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Phenotype Image Detail
Image
Caption Cecal gastrointestinal stromal tumor (GIST) and pronounced gastric and colonic interstatial cell of Cajal (ICC) hyperplasia in Kittm4.1Bsm/Kit+ (V558delta;T669I/+) mice. Cross-sections of stomach (A-C; higher magnification is shown in A*-C*), cecum (D-F), and colon (G-I) of 3- to 4-month-old wild-type (+/+), Kittm5.1Bsm/Kit+ (V558delta/+), and Kittm4.1Bsm/Kit+ (V558delta;T669I/+) mice. Arrows indicate normal thin layer of myenteric ICC in wild-type samples. ICC hyperplasia in stomach and colon samples is indicated by black bars. Note the extensive hyperplasia involving the circular muscle layer (dotted lines) in the stomach of Kittm4.1Bsm/Kit+ mice. Photographs show representative H&E staining; n >= 3 each. (Scale bars: 50 um in A*-C*; 100 um in A-I.)
Copyright This image is from Bosbach B, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):E2276-83. Copyright 2012 National Academy of Sciences, U.S.A. J:188434
Associated
Alleles
Symbol Name
Kittm4.1Bsm KIT proto-oncogene receptor tyrosine kinase; targeted mutation 4.1, Peter Besmer
Kittm5.1Bsm KIT proto-oncogene receptor tyrosine kinase; targeted mutation 5.1, Peter Besmer
Associated
Genotypes
Allelic Composition Genetic Background
Kittm4.1Bsm/Kit+ involves: 129S1/Sv * C57BL/6J * FVB/N
Kittm5.1Bsm/Kit+ involves: 129S1/Sv * C57BL/6J * FVB/N
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory