Mapt^tm1(MAPT)Vln
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1(MAPT)Vln
• Name: microtubule-associated protein tau; targeted mutation 1, Fred Van Leuven
• MGI ID: MGI:3768527
• Synonyms: tau-KOKI
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1(MAPT)Vln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96869
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Modified isoform(s), Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts replaced the endogenous mouse gene. Endogenous mouse Mapt protein is not expressed, and the inserted human gene is expressed in brain driven by a murine Thy1 promoter beginning at P15. (J:96869)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:96869 Terwel D, et al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem. 2005 Feb 4;280(5):3963-73
• All: 2 reference(s)