Phenotypes associated with this allele

• Allele Symbol: Igh-J^tm1Bds
• Allele Name: targeted mutation 1, B David Stollar
• Allele ID: MGI:3581661
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-J^tm1Bds/Igh-J^tm1Bds	involves: 129S4/SvJae * C57BL/6	MGI:3582612
ht2	Igh-J^tm1Bds/Igh-J^+	involves: 129S4/SvJae * C57BL/6	MGI:3582611

Genotype
MGI:3582612

hm1

• Allelic Composition: Igh-J^tm1Bds/Igh-J^tm1Bds
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:99052 )

• lived in good health up to 20 months

• no abnormalities were observed in spleen, thymus or brain

• developed normal numbers of spleen and bone marrow B cells and normal serum Ig concentrations

• only the transgene allotype was expressed on splenic and bone marrow B cells

• transgene allotype expressing B cells progress through development and were precursors for cells producing IgM and IgG with extensive VH gene revision in diversification of antibody responses

Genotype
MGI:3582611

ht2

• Allelic Composition: Igh-J^tm1Bds/Igh-J⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:71617 )

• the transgene allotype was expressed on B cell surfaces and in serum Ig

• about one-third of B cells expressed the endogenous allele

• total serum Ig concentrations were normal

• transgene allotype expressing B cells served as precursors for cells producing IgM and IgG antibodies to diverse antigens