acute myeloid leukemia Disease Ontology Browser

Disease Ontology Browser

acute myeloid leukemia (DOID:9119)
Alliance: disease page
Synonyms: acute myeloblastic leukaemia; acute myeloblastic leukemia; acute myelogenous leukaemia; acute myelogenous leukemia; acute myeloid leukaemia; AML - acute Myeloid Leukemia; Leukemia, Myelocytic, acute
Alt IDs: OMIM:601626, DOID:9118, DOID:9171, ICD10CM:C92.0, ICD9CM:205.0, KEGG:05221, MESH:D015470, NCI:C3171, UMLS_CUI:C0023467
Definition: A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.

Term Browser
Genes (102)
Models (23)

Disease References using Mouse Models (33)

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Asxl1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Cebpa

Allelic Composition	Genetic Background	Reference	Phenotypes
\Cebpatm8.1Nerl/\Cebpatm8.1Nerl	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	J:136134	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Crebbp

Allelic Composition	Genetic Background	Reference	Phenotypes
\Crebbptm1Dli/\Crebbp+	involves: 129S6/SvEvTac * C57BL/6	J:60630	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Flt3

Allelic Composition	Genetic Background	Reference	Phenotypes
\Flt3tm2.1Dosm/\Flt3+	B6.129(C)-Flt3^tm2.1Dosm	J:205200	View
\Flt3tm1.1Dosm/\Flt3+	B6.129(C)-Flt3^tm1.1Dosm	J:205200	View
\Flt3tm1Dgg/\Flt3+ \Kmt2atm1Clgr/\Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View
\Flt3tm1Dgg/\Flt3tm1Dgg \Kmt2atm1Clgr/\Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Kmt2a

Allelic Composition	Genetic Background	Reference	Phenotypes
\Flt3tm1Dgg/\Flt3+ \Kmt2atm1Clgr/\Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View
\Kmt2atm2(MLLT3)Thr/\Kmt2a+	involves: 129P2/OlaHsd	J:56340	View
\Flt3tm1Dgg/\Flt3tm1Dgg \Kmt2atm1Clgr/\Kmt2a+	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J	J:189096	View
\Kmt2atm1Saam/\Kmt2a+ \Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * C57BL/6 * CBA	J:140628	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Arid4a

Allelic Composition	Genetic Background	Reference	Phenotypes
\Arid4atm1Alb/\Arid4atm1Alb	involves: 129S7/SvEvBrd	J:141004	View
\Arid4atm1Alb/\Arid4atm1Alb \Arid4btm1Alb/\Arid4b+	involves: 129S7/SvEvBrd	J:141004	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Mybl2

Allelic Composition	Genetic Background	Reference	Phenotypes
\Mybl2tm1.1Jof/\Mybl2+ \Tg(Zp3-cre)3Mrt/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	J:196804	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Gene: Spi1

Allelic Composition	Genetic Background	Reference	Phenotypes
\Spi1tm1.3Dgt/\Spi1tm1.3Dgt	involves: 129 * BALB/c * C57BL/6	J:90331	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
\Krastm4Tyj/\Kras+ \Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * CBA	J:87429	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

NOT Models
No similarity to the expected human disease phenotype was found.

Allelic Composition	Genetic Background	Reference	Phenotypes
\Npm1tm1Hft/\Npm1+	involves: 129	J:194999	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Transgene: Tg(CMV-SALL4_iB)#Chai

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(CMV-SALL4_iB)#Chai/?	Not Specified	J:115037	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Transgene: Tg(Vav1-Asxl1*Y588X)#Fcy

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Vav1-Asxl1*Y588X)#Fcy/0	C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy	J:257690	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia
Associated Mouse Transgene: Tg(Vav1-ERG)#Jpim

Allelic Composition	Genetic Background	Reference	Phenotypes
\Tg(Vav1-ERG)#Jpim/0	involves: C57BL/6	J:203438	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

Allelic Composition	Genetic Background	Reference	Phenotypes
\Ctsgtm2.1(PML/RARA)Ley/\Ctsg+	involves: 129X1/SvJ * C57BL/6	J:84230, J:86458	View

Mouse Models

Human Disease Modeled: acute myeloid leukemia

Allelic Composition	Genetic Background	Reference	Phenotypes
\Nr4a1tm1Jmi/\Nr4a1tm1Jmi \Nr4a3tm1Omc/\Nr4a3tm1Omc	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	J:121903	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24