digestive/alimentary system

abnormal gastrointestinal motility ( J:204737 )

• significant GI motor dysfunction is observed with tamoxifen treatment

abnormal intestinal peristalsis ( J:204737 )

• change in contraction frequency is observed in tamoxifen-treated mutants

• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice

abnormal intestinal transit time ( J:204737 )

• GI transit time is increased by about 2 hours in treated mutants

muscle

abnormal intestinal peristalsis ( J:204737 )

• change in contraction frequency is observed in tamoxifen-treated mutants

• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice

Genotype
MGI:5545742

cn91

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺; Kit^{tm1(cre/ERT2)Dsa}/Kit⁺
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

digestive/alimentary system

abnormal gastrointestinal motility ( J:204737 )

• significantly disturbed after 3 days of tamoxifen treatment (which results in loss of more than 50% of insterstitial cells of Cajal (ICCs)

abnormal intestinal peristalsis ( J:204737 )

• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity

abnormal intestinal transit time ( J:204737 )

• total GI transit time is increased to more than 5 hours; similar transit time is measured in tamoxifen-treated mutants that have been repopulated with wild-type mast cells (by adaptive BM transplant)

impaired gastric peristalsis ( J:204737 )

• tamoxifen-treated mice have delayed gastric emptying

nervous system

abnormal synaptic transmission ( J:204737 )

• in tamoxifen treated mice, excitatory enteric neurotransmission is blocked as result of ICC depletion

muscle

abnormal intestinal peristalsis ( J:204737 )

• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity

Genotype
MGI:4849372

cx92

• Allelic Composition: f/f; Kit^W/Kit⁺
• Genetic Background: FL/1Re-Kit^W/J

growth/size/body

decreased body weight ( J:24610 )

• although slightly reduced in body weight relative to controls this is less severe than in flexed-tail homozygotes wildtype at the Kit locus

hematopoietic system

abnormal erythrocyte cell number ( J:24610 )

• the reduction in erythrocyte cell number at birth is less severe than in flex-tail homozygotes that are wildtype at the Kit locus and by 7 days of age the count is higher than normal and this persists

decreased hematocrit ( J:24610 )

• decreased at birth, but closer to normal values than in flexed-tail homozgyotes that are wildtype at the Kit locus

decreased mean corpuscular volume ( J:24610 )

• from birth onward more severe decrease in erythrocyte volume than in flexed-tail homozygotes wildtype at the Kit locus

pigmentation

white spotting ( J:24610 )

• the amount of white pigmentation is greater than the sum of the white pigmentation of the distinct mutants, with females having an average of 54.7% white on the ventrum and males having an average of 59.7%

integument

white spotting ( J:24610 )

• the amount of white pigmentation is greater than the sum of the white pigmentation of the distinct mutants, with females having an average of 54.7% white on the ventrum and males having an average of 59.7%

Genotype
MGI:4849373

cx93

• Allelic Composition: f/f⁺; Kit^W/Kit⁺
• Genetic Background: FL/1Re-Kit^W/J

pigmentation

white spotting ( J:24610 )

• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively

integument

white spotting ( J:24610 )

• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively

Genotype
MGI:4431075

cx94

• Allelic Composition: Kit^W-v/Kit⁺; Rw/Rw⁺
• Genetic Background: involves: 101/H * C3H/HeH * C57BL

pigmentation

abnormal coat/hair pigmentation ( J:125080 )

• the top of the head is white and there is some heavily diluted fur on the sides of the head and some dorsal regions of the body

irregular coat pigmentation ( J:125080 )

head spot ( J:125080 )

integument

abnormal coat/hair pigmentation ( J:125080 )

• the top of the head is white and there is some heavily diluted fur on the sides of the head and some dorsal regions of the body

irregular coat pigmentation ( J:125080 )

head spot ( J:125080 )

Genotype
MGI:2652596

cx95

• Allelic Composition: Kit^W-v/Kit⁺; Snai2^tm2Grid/Snai2^tm2Grid
• Genetic Background: involves: 129S1/Sv * C57BL

pigmentation

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

integument

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

Genotype
MGI:2652598

cx96

• Allelic Composition: Kit^W-v/Kit⁺; Snai2^tm2Grid/Snai2⁺
• Genetic Background: involves: 129S1/Sv * C57BL

pigmentation

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

integument

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

Genotype
MGI:5316641

cx97

• Allelic Composition: Mitf^tm5.1Arnh/Mitf^tm5.1Arnh; Kit^tm1Alf/Kit⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N

pigmentation

abnormal coat/hair pigmentation ( J:182722 )

belly spot ( J:182722 )

