acute myeloid leukemia Disease Ontology Browser

Disease Ontology Browser

acute myeloid leukemia (DOID:9119)
Alliance: disease page
Synonyms: acute myeloblastic leukaemia; acute myeloblastic leukemia; acute myelogenous leukaemia; acute myelogenous leukemia; acute myeloid leukaemia; AML - acute Myeloid Leukemia; Leukemia, Myelocytic, acute
Alt IDs: OMIM:601626, DOID:9118, DOID:9171, ICD10CM:C92.0, ICD9CM:205.0, KEGG:05221, MESH:D015470, NCI:C3171, UMLS_CUI:C0023467
Definition: A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.

Term Browser
Genes (28)
Models (23)

Disease References using Mouse Models (31)

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Cebpa

Allelic Composition	Genetic Background	Reference	Phenotypes
Cebpatm8.1Nerl/Cebpatm8.1Nerl	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	J:136134	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Flt3

Allelic Composition	Genetic Background	Reference	Phenotypes
Flt3tm2.1Dosm/Flt3+	B6.129(C)-Flt3^tm2.1Dosm	J:205200	View
Flt3tm1.1Dosm/Flt3+	B6.129(C)-Flt3^tm1.1Dosm	J:205200	View
Flt3tm1Dgg/Flt3+ Kmt2atm1Clgr/Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View
Flt3tm1Dgg/Flt3tm1Dgg Kmt2atm1Clgr/Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Arid4a

Allelic Composition	Genetic Background	Reference	Phenotypes
Arid4atm1Alb/Arid4atm1Alb	involves: 129S7/SvEvBrd	J:141004	View
Arid4atm1Alb/Arid4atm1Alb Arid4btm1Alb/Arid4b+	involves: 129S7/SvEvBrd	J:141004	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Asxl1

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Crebbp

Allelic Composition	Genetic Background	Reference	Phenotypes
Crebbptm1Dli/Crebbp+	involves: 129S6/SvEvTac * C57BL/6	J:60630	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Kmt2a

Allelic Composition	Genetic Background	Reference	Phenotypes
Flt3tm1Dgg/Flt3+ Kmt2atm1Clgr/Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View
Kmt2atm2(MLLT3)Thr/Kmt2a+	involves: 129P2/OlaHsd	J:56340	View
Flt3tm1Dgg/Flt3tm1Dgg Kmt2atm1Clgr/Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View
Kmt2atm1Saam/Kmt2a+ Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * C57BL/6 * CBA	J:140628	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Mybl2

Allelic Composition	Genetic Background	Reference	Phenotypes
Mybl2tm1.1Jof/Mybl2+ Tg(Zp3-cre)3Mrt/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	J:196804	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Spi1

Allelic Composition	Genetic Background	Reference	Phenotypes
Spi1tm1.3Dgt/Spi1tm1.3Dgt	involves: 129 * BALB/c * C57BL/6	J:90331	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * CBA	J:87429	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
Npm1tm1Hft/Npm1+	involves: 129	J:194999	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

Allelic Composition	Genetic Background	Reference	Phenotypes
Ctsgtm2.1(PML/RARA)Ley/Ctsg+	involves: 129X1/SvJ * C57BL/6	J:84230, J:86458	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

Allelic Composition	Genetic Background	Reference	Phenotypes
Nr4a1tm1Jmi/Nr4a1tm1Jmi Nr4a3tm1Omc/Nr4a3tm1Omc	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	J:121903	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Transgene: Tg(CMV-SALL4_iB)#Chai

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(CMV-SALL4_iB)#Chai/?	Not Specified	J:115037	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Transgene: Tg(Vav1-Asxl1*Y588X)#Fcy

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Transgene: Tg(Vav1-ERG)#Jpim

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Vav1-ERG)#Jpim/0	involves: C57BL/6	J:203438	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/27/2021 MGI 6.17