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Spontaneous Allele Detail
Symbol: a
Name: nonagouti
MGI ID: MGI:1855937
Gene: a  Location: Chr2:154792519-154892932 bp, + strand  Genetic Position: Chr2, 76.83 cM
Alliance: a page
Strain of Origin:  old mutant of the mouse fancy
Allele Type:    Spontaneous
Mutation:    Viral insertion
Mutation detailsCharacterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats (beta4 retroviral sequence). The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. (J:16984, J:24934, J:278039)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 50 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying a
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 229 strains available      Cell Lines: 0 lines available
Carrying any a Mutation:  459 strains or lines available
Insertion of the LV30 retrotransposon without the beta4 retrovirus sequence does not cause the nonagouti phenotype. J:278039
Original:  J:12970 Markert CL, et al., The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics. 1956 May;41(3):429-50
All:  104 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory