Analysis Tools|
Allele Symbol Allele Name Allele ID |
Igh-Jtm2.1(4E10)Lave targeted mutation 2.1, Laurent Verkoczy MGI:5550246 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• B cell development is blocked at the small pre-B to immature B transition
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• B cell development is blocked at the small pre-B to immature B transition
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• modest blockage at the pro/large pre-B to small pre-B transition
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• B cell development is blocked at the small pre-B to immature B transition
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• B cells exhibit elevated basal activation and muted response to BCR ligation
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• modest blockage at the pro/large pre-B to small pre-B transition
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• B cell development is blocked at the small pre-B to immature B transition
|
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• B cells exhibit elevated basal activation and muted response to BCR ligation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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