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Igh-Jtm2.1(4E10)Lave
Targeted Allele Detail
Summary
Symbol: Igh-Jtm2.1(4E10)Lave
Name: immunoglobulin heavy chain, joining region; targeted mutation 2.1, Laurent Verkoczy
MGI ID: MGI:5550246
Synonyms: 4E10 VH+
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205708
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe J1-4 regions were replaced with a J558 H10 family promoter, the H10 split leader sequence, a rearranged human heavy chain sequence of the HIV-1 antibody 4E10 (a self-/polyreactive, anti-gp41 BnAb) and a floxed neomycin resistance (neo) cassette. Cre-mediated recombination removed the neo cassette. (J:205708)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  13 strains or lines available
References
Original:  J:205708 Chen Y, et al., Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. J Immunol. 2013 Aug 1;191(3):1260-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory