Mapttm2(cre)Aha
Targeted Allele Detail
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Symbol: |
Mapttm2(cre)Aha |
Name: |
microtubule-associated protein tau; targeted mutation 2, Akihiro Harada |
MGI ID: |
MGI:3793311 |
Synonyms: |
tau-Cre |
Gene: |
Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
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Alliance: |
Mapttm2(cre)Aha page
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Germline Transmission: |
Earliest citation of germline transmission:
J:134499
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Mapttm2(cre)Aha expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Mapt (MGI:97180) |
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Mutation details: A cre gene with a nuclear localization signal followed by an frt-flanked neo cassette was inserted immediately after the start methionine. Cre function is dectected in neurons of almost all areas of the brain with only granule cells in the caudal part of the cerebellum not exhbiting cre function. Other organs such as the liver, kidney and intestine do not exhibit cre function.
(J:134499)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Mapt
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mapt Mutation: |
428 strains or lines available
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Original: |
J:134499 Muramatsu K, et al., Neuron-specific recombination by Cre recombinase inserted into the murine tau locus. Biochem Biophys Res Commun. 2008 Jun 6;370(3):419-23 |
All: |
7 reference(s) |
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