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Arid4a Gene Detail
Summary
  • Symbol
    Arid4a
  • Name
    AT-rich interaction domain 4A
  • Synonyms
    A630067N03Rik, Rbbp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444354
    NCBI Gene: 238247
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:71062764-71145366 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 29.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1943 from dbSNP Build 142
  • Strain Annotations
    23
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444354
 protein coding gene Chr12:71061314-71146125 (+)
129S1/SvImJ ENSMUSGG00200054815
 protein coding gene Chr12:62985780-63016508 (+)
A/J ENSMUSGG00195055223
 protein coding gene Chr12:65674276-65704930 (+)
A/J ENSMUSG00195012716
 protein coding gene Chr12:65717654-65732964 (+)
AKR/J ENSMUSGG00220054834
 protein coding gene Chr12:63482578-63513216 (+)
AKR/J ENSMUSG00220014193
 protein coding gene Chr12:63525943-63541264 (+)
BALB/cJ ENSMUSGG00180055305
 protein coding gene Chr12:64673338-64703990 (+)
BALB/cJ ENSMUSG00180030329
 protein coding gene Chr12:64716714-64732023 (+)
C3H/HeJ ENSMUSGG00175054802
 protein coding gene Chr12:67767657-67798305 (+)
C3H/HeJ ENSMUSG00175026403
 protein coding gene Chr12:67811028-67826337 (+)
C57BL/6NJ ENSMUSGG00215055651
 protein coding gene Chr12:64053900-64084537 (+)
C57BL/6NJ ENSMUSG00215028050
 protein coding gene Chr12:64097262-64112612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017824
 protein coding gene Chr12:65657532-65724882 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210028615
 protein coding gene Chr12:64281021-64296327 (+)
CBA/J ENSMUSGG00210054535
 protein coding gene Chr12:64237649-64268298 (+)
DBA/2J ENSMUSGG00185057474
 protein coding gene Chr12:66136983-66167627 (+)
DBA/2J ENSMUSG00185004455
 protein coding gene Chr12:66180350-66195660 (+)
FVB/NJ ENSMUSGG00205054340
 protein coding gene Chr12:63878211-63909174 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230018468
 protein coding gene Chr12:73153440-73168783 (+)
LP/J ENSMUSGG00230055429
 protein coding gene Chr12:73110083-73140716 (+)
NOD/ShiLtJ ENSMUSGG00190054762
 protein coding gene Chr12:63299414-63330049 (+)
NOD/ShiLtJ ENSMUSG00190011367
 protein coding gene Chr12:63342773-63358120 (+)
NZO/HlLtJ ENSMUSGG00225055409
 protein coding gene Chr12:75179550-75210275 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ARID4A, AT-rich interaction domain 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARID4A, AT-rich interaction domain 4A
  • Synonyms
    RBBP-1, RBBP1, RBP-1, RBP1
  • Links
    NCBI Gene ID: 5926
    UniProt: P29374

  • Chr Location
    14q23.1; chr14:58298504-58373887 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arid4a mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 4 alleles in 5 genetic backgrounds
    33 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered DNA methylation patterns, disrupted hematopoiesis and a portion develop acute myeloid leukemia. Mice homozygous for an ENU-induced allele exhibit short tibia and femur.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    695
  • Tissues
    96
  • cDNA Data
    15
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048118 Ensembl Gene Model | MGI Sequence Detail 82603 C57BL/6J ±  kb
    transcript ENSMUST00000046305 Ensembl | MGI Sequence Detail 4998 Not Applicable  
    polypeptide ENSMUSP00000035512 Ensembl | MGI Sequence Detail 1261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:17080 Girling R, et al., A new component of the transcription factor DRTF1/E2F [published erratum appears in Nature 1993 Sep 30;365(6445):468]. Nature. 1993 Mar 4;362(6415):83-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory