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Cdkn2a
Gene Detail
 Symbol
Name
ID
Cdkn2a
cyclin-dependent kinase inhibitor 2A
MGI:104738
Synonyms Arf, ARF-INK4a, Ink4a/Arf, INK4a-ARF, MTS1, p16, p16INK4a, p19ARF, p19ARF, Pctr1
Feature Type protein coding gene
Genetic Map
Chromosome 4
42.15 cM, cytoband C3-C6
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr4:89274471-89294653 bp, - strand
From VEGA annotation of GRCm38

  20183 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2a

Human
homologs
Human Homolog CDKN2A, cyclin-dependent kinase inhibitor 2A
NCBI Gene ID 1029
neXtProt AC  NX_P42771, NX_Q8N726
Human Synonyms  ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS1, MTS-1, P14, P14ARF, P16, P16INK4, P16INK4A, P16-INK4A, P19, P19ARF, TP16
Human Chr (Location)  9p21; chr9:21967752-21994491 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human CDKN2A
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : QTL(2) Targeted(19)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants of p16INK4a or p19ARF proteins each show increased tumor susceptibility and sensitivity to carcinogens. Loss of both gives very early onset. p19ARF nulls also show thymic hyperplasia and the eye's hyaloid vascular system fails to regress.
 
Human Diseases Modeled Using Mouse Cdkn2a (7)    Alleles Annotated to Human Diseases(6)    Phenotype Images(7)
Interactions
Cdkn2a interacts with 1 marker (Mir1199)
Gene Ontology
(GO)
classifications
All GO classifications: (97 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, aging, ...
Component cytoplasm, granular component, ...
Function cyclin-dependent protein serine/threonine kinase inhibitor activity, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (180)    Tissues (54)    Images (41)
Theiler Stages: 10, 13, 15, 17, 18, 19, 20, 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 89
In situ reporter (knock in) 1
Northern blot 26
Western blot 5
RT-PCR 55
cDNA source data(38)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(11) cDNA(39) Primer pair(12) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007706 (Evidence)
Ensembl Gene ModelENSMUSG00000044303 (Evidence)
Entrez Gene12578 (Evidence)
UniGene4733
DFCITC1586847, TC1590868, TC1696503
DoTSDT.87047467, DT.91335312
PDB1LNN, 1HN3
Consensus CDS ProjectCCDS18350.1, CCDS38812.1
International Mouse Knockout Project StatusCdkn2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007706 VEGA Gene Model | MGI Sequence Detail 20183 C57BL/6J ±  kb
transcript OTTMUST00000017645 VEGA | MGI Sequence Detail 895 Not Applicable 
polypeptide OTTMUSP00000008144 VEGA | MGI Sequence Detail 169 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(5) : PCR(3) RFLP(2) SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR010868 Cyclin-dependent kinase inhibitor 2A
References (Earliest) J:16958 Potter M, et al., Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice. Cancer Res. 1994 Feb 15;54(4):969-75
(Latest) J:211558 Schuster K, et al., Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis. Mol Cancer Res. 2014 Jun;12(6):912-23
All references(582)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-23975, MGD-MRK-27101, MGI:103111

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory