Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm2(cre)Aha mutation
(0 available);
any
Mapt mutation
(428 available)
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nervous system
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N |
• mice are viable and fertile with no reduction in brain weight compared to wild-type; mice have normal lifespans
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm2(cre)Aha mutation
(0 available);
any
Mapt mutation
(428 available)
Smc3tm1.1Toshi mutation
(0 available);
any
Smc3 mutation
(47 available)
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mortality/aging
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• mice die by 5 weeks of age
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growth/size/body
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• mice are significantly smaller than controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm2(cre)Aha mutation
(0 available);
any
Mapt mutation
(428 available)
Smc3tm1.1Toshi mutation
(0 available);
any
Smc3 mutation
(47 available)
|
|
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behavior/neurological
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• in the novelty-induced hypophagia test, adult males show a significantly longer latency to drink milk in a novel, brightly lit cage as well as reduced milk consumption relative to controls, indicating increased anxiety
• however, no significant differences are noted in the light/dark transition or marble-burying tests
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nervous system
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• at P21, Stat1 expression in the cortex is significantly higher than in controls
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Analysis Tools