• slightly larger belly spots

abnormal melanocyte morphology ( J:182722 )

• more melanocytes around the eyes at E15.5 and at birth compared to controls involving Mitf^tm7.1Arnh

abnormal hair follicle melanocyte morphology ( J:182722 )

• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitf^tm7.1Arnh

integument

abnormal coat/hair pigmentation ( J:182722 )

abnormal hair follicle melanocyte morphology ( J:182722 )

• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitf^tm7.1Arnh

belly spot ( J:182722 )

• slightly larger belly spots

Genotype
MGI:5316642

cx98

• Allelic Composition: Mitf^tm7.1Arnh/Mitf^tm7.1Arnh; Kit^tm1Alf/Kit⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N

pigmentation

belly spot ( J:182722 )

• slightly larger belly spot

integument

belly spot ( J:182722 )

• slightly larger belly spot

Genotype
MGI:3783653

cx99

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H; Kit^tm1Alf/Kit⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

pigmentation

belted ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

white spotting ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

integument

belted ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

white spotting ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

Genotype
MGI:4940020

cx100

• Allelic Composition: Kit^tm1Rosay/Kit⁺; Lep^ob/Lep^ob
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

digestive/alimentary system

abnormal interstitial cell of Cajal morphology ( J:168676 )

• interstitial cells of Cajal networks are disrupted during the development of diabetes unlike in Kit^tm1Rosan heterozygotes

• mice exhibit loss of interstitial cells of Cajal unlike Kit^tm1Rosan heterozygotes

growth/size/body

obese ( J:168676 )

• by 4 to 6 weeks of age

homeostasis/metabolism

hyperglycemia ( J:168676 )

• by 10 to 12 weeks of age

integument

white spotting ( J:168676 )

• mice exhibit white paws and tail unlike wild-type mice

pigmentation

white spotting ( J:168676 )

• mice exhibit white paws and tail unlike wild-type mice

Genotype
MGI:3778813

cx101

• Allelic Composition: Kit^W-v/Kit⁺; X/Sry^AKR/J
• Genetic Background: involves: AKR/J * C57BL/6J

endocrine/exocrine glands

decreased testis weight ( J:133266 )

♂ • Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

♂ • Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Genotype
MGI:3778792

cx102

• Allelic Composition: Kit^W-19H/Kit⁺; X/Sry^AKR/J
• Genetic Background: involves: AKR/J * C57BL/6J

reproductive system

small testis ( J:133266 )

sex reversal ( J:133266 )

• Background Sensitivity: hermaphroditism is found within two generations of backcrossing to C57BL/6 and by the third generation completely sex reversed, sterile XY females are found; the frequency of this sex reversal increases with further backcrossing to C57BL/6

endocrine/exocrine glands

small testis ( J:133266 )

Genotype
MGI:3778814

cx103

• Allelic Composition: Kit^W-e/Kit⁺; X/Sry^AKR/J
• Genetic Background: involves: AKR/J * C57BL/6J

endocrine/exocrine glands

decreased testis weight ( J:133266 )

♂ • Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

♂ • Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Genotype
MGI:3716808

cx104

• Allelic Composition: Kit^W-42J/Kit⁺; X/Sry^AKR/J
• Genetic Background: involves: AKR/J * C57BL/6J

reproductive system

small testis ( J:36829 )

♂ • males have right testis smaller than the left, especially when the alleles are inherited from the mother

true hermaphroditism ( J:36829 )

♂ • one hermaphrodite was found with a left testicular gonad and a contralateral putative ovotestis that was associated with both Mullerian and Wolffian duct derivatives

endocrine/exocrine glands

small testis ( J:36829 )

♂ • males have right testis smaller than the left, especially when the alleles are inherited from the mother

Genotype
MGI:3778815

cx105

• Allelic Composition: Kit^W-27H/Kit⁺; X/Sry^AKR/J
• Genetic Background: involves: AKR/J * C57BL/6J * CBA/H

endocrine/exocrine glands

decreased testis weight ( J:133266 )

♂ • Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

reproductive system

decreased testis weight ( J:133266 )

♂ • Background Sensitivity: in the presence of Sry^AKR/J on a C57BL/6 background testes weight is less than normal

Genotype
MGI:5297719

cx106

• Allelic Composition: Kit^W-v/Kit⁺; Tg(Mt1-RET)304Ina/0
• Genetic Background: involves: BALB/c * C57BL/6

mortality/aging

decreased tumor-free survival time ( J:88074 )

