100 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apptm3.1Tcs/Apptm3.1Tcs Mapttm1.1(MAPT)Tcs/Mapttm1.1(MAPT)Tcs involves: 129S/SvEv * C57BL/6	amyloid beta deposits	J:278451
	CNS inflammation	J:278451
	increased neuron apoptosis	J:278451
Bdnftm1Msd/Bdnftm1Msd Mapttm1(cre)Nagy/Mapt+ involves: 129S1/Sv * 129X1/SvJ	normal mortality/aging	J:131394
	normal nervous system phenotype	J:131394
	reduced long-term potentiation	J:131394
Bdnftm1Yab/Bdnftm1Yab Mapttm1(cre)Nagy/Mapt+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal dendrite morphology	J:157932
	abnormal locomotor activation	J:157932
	abnormal neuron morphology	J:157932
	abnormal optic nerve morphology	J:157932
	decreased body weight	J:157932
	decreased brain size	J:157932
	decreased brain weight	J:157932
	decreased striatum size	J:157932
	increased anxiety-related response	J:157932
	increased body weight	J:157932
	limb grasping	J:157932
	postnatal growth retardation	J:157932
	postnatal lethality, complete penetrance	J:157932
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg Mapttm2Arbr/? H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J	abnormal axon morphology	J:226826
	abnormal craniofacial development	J:226826
	abnormal nociceptor morphology	J:226826
	abnormal sensory neuron innervation pattern	J:226826
	perinatal lethality	J:226826
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg Mapttm2Arbr/? Runx1tm1(cre/Esr1*)Ims/? involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	abnormal mechanoreceptor morphology	J:226826
Chattm2(cre)Lowl/Chat+ Mapttm2(FUS)Neas/Mapt+ B6.129-Mapttm2(FUS)Neas Chattm2(cre)Lowl	abnormal neuromuscular synapse morphology	J:232167
	motor neuron degeneration	J:232167
Chattm2(cre)Lowl/Chat+ Mapttm3(FUS)Neas/Mapt+ B6.129-Mapttm3(FUS)Neas Chattm2(cre)Lowl	abnormal neuromuscular synapse morphology	J:232167
	motor neuron degeneration	J:232167
Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi Mapttm3.1(FUS)Neas/Mapt+ Ndor1Tg(UBC-cre/ERT2)1Ejb/0 involves: 129 * C3H * C57BL/6 * C57BL/6N	abnormal neuromuscular synapse morphology	J:232167
Isl1tm1(cre)Tmj/Isl1+ Mapttm1(Ewsr1/Etv4)Arbr/Mapt+ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal dorsal root ganglion morphology	J:100886
	abnormal sensory neuron innervation pattern	J:100886
	abnormal sensory neuron morphology	J:100886
	decreased muscle spindle number	J:100886
Kansl1/Mapttm1.1Cole/Kansl1/Mapttm1.1Cole involves: C57BL/6 * C57BL/6J * C57BL/6JOlaHsd	abnormal axonal transport	J:188213
	normal behavior/neurological phenotype	J:188213
	hyperactivity	J:188213
	normal nervous system phenotype	J:188213
Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm Mapttm2Arbr/Mapt+ involves: 129P2/OlaHsd	abnormal brainstem morphology	J:121332
	abnormal medulla oblongata morphology	J:121332
	abnormal neuron differentiation	J:121332
	abnormal neuron morphology	J:121332
	abnormal neuron specification	J:121332
	increased sensory neuron number	J:121332
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/0 B6.Cg-Tg(MAPT)8cPdav Mapttm1(EGFP)Klt/J	abnormal spatial learning	J:172426
	neurofibrillary tangles	J:172426
	normal taste/olfaction phenotype	J:172426
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/? involves: 129S4/SvJae * C57BL/6 * Swiss Webster	abnormal neuron morphology	J:84638
	abnormal renal glomerulus morphology	J:174270
