Tg(SOD1*H46R*H48Q)139Dbo
Transgene Detail

Summary

• Symbol: Tg(SOD1*H46R*H48Q)139Dbo
• Name: transgene insertion 139, David Borschelt
• MGI ID: MGI:3695885
• Transgene: Tg(SOD1*H46R*H48Q)139Dbo Location: unknown
• Alliance: Tg(SOD1*H46R*H48Q)139Dbo page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 12kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine and the histidine at position 48 was replaced by glutamine in the encoded protein. (J:119631)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:119631 Wang J, et al., Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site. Neurobiol Dis. 2002 Jul;10(2):128-38
• All: 5 reference(s)