• average lifespan of mutants with tumors is 13.2 +/- 4.8 months

• 9.8% and 40.9% of mutants die of growing melanoma within 12 and 18 months of birth, respectively

neoplasm

increased melanoma incidence ( J:88074 )

• 68.9% of mutants develop melanocytic tumors

• mutants are on average tumor free until 11.9 months of age

decreased tumor incidence ( J:88074 )

• mutants exhibit suppression of melanoma development compared to single Tg(Mt1-RET)304Ina/0 mice, showing reduced tumor growth and prolonged survival

• 31.1% of mutants do not develop tumors throughout their lifetime

Genotype
MGI:6260000

cx107

• Allelic Composition: Kit^W-v/Kit⁺; Rps19^Mhdadsk3/Rps19⁺
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

pigmentation

belly spot ( J:139244 )

• adult mice show a larger white belly spot than mice that are only heterozygous for the Kit^W-v allele

integument

belly spot ( J:139244 )

• adult mice show a larger white belly spot than mice that are only heterozygous for the Kit^W-v allele

Genotype
MGI:3817635

cx108

• Allelic Composition: Kit^W/Kit⁺; Tg(PGK1-KITLG*220)441Daw/0
• Genetic Background: involves: C3H/HeJ

pigmentation

abnormal coat/hair pigmentation ( J:32600 )

• 46% of mice show coat color similar to hemizygous transgenics or heterozygous Kit^W animals, while 29% show wild-type agouti coat coloring

• 25% of double mutants have a more severe deficiency in coat color pigmentation with large areas of hypopigmentation

hypopigmentation ( J:32600 )

hematopoietic system

decreased mast cell number ( J:32600 )

• numbers of connective tissue mast cells are greatly reduced relative to controls

immune system

decreased mast cell number ( J:32600 )

• numbers of connective tissue mast cells are greatly reduced relative to controls

integument

abnormal coat/hair pigmentation ( J:32600 )

• 46% of mice show coat color similar to hemizygous transgenics or heterozygous Kit^W animals, while 29% show wild-type agouti coat coloring

• 25% of double mutants have a more severe deficiency in coat color pigmentation with large areas of hypopigmentation

Genotype
MGI:4431077

cx109

• Allelic Composition: Kit^W-v/Kit⁺; Ph/Ph⁺
• Genetic Background: involves: C57BL

pigmentation

abnormal coat/hair pigmentation ( J:125080 )

• coat color is white except for some lightly diluted fur on the snout and sides of the head

irregular coat pigmentation ( J:125080 )

integument

abnormal coat/hair pigmentation ( J:125080 )

• coat color is white except for some lightly diluted fur on the snout and sides of the head

irregular coat pigmentation ( J:125080 )

Genotype
MGI:3619906

cx110

• Allelic Composition: Fbn1^Tsk/Fbn1⁺; Kit^W/Kit⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ

pigmentation

diluted coat color ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

variable body spotting ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

integument

diluted coat color ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

variable body spotting ( J:24076 )

• variable amounts of white-spotting on a slightly diluted coat color

tight skin ( J:24076 )

skin fibrosis ( J:24076 )

• progressive development of skin fibrosis similar to that seen in single heterozygous Fbn1 mutant mice

Genotype
MGI:3716810

cx111

• Allelic Composition: Kit^W-42J/Kit⁺; X/Sry^POS-TIR
• Genetic Background: involves: C57BL/6J

reproductive system

true hermaphroditism ( J:36829 )

• 2 were identified

sex reversal ( J:36829 )

• all XY mice are female

Genotype
MGI:3813609

cx112

• Allelic Composition: a/a; Kit^W-2J/Kit⁺
• Genetic Background: involves: C57BL/6J

pigmentation

white spotting ( J:192797 )

• about 75% of the coat is pigmented on this background

integument

white spotting ( J:192797 )

• about 75% of the coat is pigmented on this background

Genotype
MGI:5523974

cx113

• Allelic Composition: Kit^Wps/Kit⁺; Pax3^Sp-1Wli/Pax3⁺
• Genetic Background: involves: C57BL/6J * CBA/CaJ

pigmentation

white spotting ( J:196572 )

• extensive white spotting than in mice heterozygous for either allele with pigment loss throughout the belly and much of the back and occasionally the head

belly spot ( J:196572 )

integument

white spotting ( J:196572 )

• extensive white spotting than in mice heterozygous for either allele with pigment loss throughout the belly and much of the back and occasionally the head

belly spot ( J:196572 )