Mapt^{tm2.1(RHOA*)Klt}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm2.1(RHOA*)Klt}
• Name: microtubule-associated protein tau; targeted mutation 2.1, Kerry Lee Tucker
• MGI ID: MGI:4442945
• Synonyms: N19-RhoA
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm2.1(RHOA*)Klt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159220
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mapt^{tm2.1(RHOA*)Klt} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RHOA (387)

  Rhoa	(MGI:1096342)

• Mutation details: Cre mediated recombination removed the floxed STOP cassette allowing for the expression of the dominant-negative transcript. (J:159220)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:159220 Sanno H, et al., Control of postnatal apoptosis in the neocortex by RhoA-subfamily GTPases determines neuronal density. J Neurosci. 2010 Mar 24;30(12):4221-31
• All: 1 reference(s)