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Human Disease and Mouse Model Detail
Human Disease Amyotrophic Lateral Sclerosis 1; ALS1
OMIM ID: 105400
Synonyms Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis 1, Familial; FALS
View all models View ALL (48) mouse models for this human disease.
Genes and
mouse models
Mutations in human and/or mouse homologs are associated with this disease

      *Gene is associated with the disease in this species
      Mouse Homologs Human Homologs Mouse Models Mouse : Human
Homology Class
     Sod2* SOD2 View 1 model 1:1 Homology
Tardbp* TARDBP View 1 model 1:1 Homology
Vegfa* VEGFA View 1 model 1:1 Homology
Vps54* VPS54 View 1 model 1:1 Homology
     Dctn1 DCTN1*   1:1 Homology
Nefh NEFH*   1:1 Homology
Prph PRPH*   1:1 Homology
Sod1 SOD1*   1:1 Homology
Transgenes and
other genome features
Transgenes and other genome features developed in mice to model this disease.

     Transgenes and Other Genome Features Mouse Models
  Tg(Myl1-SOD1*G93A)#Amu View 1 model
  Tg(NEFH)200Jpj View 2 models
  Tg(NFH)120Jpj View 2 models
  Tg(Prnp-SOD1*G37R,-PSEN1)110Dbo View 1 model
  Tg(SOD1*)125Dbo View 1 model
  Tg(SOD1*)DF7Yaw View 2 models
  Tg(SOD1*G37R)1Dwc View 2 models
  Tg(SOD1*G37R)9Dpr View 1 model
  Tg(SOD1*G37R)29Dpr View 1 model
  Tg(SOD1*G37R)42Dpr View 1 model
  Tg(SOD1*G37R)106Dpr View 1 model
  Tg(SOD1*G85R)74Dwc View 1 model
  Tg(SOD1*G85R)148Dwc View 1 model
  Tg(SOD1*G85R)#Roos View 2 models
  Tg(Sod1*G86R)M1Jwg View 1 model
  Tg(SOD1*G93A)1Gur View 5 models
  Tg(SOD1*G93A)2Gur View 1 model
  Tg(SOD1*G93A)dl1Gur View 2 models
  Tg(SOD1*G127X)716Mrkl View 1 model
  Tg(SOD1*H46R)#Maw View 1 model
  Tg(SOD1*H46R*H48Q)58Dbo View 1 model
  Tg(SOD1*H46R*H48Q)139Dbo View 1 model
  Tg(SOD1*L126Z)#Deng View 2 models
  Tg(TARDBP)#Jpj View 1 model
  Tg(TARDBP*A315T)#Jpj View 1 model
  Tg(TARDBP*G348C)#Jpj View 1 model
  Tg(Thy1-Sncg)HvP36Putt View 1 model
  Tg(Thy1-SOD1*G93A)T3Hgrd View 2 models
  Tg(Thy1-TARDBP)4Singh View 2 models
  Tg(Thy1-TARDBP)6Singh View 1 model
References Disease References using Mouse Models (91)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory