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Cdkn2a
Gene Detail
Symbol

Name
ID
Cdkn2a
cyclin-dependent kinase inhibitor 2A
MGI:104738
Synonyms
Arf, ARF-INK4a, Ink4a/Arf, INK4a-ARF, MTS1, p16, p16INK4a, p19ARF, p19ARF, Pctr1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
42.15 cM, cytoband C3-C6
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr4:89274471-89294653 bp, - strand
From VEGA annotation of GRCm38

  20183 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDKN2A
Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2a

Human
homologs
CDKN2A, cyclin-dependent kinase inhibitor 2A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1029
neXtProt AC: NX_P42771, NX_Q8N726

Human Synonyms: ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS1, MTS-1, P14, P14ARF, P16, P16INK4, P16INK4A, P16-INK4A, P19, P19ARF, TP16

Human Chr (Location): 9p21; chr9:21967752-21995043 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CDKN2A

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : QTL(2) Targeted(20)
Genomic Mutations involving Cdkn2a (2)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants of p16INK4a or p19ARF proteins each show increased tumor susceptibility and sensitivity to carcinogens. Loss of both gives very early onset. p19ARF nulls also show thymic hyperplasia and the eye's hyaloid vascular system fails to regress.
 
Human Diseases Modeled in Mice Using Cdkn2a (1)    Mutations Annotated to Human Diseases (6)    Phenotype Images(7)
Interactions
Cdkn2a interacts with 1 marker (Mir1199)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (74 records)
Data Summary: Results (180)    Tissues (54)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 89
In situ reporter (knock in) 1
Northern blot 26
Western blot 5
RT-PCR 55
cDNA source data(38)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(11) cDNA(39) Primer pair(12) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000007706 (Evidence)
Ensembl Gene Model ENSMUSG00000044303 (Evidence)
Entrez Gene 12578 (Evidence)
UniGene 4733
DFCI TC1696503, TC1590868, TC1586847
DoTS DT.87047467, DT.91335312
PDB 1LNN, 1HN3
Consensus CDS Project CCDS18350.1, CCDS38812.1
International Mouse Phenotyping Consortium Status Cdkn2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007706 VEGA Gene Model | MGI Sequence Detail 20183 C57BL/6J ±  kb
transcript OTTMUST00000017645 VEGA | MGI Sequence Detail 895 Not Applicable 
polypeptide OTTMUSP00000008144 VEGA | MGI Sequence Detail 169 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(5) : PCR(3) RFLP(2) SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR010868 Cyclin-dependent kinase inhibitor 2A
References
(Earliest) J:16958 Potter M, et al., Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice. Cancer Res. 1994 Feb 15;54(4):969-75
(Latest) J:221894 Gonzalez-Valdes I, et al., Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence. Nat Commun. 2015;6:6473
All references(616)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-23975, MGD-MRK-27101, MGI:103111

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory