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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Igh-J
immunoglobulin heavy chain, joining region
MGI:96461
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
involves: C57BL/6 * NZB 		abnormal immature B cell morphology J:94297
Blnktm1Dkit/Blnktm1Dkit
Igh-Jtm1(3H9-VDJ)Mwg/Igh-J+
Igk-Jtm1Mwg/Igk-J+
involves: C57BL/6 * NZB 		abnormal immature B cell morphology J:94297
Cd4tm1Mak/Cd4tm1Mak
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
B6.Cg-Cd4tm1Mak Igh-Jtm2(3H9-VDJ*)Mwg 		increased anti-double stranded DNA antibody level J:142389
Faslpr/Faslpr
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
MRL.Cg-Faslpr Igh-Jtm2(3H9-VDJ*)Mwg 		abnormal B cell receptor editing J:131138
abnormal marginal zone B cell morphology J:131138
increased anti-double stranded DNA antibody level J:131138
Foxo1tm1.1Rdp/Foxo1+
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv 		increased B cell number J:157297
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv 		absent marginal zone B cells J:157297
increased B cell number J:157297
Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sortm4(Ikbkb)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * C57BL/6 		increased B cell number J:157297
Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * C57BL/6 		decreased mature B cell number J:157297
Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd * C57BL/6 		decreased mature B cell number J:157297
Igh-Jtm1(Ighel)Cys/Igh-Jtm1(Ighel)Cys
Myd88tm1Aki/Myd88tm1Aki
Igkj1tm1(IgkHyHEL10)Mnz/0
involves: 129P2/OlaHsd 		increased IgM level J:115059
Igh-Jtm1.1Lave/Igh-Jtm1.1Lave
Igk-Jtm1.1Lave/Igk-Jtm1.1Lave
Not Specified 		abnormal B cell clonal deletion J:179317
abnormal B cell differentiation J:205708
abnormal B cell physiology J:205708
abnormal immunoglobulin level J:179317
arrested B cell differentiation J:179317, J:205708
decreased B cell number J:179317, J:205708
decreased immature B cell number J:205708
decreased mature B cell number J:205708
Igh-Jtm1.1Lave/Igh-Jtm1.1Lave
Igk-Jtm1.1Lave/Igk-Jtm1.1Lave
Tg(BCL2)22Wehi/0
involves: C57BL/6JWehi * SJL/JWehi 		abnormal B cell differentiation J:179317
Igh-Jtm1Aigl/Igh-J+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal B cell morphology J:111543
decreased B cell number J:111543
decreased B-1 B cell number J:111543
increased susceptibility to experimental autoimmune encephalomyelitis J:111543
Igh-Jtm1Aigl/Igh-J+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased susceptibility to experimental autoimmune encephalomyelitis J:111543
Igh-Jtm1Aigl/Igh-J+
Mogtm1Dpd/Mogtm1Dpd
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal nervous system morphology J:151335
abnormal optic nerve morphology J:151335
abnormal spinal cord morphology J:151335
CNS inflammation J:151335
demyelination J:151335
increased susceptibility to experimental autoimmune encephalomyelitis J:151335
muscle hypertonia J:151335
paralysis J:151335
Igh-Jtm1Aigl/Igh-J+
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal nervous system morphology J:151335
abnormal optic nerve morphology J:151335
abnormal spinal cord morphology J:151335
CNS inflammation J:151335
demyelination J:151335
increased susceptibility to experimental autoimmune encephalomyelitis J:151335
muscle hypertonia J:151335
paralysis J:151335
Igh-Jtm1Aigl/Igh-Jtm1Aigl
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N * SJL/J 		increased autoantibody level J:149511
increased susceptibility to experimental autoimmune encephalomyelitis J:149511
Igh-Jtm1Bds/Igh-J+
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:71617
Igh-Jtm1Bds/Igh-Jtm1Bds
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:99052
Igh-Jtm1Cgn/Ightm1Leck
involves: 129P2/OlaHsd * C57BL/6 		abnormal immunoglobulin light chain V-J recombination J:144033
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
involves: 129P2/OlaHsd 		decreased mature B cell number J:157297
Igh-Jtm1Cgn/Ightm4Cgn
Tg(Cr2-cre)3Cgn/0
Not Specified 		decreased B cell number J:79299
decreased follicular B cell number J:79299
decreased marginal zone B cell number J:79299
Igh-Jtm1Cgn/Ightm11.1Cgn
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:113434
Igh-Jtm1Dhu/Igh-J+
Il2tm1Hor/Il2tm1Hor
involves: 129/Sv * C57BL/6 		abnormal intestinal epithelium morphology J:29999
abnormal intestinal goblet cell morphology J:29999
anemia J:29999
cachexia J:29999
colitis J:29999
diarrhea J:29999
enlarged mesenteric lymph nodes J:29999
hunched posture J:29999
rectal hemorrhage J:29999
rectal prolapse J:29999
Igh-Jtm1Dhu/Igh-Jtm1(VDJ-17.2.25)Wabl
Igktm1Dhu/Igktm1Dhu
Not Specified 		abnormal B cell differentiation J:33628
abnormal immature B cell morphology J:89757
Igh-Jtm1Dhu/Igh-Jtm1Dhu
Il2tm1Hor/Il2tm1Hor
involves: 129/Sv * C57BL/6 		abnormal blood cell morphology/development J:29999
