Igh-J^tm1Bds
Targeted Allele Detail

Summary

• Symbol: Igh-J^tm1Bds
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, B David Stollar
• MGI ID: MGI:3581661
• Synonyms: IgM^a
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71617
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A targeting construct was designed to insert a rearranged H chain of a physiologically selected ssDNA-binding antibody into the locus. The DQ52 and JH elements were deleted upon recombination. Flow cytometry demonstrated that 67% of heterozygous mice expressed only the mutant allele, and up to 31% expressed the endogenous allele exclusively. (J:71617)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 12 strains or lines available

References

• Original: J:71617 Li J, et al., The rearranged v(h) domain of a physiologically selected anti-single-stranded dna antibody as a precursor for formation of igm and igg antibodies to diverse antigens. J Immunol. 2001 Oct 1;167(7):3746-55
• All: 2 reference(s)