Kit^W-n
Spontaneous Allele Detail

Summary

• Symbol: Kit^W-n
• Name: KIT proto-oncogene receptor tyrosine kinase; Nagoya dominant spotting
• MGI ID: MGI:1856512
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-n page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Analysis of cDNA showed this allele comprises a C-to-T transition at nucleotide 2504 (transcript NM_021099) in the tyrosine kinase domain, resulting in a change of alanine to valine at position 835 (p.A835V). Encoded c-kit protein is not expressed on the cell surface. (J:27513)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 179 strains or lines available

References

• Original: J:12107 Go S, et al., Effect of W and W^v alleles on production of tissue mast cells in mice. J Hered. 1980;71(1):41-44
• All: 2 reference(s)