	abnormal spleen B cell follicle morphology	J:174270
	abnormal spleen B cell follicle shape	J:174270
	abnormal spleen red pulp morphology	J:174270
	amyloidosis	J:174270
	increased follicular lymphoma incidence	J:174270
	increased lymphoma incidence	J:174270
	increased spleen B cell follicle size	J:174270
	tau protein deposits	J:84638
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(Thy1-MAPT*)30Schd/0 involves: 129S4/SvJae * C57BL/6 * CBA	abnormal brain morphology	J:169074
	abnormal sciatic nerve morphology	J:169074
	abnormal spinal cord morphology	J:169074
	normal behavior/neurological phenotype	J:169074
	impaired coordination	J:169074
	normal nervous system phenotype	J:169074
	neurofibrillary tangles	J:169074
	premature death	J:169074
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+ Mnx1tm4(cre)Tmj/Mnx1+ involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	abnormal axon extension	J:100886
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln FVB.Cg-Mapttm1(MAPT)Vln	abnormal motor coordination/balance	J:96869
	normal nervous system phenotype	J:96869
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln involves: FVB/N	abnormal axon extension	J:129032
	abnormal dendrite morphology	J:129032
	abnormal hippocampus pyramidal cell morphology	J:129032
	decreased anxiety-related response	J:129032
	enhanced long-term object recognition memory	J:129032
	enlarged hippocampus	J:129032
	increased cell proliferation	J:129032
Mapttm1(Mecp2)Jae/Mapt+ involves: 129/Sv * C57BL/6	no abnormal phenotype detected	J:89593
Mapttm1(Mecp2)Jae/Mapt+ Mecp2tm1.1Jae/Mecp2+ involves: 129S4/SvJae * C57BL/6	normal behavior/neurological phenotype	J:89593
	normal growth/size/body region phenotype	J:89593
	normal nervous system phenotype	J:89593
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae B6.Cg-Mapttm1(Mecp2)Jae	abnormal associative learning	J:182685
	abnormal contextual conditioning behavior	J:182685
	abnormal cued conditioning behavior	J:182685
	abnormal miniature excitatory postsynaptic currents	J:182685
	abnormal object recognition memory	J:182685
	decreased body weight	J:182685
	enhanced paired-pulse facilitation	J:182685
	impaired coordination	J:182685
	increased anxiety-related response	J:182685
	reduced long-term potentiation	J:182685
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae involves: 129/Sv * C57BL/6	abnormal sexual interaction	J:89593
	ataxia	J:89593
	cachexia	J:89593
	cataract	J:89593
	disheveled coat	J:89593
	excessive scratching	J:89593
	impaired balance	J:89593
	normal mortality/aging	J:89593
	postnatal growth retardation	J:89593
	tremors	J:89593
Mapttm1(Sema3e)Yuyo/Mapt+ Olig2tm1(cre)Tmj/Olig2+ Not Specified	abnormal excitatory postsynaptic potential	J:205528
	abnormal sensory neuron innervation pattern	J:205528
	abnormal synaptic bouton morphology	J:205528
	normal nervous system phenotype	J:205528
Mapttm1(Setdb1)Akba/Mapt+ Mecp2tm1Jae/Y Tg(Nes-cre)1Atp/0 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N	impaired coordination	J:178512
	premature death	J:178512
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba Mecp2tm1Jae/Y Tg(Nes-cre)1Atp/0 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N	impaired coordination	J:178512
	premature death	J:178512
Mapttm1.1(FUS)Neas/Mapt+ B6J.129P2(129S)-Mapttm1.1(FUS)Neas	normal nervous system phenotype	J:232167
