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Arid4a Gene Detail
Summary
  • Symbol
    Arid4a
  • Name
    AT-rich interaction domain 4A
  • Synonyms
    A630067N03Rik, Rbbp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444354
    NCBI Gene: 238247
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:71062764-71145366 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 29.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    517 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444354
protein coding gene Chr12:71061314-71146125 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019814
protein coding gene Chr12:70801375-70877579 (+)
A/J MGP_AJ_G0019772
protein coding gene Chr12:68156235-68228113 (+)
AKR/J MGP_AKRJ_G0019748
protein coding gene Chr12:70194132-70270960 (+)
BALB/cJ MGP_BALBcJ_G0019752
protein coding gene Chr12:68627558-68698104 (+)
C3H/HeJ MGP_C3HHeJ_G0019557
protein coding gene Chr12:70674555-70752937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020204
protein coding gene Chr12:73048242-73131511 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017824
protein coding gene Chr12:65657532-65724882 (+)
CAST/EiJ MGP_CASTEiJ_G0019109
protein coding gene Chr12:65416341-65491307 (+)
CBA/J MGP_CBAJ_G0019527
protein coding gene Chr12:75762013-75852678 (+)
DBA/2J MGP_DBA2J_G0019643
protein coding gene Chr12:68059582-68138501 (+)
FVB/NJ MGP_FVBNJ_G0019630
protein coding gene Chr12:66948444-67018207 (+)
LP/J MGP_LPJ_G0019715
protein coding gene Chr12:70777233-70863398 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019669
protein coding gene Chr12:79010072-79085443 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020239
protein coding gene Chr12:69696222-69764097 (+)
PWK/PhJ MGP_PWKPhJ_G0018874
protein coding gene Chr12:62337430-62412377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018669
protein coding gene Chr12:64055693-64126902 (+)
WSB/EiJ MGP_WSBEiJ_G0019160
protein coding gene Chr12:70301691-70374138 (+)



Homology
more
  • Human Ortholog
    ARID4A, AT-rich interaction domain 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARID4A, AT-rich interaction domain 4A
  • Synonyms
    RBBP1, RBBP-1, RBP1, RBP-1
  • Links
    NCBI Gene ID: 5926
    neXtProt AC: NX_P29374
    UniProt: P29374

  • Chr Location
    14q23.1; chr14:58298504-58373887 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Arid4a mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 4 alleles in 5 genetic backgrounds
    33 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered DNA methylation patterns, disrupted hematopoiesis and a portion develop acute myeloid leukemia. Mice homozygous for an ENU-induced allele exhibit short tibia and femur.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048118 Ensembl Gene Model | MGI Sequence Detail 82603 C57BL/6J ±  kb
    transcript ENSMUST00000046305 Ensembl | MGI Sequence Detail 4998 Not Applicable  
    polypeptide ENSMUSP00000035512 Ensembl | MGI Sequence Detail 1261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:320044 Zhang Y, et al., SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998 Jun;1(7):1021-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory