Cdkn2a
Gene Detail

Symbol Name ID

Cdkn2a cyclin-dependent kinase inhibitor 2A MGI:104738

Synonyms

Arf, ARF-INK4a, Ink4a/Arf, INK4a-ARF, MTS1, p16, p16INK4a, p19ARF, p19, Pctr1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

42.15 cM, cytoband C3-C6
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr4:89274473-89294653 bp, - strand From VEGA annotation of GRCm38   20181 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2a

Human homologs

Human Homolog		CDKN2A, cyclin-dependent kinase inhibitor 2A
NCBI Gene ID		1029
neXtProt AC		NX_P42771, NX_Q8N726
Human Synonyms		ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS1, MTS-1, P14, P14ARF, P16, P16INK4, P16INK4A, P16-INK4A, P19, P19ARF, TP16
Human Chr (Location)		9p21; chr9:21967751-21994490 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CDKN2A

Alleles and phenotypes

All alleles(20) : Targeted(18) QTL(2)
 

Null mutants of p16INK4a or p19ARF proteins each show increased tumor susceptibility and sensitivity to carcinogens. Loss of both gives very early onset. p19ARF nulls also show thymic hyperplasia and the eye's hyaloid vascular system fails to regress.

 
Human Diseases Modeled Using Mouse Cdkn2a (6)    Alleles Annotated to Human Diseases(6)    Phenotype Images(7)

Gene Ontology (GO) classifications

All GO classifications: (92 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, aging, ...
Component	cytoplasm, granular component, ...
Function	cyclin-dependent protein serine/threonine kinase inhibitor activity, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (51 records)
Data Summary: Results (180)    Tissues (54)    Images (41)
Theiler Stages: 10, 13, 15, 17, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	89
In situ reporter (knock in)	1
Northern blot	26
Western blot	5
RT-PCR	55

cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(65) Genomic(11) cDNA(39) Primer pair(12) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000007706 (Evidence)
Ensembl Gene Model	ENSMUSG00000044303 (Evidence)
Entrez Gene	12578 (Evidence)
UniGene	4733
DFCI	TC1586847, TC1590868, TC1696503
DoTS	DT.87047467, DT.91335312
PDB	1LNN, 1HN3
Consensus CDS Project	CCDS18350.1, CCDS38812.1
International Mouse Knockout Project Status	Cdkn2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007706	VEGA Gene Model | MGI Sequence Detail	20181	C57BL/6J
transcript	OTTMUST00000017644	VEGA | MGI Sequence Detail	850	Not Applicable
polypeptide	OTTMUSP00000008143	VEGA | MGI Sequence Detail	168	Not Applicable

All sequences(43) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(5) : PCR(3) RFLP(2) SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR010868	Cyclin-dependent kinase inhibitor 2A

References

(Earliest) J:16958 Potter M, et al., Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice. Cancer Res. 1994 Feb 15;54(4):969-75
(Latest) J:195192 Fragola G, et al., Cell reprogramming requires silencing of a core subset of polycomb targets. PLoS Genet. 2013 Feb;9(2):e1003292
All references(511)

Other accession IDs

MGD-MRK-23975, MGD-MRK-27101, MGI:103111