Mapttm1.1(FUS)Neas/Mapttm1.1(FUS)Neas B6J.129P2(129S)-Mapttm1.1(FUS)Neas	normal nervous system phenotype	J:232167
Mapttm1Hnd/Mapt+ Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	abnormal neuron differentiation	J:121330
	abnormal neuron morphology	J:121330
	abnormal spatial learning	J:121330
	amyloid beta deposits	J:121330
	normal behavior/neurological phenotype	J:121330
	decreased susceptibility to pharmacologically induced seizures	J:121330
Mapttm1Hnd/Mapttm1Hnd Zbtb20Tg(PDGFB-APPSwInd)20Lms/0 involves: 129X1/SvJ * C57BL/6 * DBA/2	abnormal neuron differentiation	J:121330
	abnormal neuron morphology	J:121330
	amyloid beta deposits	J:121330
	normal behavior/neurological phenotype	J:121330
	decreased susceptibility to pharmacologically induced seizures	J:121330
Mapttm2(Hdac1)Jae/Mapttm2(Hdac1)Jae involves: 129S4/SvJae * C57BL/6	abnormal hippocampus pyramidal cell morphology	J:148391
Mapttm2.1(FUS)Neas/Mapt+ B6J.129P2(129S)-Mapttm2.1(FUS)Neas	abnormal motor neuron innervation pattern	J:232167
	abnormal neuromuscular synapse morphology	J:232167
	astrocytosis	J:232167
	microgliosis	J:232167
	motor neuron degeneration	J:232167
Mapttm2.1(RHOA*)Klt/Mapt+ involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal somatosensory cortex morphology	J:159220
	decreased neuron apoptosis	J:159220
	increased neuron number	J:159220
	normal nervous system phenotype	J:159220
Mapttm2Arbr/Mapt+ Neurod6tm1(cre)Kan/Neurod6+ Trim67tm1.1Slgu/Trim67tm1.1Slgu involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	decreased corpus callosum size	J:266702
Mapttm2Arbr/Mapt+ Shox2tm1.1(cre)Oki/Shox2+ Slc17a6tm1.1Thna/Slc17a6tm1.2Edw involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	abnormal nervous system physiology	J:209344
Mapttm2Arbr/? Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj	abnormal mechanoreceptor morphology	J:226826
Mapttm2Arbr/? Runx1tm3Spe/Runx1tm3Spe H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J	abnormal axon morphology	J:226826
	abnormal sensory neuron innervation pattern	J:226826
Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae involves: 129S4/SvJae * C57BL/6	abnormal dentate gyrus morphology	J:148391
	abnormal hippocampus CA1 region morphology	J:148391
	abnormal hippocampus pyramidal cell morphology	J:148391
	abnormal spatial learning	J:148391
	abnormal spatial working memory	J:148391
	impaired contextual conditioning behavior	J:148391
	reduced long-term potentiation	J:148391
Mapttm3.1(FUS)Neas/Mapt+ B6J.129P2(129S)-Mapttm3.1(FUS)Neas	abnormal motor neuron innervation pattern	J:232167
	abnormal neuromuscular synapse morphology	J:232167
	abnormal sarcomere morphology	J:232167
	abnormal synaptic bouton morphology	J:232167
	abnormal synaptic depression	J:232167
	abnormal synaptic transmission	J:232167
	abnormal tibialis anterior morphology	J:232167
	astrocytosis	J:232167
	microgliosis	J:232167
	motor neuron degeneration	J:232167
	paraparesis	J:232167
Mapttm3.1(FUS)Neas/Mapttm3.1(FUS)Neas B6J.129P2(129S)-Mapttm3.1(FUS)Neas	abnormal neuromuscular synapse morphology	J:232167
Smc3tm1.1Toshi/Smc3+ Mapttm2(cre)Aha/Mapt+ involves: C57BL/6J	decreased CNS synapse formation	J:242006
	increased anxiety-related response	J:242006
Smc3tm1.1Toshi/Smc3tm1.1Toshi Mapttm2(cre)Aha/? involves: C57BL/6J	decreased body size	J:242006
	postnatal growth retardation	J:242006
	premature death	J:242006