abnormal intestinal epithelium morphology J:29999
abnormal intestinal goblet cell morphology J:29999
cachexia J:29999
colitis J:29999
diarrhea J:29999
enlarged mesenteric lymph nodes J:29999
hunched posture J:29999
rectal hemorrhage J:29999
rectal prolapse J:29999
Igh-Jtm1Dhu/Igh-Jtm1Dhu
Wdr1rede/Wdr1rede
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 		abnormal immune system physiology J:134092
thrombocytopenia J:134092
Igh-Jtm1Dhu/Ightm1Tim
involves: 129X1/SvJ * C57BL/6 		abnormal B cell differentiation J:88410
abnormal B cell morphology J:87624
abnormal immune system organ morphology J:87624
abnormal spleen marginal zone morphology J:87624
abnormal spleen morphology J:87624
Igh-Jtm1Dhu/Ightm2Tim
involves: 129X1/SvJ * C57BL/6 		abnormal lymph node morphology J:87624
abnormal spleen morphology J:87624
decreased marginal zone B cell number J:87624
Igh-Jtm1Dhu/Ightm3Tim
involves: 129 * C57BL/6 		abnormal B cell differentiation J:102308
decreased B cell number J:102308
Igh-Jtm1Dim/Igh-J+
Igk-Jtm1Dim/Igk-J+
involves: 129S4/SvJae * C57BL/6 		abnormal B cell differentiation J:107241
increased IgG level J:107241
increased IgM level J:107241
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
involves: 129P2/OlaHsd 		absent B cells J:23827
absent mature B cells J:70620, J:137738
arrested B cell differentiation J:23827, J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:137738
abnormal immunoglobulin level J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0
involves: 129P2/OlaHsd 		abnormal B cell morphology J:23827
abnormal immunoglobulin level J:23827
increased mature B cell number J:23827
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2BM)7Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd 		abnormal immunoglobulin level J:139792
decreased B cell number J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2CM)2Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd 		abnormal immunoglobulin level J:139792
decreased B cell number J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG1/2)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd 		abnormal immunoglobulin level J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yHG4)1Amgn/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd 		abnormal immunoglobulin level J:139792
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/0
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell morphology J:70620
abnormal immunoglobulin heavy chain V(D)J recombination J:70620
abnormal immunoglobulin level J:70620
abnormal immunoglobulin light chain V-J recombination J:70620
increased mature B cell number J:70620
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Igkctm1Jkbv/Igkctm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
Tg(IGK@yK2)J23.1Jkbv/Tg(IGK@yK2)J23.1Jkbv
involves: 129P2/OlaHsd 		abnormal immunoglobulin level J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
normal immune system phenotype J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH2)J9.2Jkbv/0
involves: 129P2/OlaHsd 		abnormal immunoglobulin level J:137738
decreased mature B cell number J:137738
normal immune system phenotype J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@*)SALed/0
involves: 129P2/OlaHsd 		decreased mature B cell number J:137738
normal immune system phenotype J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:137738
abnormal immunoglobulin level J:137738
decreased immature B cell number J:137738
decreased mature B cell number J:137738
decreased pre-B cell number J:137738
increased late pro-B cell number J:137738
Igh-Jtm1Jkbv/Igh-Jtm1Jkbv
Tg(IGH@yH1)2BJkbv/0
Tg(IGK@yK1)9.2CJkbv/0
involves: 129P2/OlaHsd 		abnormal B cell morphology J:23827
abnormal immunoglobulin level J:23827
increased late pro-B cell number J:23827
increased mature B cell number J:23827
Igh-Jtm1Khyk/Igh-J+
CB17.129X1-Igh-Jtm1Khyk 		normal hematopoietic system phenotype J:109979
increased B-1 B cell number J:109979
Igh-Jtm1Mcdl/Igh-Jtm1Mcdl
Igk-Jtm1Mcdl/Igk-Jtm1Mcdl
Rag1tm1Mom/Rag1tm1Mom
Tg(DO11.10)10Dlo/?
involves: 129S/Sv * BALB/c * C3H * C57BL/6 		abnormal spleen germinal center morphology J:100072
abnormal T cell differentiation J:100072
increased IgE level J:100072
increased IgG level J:100072
Igh-Jtm2.1(4E10)Lave/Igh-Jtm2.1(4E10)Lave
Igk-Jtm2.1(4E10)Lave/Igk-Jtm2.1(4E10)Lave
involves: C57BL/6 		abnormal B cell differentiation J:205708
abnormal B cell physiology J:205708
arrested B cell differentiation J:205708
decreased immature B cell number J:205708
decreased mature B cell number J:205708
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
B6.129P2-Tcrbtm1Mom Igh-Jtm2(3H9-VDJ*)Mwg Tcrdtm1Mom 		increased anti-double stranded DNA antibody level J:142389
increased marginal zone B cell number J:142389
spleen hypoplasia J:142389
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory