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Spontaneous Allele Detail
Symbol: KitW-v
Name: KIT proto-oncogene receptor tyrosine kinase; viable dominant spotting
MGI ID: MGI:1856266
Synonyms: KitWv, W', W2, Wv, Wv
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: KitW-v page
KitW-v/Kit+ mouse

Show the 4 phenotype image(s) involving this allele.

Strain of Origin:  silvered black strain
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsA C-to-T point mutation at coding nucleotide 1979 (transcript NM_021099) results in a threonine to methionine substitution at amino acid 660 (p.T660M). (J:10528, J:24351)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 120 assay results
5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 27 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying KitW-v
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 10 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  179 strains or lines available
Original:  J:2447 Little CC, et al., The occurrence of a dominant spotting mutation in the house mouse. Proc Natl Acad Sci U S A. 1937 Oct;23(10):535-537
All:  451 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory